Hand hygiene compliance and environmental contamination with gram-negative bacilli in a rural hospital in Madarounfa, Niger.


BACKGROUND: Healthcare-associated infections pose a major, yet often preventable risk to patient safety.

Authors: Tang K Berthé F Nackers F Hanson K Mambula C Langendorf C Marquer C Isanaka S
Journal Reference: Transactions of the Royal Society of Tropical Medicine and Hygiene 2019 Oct 14; (); Array. doi: 10.1093/trstmh/trz070. Epub 2019 10 14
Niger gram-negative bacilli hand hygiene healthcare personnel healthcare-associated infections

Factors influencing participation in an Ebola vaccine trial among front-line workers in Guinea.


BACKGROUND: Alongside the clinical aspects of the immunogenicity and safety trial of an Ebola vaccine deployed among front-line workers, a qualitative study was conducted to describe motivations behind individuals' decisions to partici

Authors: Grantz KH Claudot P Kambala M Kouyaté M Soumah A Boum Y Juan-Giner A Jemmy JP Cummings DAT Grais RF
Journal Reference: Vaccine 2019 Oct 14; (); Array. doi: 10.1016/j.vaccine.2019.09.094. Epub 2019 10 14
Ebola virus disease Guinea Healthcare workers Qualitative Research design rVSV vaccine

Mobile community-based active case-finding for tuberculosis among older populations in rural Cambodia.


To systematically screen older rural populations in Cambodia for tuberculosis (TB) and develop an effective active case-finding (ACF) model for this TB high-risk group.

Authors: Camelique O Scholtissen S Dousset JP Bonnet M Bastard M Hewison C
Journal Reference: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2019 Oct 01; 23(10); 1107-1114. doi: 10.5588/ijtld.18.0611. Epub 2019 10 19

What is the best culture conversion prognostic marker for patients treated for multidrug-resistant tuberculosis?


Identification of good prognostic marker for tuberculosis (TB) treatment response is a necessary step on the path towards a surrogate marker to reduce TB trial duration.

Authors: Bastard M Sanchez-Padilla E Hayrapetyan A Kimenye K Khurkhumal S Dlamini T Fadul Perez S Telnov A Hewison C Varaine F Bonnet M
Journal Reference: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2019 Oct 01; 23(10); 1060-1067. doi: 10.5588/ijtld.18.0649. Epub 2019 10 19

Beyond wasted and stunted-a major shift to fight child undernutrition.


Child undernutrition refers broadly to the condition in which food intake is inadequate to meet a child's needs for physiological function, growth, and the capacity to respond to illness.

Authors: Wells JCK Briend A Boyd EM Berkely JA Hall A Isanaka S Webb P Khara T Dolan C
Journal Reference: The Lancet. Child & adolescent health 2019 Sep 11; (); Array. doi: 10.1016/S2352-4642(19)30244-5. Epub 2019 09 11

Measles seroprevalence after reactive vaccination campaigns during the 2015 measles outbreak in four health zones of the former Katanga Province, Democratic Republic of Congo.


BACKGROUND: Measles continues to circulate in the Democratic Republic of Congo, and the country suffered from several important outbreaks over the last 5 years.

Authors: Keating P Carrion Martin AI Blake A Lechevalier P Uzzeni F Gignoux E Okonta C Langendorf C Smit S Ahuka S Suchard M Pukuta E Degail MA Hansen L Kibanza-Kyungu J Ciglenecki I Cohuet S
Journal Reference: BMC public health 2019 Aug 22; 19(1); 1153. doi: 10.1186/s12889-019-7500-z. Epub 2019 08 22
Democratic Republic of Congo Immunity Measles Seroprevalence Vaccination

Comparative assessment of methicillin resistant Staphylococcus aureus diagnostic assays for use in resource-limited settings.


BACKGROUND: The rise of methicillin-resistant Staphylococcus aureus (MRSA) is a global health concern.

Authors: Ayebare A Bebell LM Bazira J Ttendo S Katawera V Bangsberg DR Siedner MJ Firth PG Boum Ii Y
Journal Reference: BMC microbiology 2019 Aug 22; 19(1); 194. doi: 10.1186/s12866-019-1566-8. Epub 2019 08 22
Africa Carriage Chromogenic agar MRSA Methicillin-resistant Staphylococcus aureus PCR

The endTB observational study protocol: treatment of MDR-TB with bedaquiline or delamanid containing regimens.


BACKGROUND: At a time when programs were struggling to design effective regimens for the treatment of multidrug-resistant tuberculosis (MDR-TB), the marketing authorization of bedaquiline and delamanid was a critical development in the

Authors: Khan U Huerga H Khan AJ Mitnick CD Hewison C Varaine F Bastard M Rich M Franke MF Atwood S Khan PY Seung KJ
Journal Reference: BMC infectious diseases 2019 Aug 20; 19(1); 733. doi: 10.1186/s12879-019-4378-4. Epub 2019 08 20
Bedaquiline Delamanid Efficacy MDR-TB Safety

Point-of-care viral load monitoring: outcomes from a decentralized HIV programme in Malawi.


INTRODUCTION: Routinely monitoring the HIV viral load (VL) of people living with HIV (PLHIV) on anti-retroviral therapy (ART) facilitates intensive adherence counselling and faster ART regimen switch when treatment failure is indicated

Authors: Nicholas S Poulet E Wolters L Wapling J Rakesh A Amoros I Szumilin E Gueguen M Schramm B
Journal Reference: Journal of the International AIDS Society 2019 Aug ; 22(8); e25387. doi: 10.1002/jia2.25387. Epub 2019 08 23

90-90-90 Decentralization HIV Care Continuum Health System Strengthening Treatment failure Treatment monitoring