Publications

Treatment initiation, program attrition and patient treatment outcomes associated with scale-up and decentralization of HIV care in rural Malawi.

Abstract

OBJECTIVE: To describe patient antiretroviral therapy (cART) outcomes associated with intensive decentralization of services in a rural HIV program in Malawi.

McGuire M Pinoges L Kanapathipillai R Munyenyembe T Huckabee M Makombe S Szumilin E Heinzelmann A Pujades-Rodríguez M
PloS one 2012 ; 7(10); e38044. doi: 10.1371/journal.pone.0038044. Epub 2012 10 15

Burden of visceral leishmaniasis in villages of eastern Gedaref State, Sudan: an exhaustive cross-sectional survey.

Abstract

BACKGROUND: Since December 2009, Médecins Sans Frontières has diagnosed and treated patients with visceral leishmaniasis (VL) in Tabarak Allah Hospital, eastern Gedaref State, one of the main endemic foci of VL in Sudan.

Mueller YK Nackers F Ahmed KA Boelaert M Djoumessi JC Eltigani R Gorashi HA Hammam O Ritmeijer K Salih N Worku D Etard JF Chappuis F
PLoS neglected tropical diseases 2012 ; 6(11); e1872. doi: 10.1371/journal.pntd.0001872. Epub 2012 11 01

Adherence to self-administered tuberculosis treatment in a high HIV-prevalence setting: a cross-sectional survey in Homa Bay, Kenya.

Abstract

BACKGROUND: Good adherence to treatment is crucial to control tuberculosis (TB). Efficiency and feasibility of directly observed therapy (DOT) under routine program conditions have been questioned.

Nackers F Huerga H Espié E Aloo AO Bastard M Etard JF Sitienei J Varaine F Chakaya J Bonnet M
PloS one 2012 ; 7(3); e32140. doi: 10.1371/journal.pone.0032140. Epub 2012 03 12

Early prediction of treatment efficacy in second-stage gambiense human African trypanosomiasis.

Abstract

BACKGROUND: Human African trypanosomiasis is fatal without treatment. The long post-treatment follow-up (24 months) required to assess cure complicates patient management and is a major obstacle in the development of new therapies.

Priotto G Chappuis F Bastard M Flevaud L Etard JF
PLoS neglected tropical diseases 2012 ; 6(6); e1662. doi: 10.1371/journal.pntd.0001662. Epub 2012 06 05

Efficacy of fixed-dose combination artesunate-amodiaquine versus artemether-lumefantrine for uncomplicated childhood Plasmodium falciparum malaria in Democratic Republic of Congo: a randomized non-inferiority trial.

Abstract

BACKGROUND: In 2005, the Democratic Republic of Congo (DRC) adopted artesunate and amodiaquine (ASAQ) as first-line anti-malarial treatment.

Espié E Lima A Atua B Dhorda M Flévaud L Sompwe EM Palma Urrutia PP Guerin PJ
Malaria journal 2012 May 25; 11 174. doi: 10.1186/1475-2875-11-174. Epub 2012 05 25

Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial.

Abstract

BACKGROUND: Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce.

Muehlenbachs A Nabasumba C McGready R Turyakira E Tumwebaze B Dhorda M Nyehangane D Nalusaji A Nosten F Guerin PJ Piola P
Malaria journal 2012 May 03; 11 150. doi: 10.1186/1475-2875-11-150. Epub 2012 05 03

Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial.

Abstract

BACKGROUND: Data from the largest randomized, controlled trial for the treatment of children hospitalized with severe malaria were used to identify such predictors of a poor outcome from severe malaria.

von Seidlein L Olaosebikan R Hendriksen IC Lee SJ Adedoyin OT Agbenyega T Nguah SB Bojang K Deen JL Evans J Fanello CI Gomes E Pedro AJ Kahabuka C Karema C Kivaya E Maitland K Mokuolu OA Mtove G Mwanga-Amumpaire J Nadjm B Nansumba M Ngum WP Onyamboko MA Reyburn H Sakulthaew T Silamut K Tshefu AK Umulisa N Gesase S Day NP White NJ Dondorp AM
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012 Apr ; 54(8); 1080-90. doi: 10.1093/cid/cis034. Epub 2012 03 12