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An exploratory qualitative study of caregivers' knowledge, perceptions and practices related to hospital hygiene in rural Niger.


Background: The risk of healthcare-associated infections is exacerbated by poor hygiene practices in health care facilities and can contribute to increased patient morbidity and mortality.

Marquer C Guindo O Mahamadou I Job E Rattigan SM Langendorf C Grais RF Isanaka S
Infection prevention in practice 2021 Sep ; 3(3); 100160. doi: 10.1016/j.infpip.2021.100160. Epub 2021 07 03
Caregiver knowledge Hospital Hygiene Niger Qualitative Severe acute malnutrition

Etiology and Incidence of Moderate-to-Severe Diarrhea in Young Children in Niger.


BACKGROUND: High-resolution data on the etiology of childhood diarrhea in countries with the highest burden and mortality remain sparse and are needed to inform burden estimates and prioritize interventions.

Platts-Mills JA Houpt ER Liu J Zhang J Guindo O Sayinzoga-Makombe N McMurry TL Elwood S Langendorf C Grais RF Isanaka S
Journal of the Pediatric Infectious Diseases Society 2021 Sep 01; doi: 10.1093/jpids/piab080. Epub 2021 09 01


children diarrhea rotavirus

Pneumococcal Meningitis Outbreaks in Africa, 2000-2018: Systematic Literature Review and Meningitis Surveillance Database Analyses.


BACKGROUND: The meningitis belt of sub-Saharan Africa has traditionally experienced large outbreaks of meningitis mainly caused by Neisseria meningitidis.

Franklin K Kwambana-Adams B Lessa FC Soeters HM Cooper L Coldiron ME Mwenda J Antonio M Nakamura T Novak R Cohen AL
The Journal of infectious diseases 2021 Sep 01; 224(Supplement_3); S174-S183. doi: 10.1093/infdis/jiab105. Epub 2021 09 01
Africa Streptococcus pneumoniae meningitis outbreak pneumococcus
Burns R Venables E Odhoch L Kocholla L Wanjala S Mucinya G Bossard C Wringe A
AIDS care 2021 Aug 26; 1-8. doi: 10.1080/09540121.2021.1966697. Epub 2021 08 26
Advanced HIV Democratic Republic of the Congo Kenya hospitalised patients people living with HIV

Investigating the link between Alpha-1 Antitrypsin Deficiency and Abdominal Aortic Aneurysms.


OBJECTIVES: Alpha-1-Antitrypsin (AAT) is one of the major plasmatic protease inhibitors. In the last decade, an association between Alpha-1-Antitrypsin Deficiency (AATD) and Abdominal Aortic Aneurysms (AAA) has been hypothesized.

Pini L Peroni M Zanotti C Pini A Bossoni E Giordani J Bargagli E Perger E Ferrarotti I Vizzardi E Tiberio L Bonardelli S Tantucci C
Annals of vascular surgery 2021 Aug 26; doi: 10.1016/j.avsg.2021.05.064. Epub 2021 08 26
Abdominal Aortic Aneurysm Allelic Variants Alpha-1 Antitrypsin Deficiency Genotyping Vascular Disease

Development of a dosing-adjustment tool for fluoroquinolones in osteoarticular infections: The Fluo-pop study.


Fluoroquinolones efficacy depend on both the drug exposure and the level of drug resistance of the bacteria responsible for the infection.

Lemaitre F Fily F Foulquier JB Revest M Jullien V Petitcollin A Tattevin P Tron C Polard JL Verdier MC Comets E Huten D Arvieux C Bellissant E Laviolle B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug 19; 142 112053. doi: 10.1016/j.biopha.2021.112053. Epub 2021 08 19
Bone infection Joint infection Modeling Ofloxacin Pharmacokinetics

A feasibility study using mid-upper arm circumference as the sole anthropometric criterion for admission and discharge in the outpatient treatment for severe acute malnutrition.


BACKGROUND: The World Health Organization recommends the use of a weight-for-height Z-score (WHZ) and/or mid-upper arm circumference (MUAC) as anthropometric criteria for the admission and discharge of young children for the community-

Garba S Salou H Nackers F Ayouba A Escruela M Guindo O Rocaspana M Grais RF Isanaka S
BMC nutrition 2021 Aug 12; 7(1); 47. doi: 10.1186/s40795-021-00448-w. Epub 2021 08 12
Admission criteria Community-based management of acute malnutrition Discharge criteria Mid-upper arm circumference Niger Severe acute malnutrition Wasting

The HIV cascade of care among serodiscordant couples in four high HIV prevalence settings in sub-Saharan Africa.


BACKGROUND:  HIV-serodiscordant couples are at high risk of HIV transmission. In sub-Saharan Africa, HIV-serodiscordant couples contribute ~30% of all new infections in the region.

Chihana ML Conan N Ellman T Poulet E Garone DB Ortuno R Wanjala S Masiku C Etard JF Davies MA Maman D
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2021 Aug 02; 111(8); . doi: 10.7196/SAMJ.2021.v111i8.15489. Epub 2021 08 02

How to improve outbreak response: a case study of integrated outbreak analytics from Ebola in Eastern Democratic Republic of the Congo.


The emerging field of outbreak analytics calls attention to the need for data from multiple sources to inform evidence-based decision making in managing infectious diseases outbreaks.

Carter SE Ahuka-Mundeke S Pfaffmann Zambruni J Navarro Colorado C van Kleef E Lissouba P Meakin S le Polain de Waroux O Jombart T Mossoko M Bulemfu Nkakirande D Esmail M Earle-Richardson G Degail MA Umutoni C Anoko JN Gobat N
BMJ global health 2021 Aug ; 6(8); doi: 10.1136/bmjgh-2021-006736. Epub 2021 08 20
epidemiology health services research other study design public health viral haemorrhagic fevers