Successes and gaps in the HIV cascade of care of a high HIV prevalence setting in Zimbabwe: a population-based survey.


INTRODUCTION: Gutu, a rural district in Zimbabwe, has been implementing comprehensive HIV care with the support of Médecins Sans Frontières (MSF) since 2011, decentralizing testing and treatment services to all rural healthcare facilit

Authors: Conan N Coulborn RM Simons E Mapfumo A Apollo T Garone DB Casas EC Puren AJ Chihana ML Maman D
Journal Reference: Journal of the International AIDS Society 2020 Sep ; 23(9); e25613. doi: 10.1002/jia2.25613. Epub 2020 10 01
ART HIV cascade of care incidence prevalence viral suppression

Culture Conversion in Patients Treated with Bedaquiline and/or Delamanid: A Prospective Multi-country Study.


Background Bedaquiline and delamanid offer the possibility of more effective and less toxic multidrug-resistant tuberculosis (MDR-TB) treatment. With this treatment, however, some patients, remain at high risk for an unfavorable treatment outcome.

Authors: Franke MF Khan P Hewison C Khan U Huerga H Seung KJ Rich ML Zarli K Samieva N Oyewusi L Nair P Mudassar M Melikyan N Lenggogeni P Lecca L Kumsa A Khan M Islam S Hussein K Docteur W Chumburidze N Berikova E Atshemyan H Atwood S Alam M Ahmed S Bastard M Mitnick CD
Journal Reference: American journal of respiratory and critical care medicine 2020 Jul 24; (); Array. doi: 10.1164/rccm.202001-0135OC. Epub 2020 07 24
extensively drug-resistant tuberculosis interim outcome multidrug-resistant tuberculosis rifampicin-resistant tuberculosis sputum conversion

Magnitude of screening for gestational diabetes mellitus in an urban setting in Tanzania; a cross-sectional analytic study.


BACKGROUND: Medical screening detects risk factors for disease or presence of disease in otherwise well persons in order to intervene early and reduce morbidity and mortality.

Authors: Mukuve A Noorani M Sendagire I Mgonja M
Journal Reference: BMC pregnancy and childbirth 2020 Jul 23; 20(1); 418. doi: 10.1186/s12884-020-03115-3. Epub 2020 07 23
Hyperglycaemia in pregnancy Screening Tanzania

Prevalence, associated factors and clinical features of congenital syphilis among newborns in Mbarara hospital, Uganda.


BACKGROUND: While congenital syphilis is a significant public health problem that can cause severe disabilities, little is known about the situation in Uganda.

Authors: Oloya S Lyczkowski D Orikiriza P Irama M Boum Y Migisha R Kiwanuka JP Mwanga-Amumpaire J
Journal Reference: BMC pregnancy and childbirth 2020 Jul 02; 20(1); 385. doi: 10.1186/s12884-020-03047-y. Epub 2020 07 02
Adverse outcome Stillbirth Syphilis; congenital syphilis

Clinical and epidemiological performance of WHO Ebola case definitions: a systematic review and meta-analysis.


BACKGROUND: Ebola virus disease case definition is a crucial surveillance tool to detect suspected cases for referral and as a screening tool for clinicians to support admission and laboratory testing decisions at Ebola health faciliti

Authors: Caleo G Theocharaki F Lokuge K Weiss HA Inamdar L Grandesso F Danis K Pedalino B Kobinger G Sprecher A Greig J Di Tanna GL
Journal Reference: The Lancet. Infectious diseases 2020 Jun 25; (); Array. doi: 10.1016/S1473-3099(20)30193-6. Epub 2020 06 25

HIV epidemic and cascade of care in 12 east African rural fishing communities: results from a population-based survey in Uganda.


BACKGROUND: In East Africa, fishing communities are considered most-at-risk populations for the acquisition of HIV.

Authors: Burgos-Soto J Ben Farhat J Alley I Ojuka P Mulogo E Kise-Sete T Bouhenia M Salumu L Mathela R Langendorf C Cohuet S Huerga H
Journal Reference: BMC public health 2020 Jun 19; 20(1); 970. doi: 10.1186/s12889-020-09121-6. Epub 2020 06 19
Africa Antiretroviral therapy Cascade of care Communities Diagnosis Epidemic Fishing HIV Viral suppression

Systematic or Test-Guided Treatment for Tuberculosis in HIV-Infected Adults.


BACKGROUND: In regions with high burdens of tuberculosis and human immunodeficiency virus (HIV), many HIV-infected adults begin antiretroviral therapy (ART) when they are already severely immunocompromised.

Authors: Blanc FX Badje AD Bonnet M Gabillard D Messou E Muzoora C Samreth S Nguyen BD Borand L Domergue A Rapoud D Natukunda N Thai S Juchet S Eholié SP Lawn SD Domoua SK Anglaret X Laureillard D
Journal Reference: The New England journal of medicine 2020 06 18; 382(25); 2397-2410. doi: 10.1056/NEJMoa1910708. Epub 2020 06 19

Humoral and cellular immune response induced by rVSVΔG-ZEBOV-GP vaccine among frontline workers during the 2013-2016 West Africa Ebola outbreak in Guinea.


BACKGROUND: As part of a Phase III trial with the Ebola vaccine rVSVΔG-ZEBOV-GP in Guinea, we invited frontline workers (FLWs) to participate in a sub-study to provide additional information on the immunogenicity of the vaccine.

Authors: Boum Y Juan-Giner A Hitchings M Soumah A Strecker T Sadjo M Cuthbertson H Hayes P Tchaton M Jemmy JP Clarck C King D Faga EM Becker S Halis B Gunnstein N Carroll M Røttingen JA Kondé MK Doumbia M Henao-Restrepo AM Kieny MP Cisse M Draguez B Grais RF
Journal Reference: Vaccine 2020 Jun 01; (); Array. doi: 10.1016/j.vaccine.2020.04.066. Epub 2020 06 01
Cellular response Ebola vaccine Frontline workers Humoral response Immunogenicity

To fast or not to fast: Lipid measurement and cardiovascular disease risk estimation in rural sub-Saharan Africa.


Background: Cardiovascular disease (CVD) morbidity and mortality are increasing in sub-Saharan Africa (sSA), highlighting the need for tools to enable CVD risk stratification in the region.

Authors: Yang IT Hemphill LC Kim JH Bibangambah P Sentongo R Kakuhire B Plutzky J Boum Y Tsai AC Okello S Siedner MJ
Journal Reference: Journal of global health 2020 Jun ; 10(1); 010407. doi: 10.7189/jogh.10.010407. Epub 2020 04 15