Publications

Evaluating newly approved drugs for multidrug-resistant tuberculosis (endTB): study protocol for an adaptive, multi-country randomized controlled trial.

Abstract

BACKGROUND: Treatment of multidrug- and rifampin-resistant tuberculosis (MDR/RR-TB) is expensive, labour-intensive, and associated with substantial adverse events and poor outcomes.

Guglielmetti L Ardizzoni E Atger M Baudin E Berikova E Bonnet M Chang E Cloez S Coit JM Cox V de Jong BC Delifer C Do JM Tozzi DDS Ducher V Ferlazzo G Gouillou M Khan A Khan U Lachenal N LaHood AN Lecca L Mazmanian M McIlleron H Moschioni M O'Brien K Okunbor O Oyewusi L Panda S Patil SB Phillips PPJ Pichon L Rupasinghe P Rich ML Saluhuddin N Seung KJ Tamirat M Trippa L Cellamare M Velásquez GE Wasserman S Zimetbaum PJ Varaine F Mitnick CD
Trials 2021 Sep 25; 22(1); 651. doi: 10.1186/s13063-021-05491-3. Epub 2021 09 25
Bayesian adaptive randomization Bedaquiline Clofazimine Delamanid Fluoroquinolone Linezolid MDR-TB Non-inferiority Pyrazinamide Rifampicin-resistant tuberculosis Rifampin-resistant tuberculosis Treatment shortening

Exploring the relationships between wasting and stunting among a cohort of children under two years of age in Niger.

Abstract

BACKGROUND: Wasting and stunting, physical growth manifestations of child undernutrition, have historically been considered separately with distinct interventions at the program, policy, and financing levels despite similar risk factor

Kohlmann K Sudfeld CR Garba S Guindo O Grais RF Isanaka S
BMC public health 2021 Sep 21; 21(1); 1713. doi: 10.1186/s12889-021-11689-6. Epub 2021 09 21
Child Concurrence Growth Niger Stunting Undernutrition Wasting

The relationship between wasting and stunting in young children: A systematic review.

Abstract

In 2014, the Emergency Nutrition Network published a report on the relationship between wasting and stunting.

Thurstans S Sessions N Dolan C Sadler K Cichon B Isanaka S Roberfroid D Stobaugh H Webb P Khara T
Maternal & child nutrition 2021 Sep 05; e13246. doi: 10.1111/mcn.13246. Epub 2021 09 05
child growth infectious disease international child health nutrition malnutrition stunting wasting

Pneumococcal Meningitis Outbreaks in Africa, 2000-2018: Systematic Literature Review and Meningitis Surveillance Database Analyses.

Abstract

BACKGROUND: The meningitis belt of sub-Saharan Africa has traditionally experienced large outbreaks of meningitis mainly caused by Neisseria meningitidis.

Franklin K Kwambana-Adams B Lessa FC Soeters HM Cooper L Coldiron ME Mwenda J Antonio M Nakamura T Novak R Cohen AL
The Journal of infectious diseases 2021 Sep 01; 224(Supplement_3); S174-S183. doi: 10.1093/infdis/jiab105. Epub 2021 09 01
Africa Streptococcus pneumoniae meningitis outbreak pneumococcus

Etiology and Incidence of Moderate-to-Severe Diarrhea in Young Children in Niger.

Abstract

BACKGROUND: High-resolution data on the etiology of childhood diarrhea in countries with the highest burden and mortality remain sparse and are needed to inform burden estimates and prioritize interventions.

Platts-Mills JA Houpt ER Liu J Zhang J Guindo O Sayinzoga-Makombe N McMurry TL Elwood S Langendorf C Grais RF Isanaka S
Journal of the Pediatric Infectious Diseases Society 2021 Sep 01; . doi: 10.1093/jpids/piab080. Epub 2021 09 01

Cryptosporidium

Shigella
children diarrhea rotavirus

An exploratory qualitative study of caregivers' knowledge, perceptions and practices related to hospital hygiene in rural Niger.

Abstract

Background: The risk of healthcare-associated infections is exacerbated by poor hygiene practices in health care facilities and can contribute to increased patient morbidity and mortality.

Marquer C Guindo O Mahamadou I Job E Rattigan SM Langendorf C Grais RF Isanaka S
Infection prevention in practice 2021 Sep ; 3(3); 100160. doi: 10.1016/j.infpip.2021.100160. Epub 2021 07 03
Caregiver knowledge Hospital Hygiene Niger Qualitative Severe acute malnutrition

Investigating the link between Alpha-1 Antitrypsin Deficiency and Abdominal Aortic Aneurysms.

Abstract

OBJECTIVES: Alpha-1-Antitrypsin (AAT) is one of the major plasmatic protease inhibitors. In the last decade, an association between Alpha-1-Antitrypsin Deficiency (AATD) and Abdominal Aortic Aneurysms (AAA) has been hypothesized.

Pini L Peroni M Zanotti C Pini A Bossoni E Giordani J Bargagli E Perger E Ferrarotti I Vizzardi E Tiberio L Bonardelli S Tantucci C
Annals of vascular surgery 2021 Aug 26; . doi: 10.1016/j.avsg.2021.05.064. Epub 2021 08 26
Abdominal Aortic Aneurysm Allelic Variants Alpha-1 Antitrypsin Deficiency Genotyping Vascular Disease
Burns R Venables E Odhoch L Kocholla L Wanjala S Mucinya G Bossard C Wringe A
AIDS care 2021 Aug 26; 1-8. doi: 10.1080/09540121.2021.1966697. Epub 2021 08 26
Advanced HIV Democratic Republic of the Congo Kenya hospitalised patients people living with HIV

Development of a dosing-adjustment tool for fluoroquinolones in osteoarticular infections: The Fluo-pop study.

Abstract

Fluoroquinolones efficacy depend on both the drug exposure and the level of drug resistance of the bacteria responsible for the infection.

Lemaitre F Fily F Foulquier JB Revest M Jullien V Petitcollin A Tattevin P Tron C Polard JL Verdier MC Comets E Huten D Arvieux C Bellissant E Laviolle B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug 19; 142 112053. doi: 10.1016/j.biopha.2021.112053. Epub 2021 08 19
Bone infection Joint infection Modeling Ofloxacin Pharmacokinetics