Epicentre Uganda

Monday 4 February 2019 - Updated on Monday 17 February 2020
At the heart of Mbarara University of Science and Technology (MUST) and Mbarara Regional Referral Hospital (MRRH), Epicentre has been conducting clinical research work for more than 20 years.

Research

A child participates in the yellow fever clinical trial
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A child participates in the yellow fever clinical trial.

Epicentre’s Uganda Research Centre conducts health related research aimed at influencing policy globally and relevant to Africa and Uganda in particular. Studies are conducted according to Good Clinical Practice and Good Clinical and Laboratory Practice quality standards. Epicentre collaborates closely with the Mbarara University of Science and Technology (MUST), the Mbarara Regional Referral Hospital (MRRH), the Ministry of Health and other stakeholders in research, academia and the health sector.
 
The centre has an experienced team of medical doctors, nurses, social workers, statisticians, biologists, laboratory technicians, information technology scientists, logisticians, and administrators who ensure the quality of the research. 

Epicentre research has contributed to policy changes including the seminal AQUAMAT trial that demonstrated that artesunate significantly reduces mortality in African children with severe malaria. Current projects continue to focus on improving diagnosis and therapies for tuberculosis, HIV, central nervous system infections, as well as trials on Ebola and Yellow fever vaccines. 
 

Laboratory

Epicentre laboratory in Mbabane, Uganda
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At work in the Mbarara laboratory. Epicentre has a laboratory with a biosafety level 3.

Epicentre Uganda benefits from a laboratory located within the Epicentre facility with a biosafety level 3. The laboratory is equipped to do parasitology, (with extensive experience in malaria microscopy), mycobacteriology (biosafety level 3 to perform cultures), microbiology (biosafety level 2, molecular biology; classical PCR and real-time qPCR, use of GeneXpert), biochemistry and haematology with skills to handle specimens for shipment according to IATA regulations. It also has a cold chain capacity for – 20 and – 80 degrees storage.
 

Education

Taking advantage of its position at the heart of the Mbarara campus the centre is also actively engaged in teaching at the MUST Faculty of Medicine. Research Centre staff contribute to teaching in research methods, supervision and mentorship in research to Faculty of medicine MUST students. In addition, Epicentre laboratory staff contribute modules to bachelor's and master's courses in microbiology, molecular biology, and medical laboratory sciences. Laboratory Science students have the opportunity to gain valuable experience in the Research Center’s laboratory. 
 

Introducing Epicentre Uganda

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Introducing Epicentre in Uganda - Video

Selected publications

Pharmacokinetics of efavirenz in patients on antituberculosis treatment in high human immunodeficiency virus and tuberculosis burden countries: A systematic review.

Journal Reference: British journal of clinical pharmacology 2018 Aug ; 84(8); 1641-1658. doi: 10.1111/bcp.13600. Epub 2018 05 22

Xpert(®) MTB/RIF for detection of Mycobacterium tuberculosis from frozen string and induced sputum sediments.

Journal Reference: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2016 08 ; 20(8); 1113-7. doi: 10.5588/ijtld.15.0691. Epub 2018 01 23
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Activities in Uganda

Scientific Day Uganda 2017

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Bannière Legende test portrait

Yellow fever

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Yellow Fever Vaccination campaign DRC

Tuberculosis

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Sputum sample analysis

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Archive room at the research center
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The archive room at Epicentre Uganda.
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Dr. Juliet Mwanga-Amumpaire, Director Epicentre Uganda
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Dr. Juliet Mwanga-Amumpaire, Director Epicentre Uganda.
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Isolation Unit on the campus of Mbarara University of Science and Technology (MUST)
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Isolation Unit on the campus of Mbarara University of Science and Technology (MUST).
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Test tubes in the laboratory in Mbarara
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Test tubes in the laboratory in Mbarara.
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Working in the Laboratory, Epicentre Uganda
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Working in the Laboratory, Epicentre Uganda.