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Improving rotavirus vaccine coverage: Can newer-generation and locally produced vaccines help?

  • 2017/11/14
Type of publication
  • Articles
  • Deen
  • J.; Lopez
  • A.L.; Kanungo
  • S.; Wang
  • X.Y.; Anh
  • D.D.; Tapia
  • M.; Grais
  • R.F.
  • Vaccination
There are two internationally available WHO-prequalified oral rotavirus vaccines (Rotarix and RotaTeq), two rotavirus vaccines licensed in India (Rotavac and Rotasiil), one in China (Lanzhou lamb rotavirus vaccine) and one in Vietnam (Rotavin-M1), and several candidates in development. Rotavirus vaccination has been rolled out in Latin American countries and is beginning to be deployed in sub-Saharan African countries but middle- and low-income Asian countries have lagged behind in rotavirus vaccine introduction. We provide a mini-review of the leading newer-generation rotavirus vaccines and compare them with Rotarix and RotaTeq. We discuss how the development and future availability of newer-generation rotavirus vaccines that address the programmatic needs of poorer countries may help scale-up rotavirus vaccination where it is needed.