Publications

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ENG

An intensive model of care for hepatitis C virus screening and treatment with direct-acting antivirals in people who inject drugs in Nairobi, Kenya: A model-based cost-effectiveness analysis.

Abstract

BACKGROUND AND AIMS: Hepatitis C virus (HCV) treatment is essential for eliminating HCV in people who inject drugs (PWID) but has limited coverage in resource-limited settings.

Auteurs: Mafirakureva N Stone J Fraser H Nzomukunda Y Maina A Thiong'o AW Kizito KW Mucara EWK González Diaz CI Musyoki H Mundia B Cherutich P Nyakowa M Lizcano J Chhun N Kurth A Akiyama MJ Waruiru W Bhattacharjee P Cleland C Donchuk D Luhmann N Loarec A Maman D Walker J Vickerman P
Référence de l'article: Addiction (Abingdon, England) 2021 Jun 29; (); Array. doi: 10.1111/add.15630. Epub 2021 06 29
HCV cost-effectiveness direct-acting antiviral treatment low-income setting people who inject drugs
ENG

Population pharmacokinetics and significant under-dosing of anti-tuberculosis medications in people with HIV and Critical Illness.

Abstract

Critical illness from tuberculosis (TB) bloodstream infection results in a high case fatality rate for people living with human immunodeficiency virus (HIV). Critical illness can lead to altered pharmacokinetics and suboptimal drug exposures.

Auteurs: Prakruti S. Rao Christopher C. Moore Amir A. Mbonde Edwin Nuwagira Patrick Orikiriza Dan Nyehangane et al.
Référence de l'article: Antibiotics 2021, 10(6), 739; https://doi.org/10.3390/antibiotics10060739
Tuberculosis HIV
ENG

Regional sequencing collaboration reveals persistence of the T12 O1 lineage in West Africa.

Abstract

Background: Despite recent insights into cholera transmission patterns in Africa, regional and local dynamics in West Africa-where cholera outbreaks occur every few years-are still poorly understood.

Auteurs: Ekeng E Tchatchouang S Akenji B Issaka BB Akintayo I Chukwu C Dano ID Melingui S Ousmane S Popoola MO Nzouankeu A Boum Y Luquero F Ahumibe A Naidoo D Azman A Lessler J Wohl S
Référence de l'article: eLife 2021 Jun 18; 10(); Array. doi: 10.7554/eLife.65159. Epub 2021 06 18
Vibrio cholerae West Africa antimicrobial resistance epidemiology genetics genomics global health transmission
ENG

All-oral longer regimens are effective for the management of multidrug resistant tuberculosis in high burden settings.

Abstract

BACKGROUND: Recent World Health Organisation guidance on drug-resistant tuberculosis treatment de-prioritised injectable agents, in use for decades, and endorsed all-oral longer regimens.

Auteurs: Khan PY Franke MF Hewison C Seung KJ Huerga H Atwood S Ahmed S Khan M Sultana T Manzur-Ul-Alam M Vo LNQ Lecca L Yae K Kozhabekov S Tamirat M Gelin A Vilbrun SC Kikvidze M Faqirzai J Kadyrov A Skrahina A Mesic A Avagyan N Bastard M Rich ML Khan U Mitnick CD
Référence de l'article: The European respiratory journal 2021 Jun 17; (); Array. doi: 10.1183/13993003.04345-2020. Epub 2021 06 17
ENG

Tuberculosis diagnostic accuracy of stool Xpert MTB/RIF and urine AlereLAM in vulnerable children.

Abstract

BACKGROUND: Non-sputum based diagnostic approaches are crucial in children at high risk of disseminated tuberculosis [TB] who cannot expectorate sputum.

Auteurs: Orikiriza P Smith J Ssekyanzi B Nyehangane D Mugisha Taremwa I Turyashemererwa E Byamukama O Tusabe T Ardizzoni E Marais BJ Wobudeya E Kemigisha E Mwanga-Amumpaire J Nampijja D Bonnet M
Référence de l'article: The European respiratory journal 2021 Jun 17; (); Array. doi: 10.1183/13993003.01116-2021. Epub 2021 06 17
ENG

Effects of short-term exposure to particulate matter on emergency department admission and hospitalization for asthma exacerbations in Brescia district.

Abstract

BACKGROUND: Rising pollution plays a crucial role in worsening several respiratory diseases. Particulate Matter (PM)-induced asthma exacerbations are one of the most dangerous events.

Auteurs: Pini L Giordani J Concoreggi C Zanardini E Pini A Perger E Bargagli E Di Bona D Ciarfaglia M Tantucci C
Référence de l'article: The Journal of asthma : official journal of the Association for the Care of Asthma 2021 Jun 14; (); 1-8. doi: 10.1080/02770903.2021.1929310. Epub 2021 06 14
PM10 PM2.5 Particulate matter airborne pollutants asthma asthma exacerbation emergency department hospitalization
ENG

Treated HIV Infection and Progression of Carotid Atherosclerosis in Rural Uganda: A Prospective Observational Cohort Study.

Abstract

Background Although ≈70% of the world's population of people living with HIV reside in sub-Saharan Africa, there are minimal prospective data on the contributions of HIV infection to atherosclerosis in the region.

Auteurs: Siedner MJ Bibangambah P Kim JH Lankowski A Chang JL Yang IT Kwon DS North CM Triant VA Longenecker C Ghoshhajra B Peck RN Sentongo RN Gilbert R Kakuhikire B Boum Y Haberer JE Martin JN Tracy R Hunt PW Bangsberg DR Tsai AC Hemphill LC Okello S
Référence de l'article: Journal of the American Heart Association 2021 Jun 05; (); e019994. doi: 10.1161/JAHA.120.019994. Epub 2021 06 05
HIV infection Uganda antiretroviral therapy atherosclerosis cardiovascular disease risk carotid intima media thickness
ENG

STI prevalence among men living with HIV engaged in safer conception care in rural, southwestern Uganda.

Abstract

HIV care provides an opportunity to integrate comprehensive sexual and reproductive healthcare, including sexually transmitted infection (STI) management.

Auteurs: Chitneni P Bwana MB Muyindike W Owembabazi M Kalyebara PK Byamukama A Mbalibulha Y Smith PM Hsu KK Haberer JE Kaida A Matthews LT
Référence de l'article: PloS one 2021 ; 16(3); e0246629. doi: 10.1371/journal.pone.0246629. Epub 2021 03 03
ENG

Potential value of urine lateral-flow lipoarabinomannan (LAM) test for diagnosing tuberculosis among severely acute malnourished children.

Abstract

BACKGROUND: Tuberculosis (TB) is a serious co-morbidity among children with severe acute malnutrition (SAM) and TB diagnosis remains particularly challenging in the very young.

Auteurs: Schramm B Nganaboy RC Uwiragiye P Mukeba D Abdoubara A Abdou I Nshimiymana JC Sounna S Hiffler L Flevaud L Huerga H
Référence de l'article: PloS one 2021 ; 16(5); e0250933. doi: 10.1371/journal.pone.0250933. Epub 2021 05 05