Outbreak of Pneumococcal Meningitis, Paoua Subprefecture, Central African Republic, 2016-2017.


We report a pneumococcal meningitis outbreak in the Central African Republic (251 suspected cases; 60 confirmed by latex agglutination test) in 2016-2017. Case-fatality rates (10% for confirmed case-patients) were low.

Authors: Coldiron ME Touré O Frank T Bouygues N Grais RF
Journal Reference: Emerging infectious diseases 2018 09 ; 24(9); 1720-1722. doi: 10.3201/eid2409.171058. Epub 2019 01 18
Central African Republic Streptococcus pneumoniae bacteria meningitis meningitis/encephalitis outbreak pneumococcal meningitis pneumococcal vaccines

Micro-Hotspots of Risk in Urban Cholera Epidemics.


Targeted interventions have been delivered to neighbors of cholera cases in major epidemic responses globally despite limited evidence for the impact of such targeting.

Authors: Azman AS Luquero FJ Salje H Mbaïbardoum NN Adalbert N Ali M Bertuzzo E Finger F Toure B Massing LA Ramazani R Saga B Allan M Olson D Leglise J Porten K Lessler J
Journal Reference: The Journal of infectious diseases 2018 Aug 24; 218(7); 1164-1168. doi: 10.1093/infdis/jiy283. Epub 2018 11 14

Voluntary Community Human Immunodeficiency Virus Testing, Linkage, and Retention in Care Interventions in Kenya: Modeling the Clinical Impact and Cost-effectiveness.


Background: In southwest Kenya, the prevalence of human immunodeficiency virus (HIV) infection is about 25%.

Authors: Luong Nguyen LB Yazdanpanah Y Maman D Wanjala S Vandenbulcke A Price J Parker RA Hennequin W Mendiharat P Freedberg KA
Journal Reference: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018 Aug 16; 67(5); 719-726. doi: 10.1093/cid/ciy173. Epub 2018 11 14

A dynamic model of transmission and elimination of peste des petits ruminants in Ethiopia.


Peste des petits ruminants (PPR), a devastating viral disease of sheep and goats, has been targeted by the global community for eradication within the next 15 years.

Authors: Fournié G Waret-Szkuta A Camacho A Yigezu LM Pfeiffer DU Roger F
Journal Reference: Proceedings of the National Academy of Sciences of the United States of America 2018 08 14; 115(33); 8454-8459. doi: 10.1073/pnas.1711646115. Epub 2018 07 27
control elimination eradication mathematical model vaccination

Acceptability and Utilization of Three Nutritional Supplements during Pregnancy: Findings from a Longitudinal, Mixed-Methods Study in Niger.


Nutritional status in pregnancy is a key determinant of birth outcomes. In low-income countries, maternal diets are often limited, and daily nutrient supplements are recommended to fill nutrient gaps.

Authors: Clermont A Kodish SR Matar Seck A Salifou A Rosen J Grais RF Isanaka S
Journal Reference: Nutrients 2018 Aug 12; 10(8); Array. doi: 10.3390/nu10081073. Epub 2018 08 12
Niger diet maternal nutrition pregnancy outcomes prenatal supplement qualitative methods

Depression and Suicidal Ideation Among HIV-Infected Adults Receiving Efavirenz Versus Nevirapine in Uganda: A Prospective Cohort Study.


Background: Evidence regarding potential adverse neuropsychiatric effects of efavirenz is conflicting, and data from sub-Saharan Africa, where 70% of persons living with HIV (PLHIV) reside and efavirenz is used as first-line therapy, a

Authors: Chang JL Tsai AC Musinguzi N Haberer JE Boum Y Muzoora C Bwana M Martin JN Hunt PW Bangsberg DR Siedner MJ
Journal Reference: Annals of internal medicine 2018 Aug 07; 169(3); 146-155. doi: 10.7326/M17-2252. Epub 2018 06 26

Xpert MTB/RIF diagnosis of childhood tuberculosis from sputum and stool samples in a high TB-HIV-prevalent setting.


The Xpert MTB/RIF assay is a major advance for diagnosis of tuberculosis (TB) in high-burden countries but is limited in children by their difficulty to produce sputum.

Authors: Orikiriza P Nansumba M Nyehangane D Bastard M Mugisha IT Nansera D Mwanga-Amumpaire J Boum Y Kumbakumba E Bonnet M
Journal Reference: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2018 Aug ; 37(8); 1465-1473. doi: 10.1007/s10096-018-3272-0. Epub 2018 05 08
Childhood tuberculosis Sputum Stool Xpert MTB/RIF

Evaluation of the SD bioline cholera rapid diagnostic test during the 2016 cholera outbreak in Lusaka, Zambia.


OBJECTIVE: To assess the performance of the SD Bioline Cholera Ag O1/O139 rapid diagnostic test (RDT) compared to a reference standard combining culture and PCR for the diagnosis of cholera cases during an outbreak.

Authors: Mwaba J Ferreras E Chizema-Kawesa E Mwimbe D Tafirenyika F Rauzier J Blake A Rakesh A Poncin M Stoitsova S Kwenda G Azman AS Chewe O Serafini M Lukwesa-Musyani C Cohuet S Quilici ML Luquero FJ Page AL
Journal Reference: Tropical medicine & international health : TM & IH 2018 Aug ; 23(8); 834-840. doi: 10.1111/tmi.13084. Epub 2018 06 29
cholera choléra diagnostic accuracy outbreak précision diagnostique rapid diagnostic test test de diagnostic rapide épidémie

Distribution and Performance of Cardiovascular Risk Scores in a Mixed Population of HIV-Infected and Community-Based HIV-Uninfected Individuals in Uganda.


BACKGROUND: The utility and validity of cardiovascular diseases (CVD) risk scores are not well studied in sub-Saharan Africa.

Authors: Muiru AN Bibangambah P Hemphill L Sentongo R Kim JH Triant VA Bangsberg DR Tsai AC Martin JN Haberer JE Boum Y Plutzky J Hunt PW Okello S Siedner MJ
Journal Reference: Journal of acquired immune deficiency syndromes (1999) 2018 Aug 01; 78(4); 458-464. doi: 10.1097/QAI.0000000000001696. Epub 2018 11 14