Publications

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Performance of six rapid diagnostic tests for SARS-CoV-2 antigen detection and implications for practical use.

Abstract

BACKGROUND: Direct detection of SARS-CoV-2 viral proteins in nasopharyngeal swabs using lateral flow immunoassays is a simple, fast and cheap approach to diagnose the infection.

Fourati S Langendorf C Audureau E Challine D Michel J Soulier A Ahnou N Désveaux I Picard O Ortonne V Gourgeon A Mills C Hémery F Rieux C Pawlotsky JM Malou N Chevaliez S
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2021 Jul 25; 142 104930. doi: 10.1016/j.jcv.2021.104930. Epub 2021 07 25
Antigen assay COVID-19 Diagnostic Rapid diagnostic test SARS-CoV-2 Screening

Rotavirus vaccine efficacy up to 2 years of age and against diverse circulating rotavirus strains in Niger: Extended follow-up of a randomized controlled trial.

Abstract

BACKGROUND: Rotavirus vaccination is recommended in all countries to reduce the burden of diarrhea-related morbidity and mortality in children.

Isanaka S Langendorf C McNeal MM Meyer N Plikaytis B Garba S Sayinzoga-Makombe N Soumana I Guindo O Makarimi R Scherrer MF Adehossi E Ciglenecki I Grais RF
PLoS medicine 2021 Jul ; 18(7); e1003655. doi: 10.1371/journal.pmed.1003655. Epub 2021 07 02

Serologic response to SARS-CoV-2 in an African population.

Abstract

Official case counts suggest Africa has not seen the expected burden of COVID-19 as predicted by international health agencies, and the proportion of asymptomatic patients, disease severity, and mortality burden differ significantly in Africa from what

Fai KN Corine TM Bebell LM Mboringong AB Nguimbis EBPT Nsaibirni R Mbarga NF Eteki L Nikolay B Essomba RG Ndifon M Ntone R Hamadou A Matchim L Tchiasso D Abah Abah AS Essaka R Peppa S Crescence F Ouamba JP Koku MT Mandeng N Fanne M Eyangoh S Mballa GAE Esso L Epée E Njouom R Okomo Assoumou MC Boum Y
Scientific African 2021 Jul ; 12 e00802. doi: 10.1016/j.sciaf.2021.e00802. Epub 2021 05 30
Africa COVID-19 Immunoglobulin Rapid diagnostic tests Serology

An intensive model of care for hepatitis C virus screening and treatment with direct-acting antivirals in people who inject drugs in Nairobi, Kenya: A model-based cost-effectiveness analysis.

Abstract

BACKGROUND AND AIMS: Hepatitis C virus (HCV) treatment is essential for eliminating HCV in people who inject drugs (PWID) but has limited coverage in resource-limited settings.

Mafirakureva N Stone J Fraser H Nzomukunda Y Maina A Thiong'o AW Kizito KW Mucara EWK González Diaz CI Musyoki H Mundia B Cherutich P Nyakowa M Lizcano J Chhun N Kurth A Akiyama MJ Waruiru W Bhattacharjee P Cleland C Donchuk D Luhmann N Loarec A Maman D Walker J Vickerman P
Addiction (Abingdon, England) 2021 Jun 29; doi: 10.1111/add.15630. Epub 2021 06 29
HCV cost-effectiveness direct-acting antiviral treatment low-income setting people who inject drugs

Population pharmacokinetics and significant under-dosing of anti-tuberculosis medications in people with HIV and Critical Illness.

Abstract

Critical illness from tuberculosis (TB) bloodstream infection results in a high case fatality rate for people living with human immunodeficiency virus (HIV). Critical illness can lead to altered pharmacokinetics and suboptimal drug exposures.

Prakruti S. Rao Christopher C. Moore Amir A. Mbonde Edwin Nuwagira Patrick Orikiriza Dan Nyehangane et al.
Antibiotics 2021, 10(6), 739; https://doi.org/10.3390/antibiotics10060739
Tuberculosis HIV

Regional sequencing collaboration reveals persistence of the T12 O1 lineage in West Africa.

Abstract

Background: Despite recent insights into cholera transmission patterns in Africa, regional and local dynamics in West Africa-where cholera outbreaks occur every few years-are still poorly understood.

Ekeng E Tchatchouang S Akenji B Issaka BB Akintayo I Chukwu C Dano ID Melingui S Ousmane S Popoola MO Nzouankeu A Boum Y Luquero F Ahumibe A Naidoo D Azman A Lessler J Wohl S
eLife 2021 Jun 18; 10 doi: 10.7554/eLife.65159. Epub 2021 06 18
Vibrio cholerae West Africa antimicrobial resistance epidemiology genetics genomics global health transmission

All-oral longer regimens are effective for the management of multidrug resistant tuberculosis in high burden settings.

Abstract

BACKGROUND: Recent World Health Organisation guidance on drug-resistant tuberculosis treatment de-prioritised injectable agents, in use for decades, and endorsed all-oral longer regimens.

Khan PY Franke MF Hewison C Seung KJ Huerga H Atwood S Ahmed S Khan M Sultana T Manzur-Ul-Alam M Vo LNQ Lecca L Yae K Kozhabekov S Tamirat M Gelin A Vilbrun SC Kikvidze M Faqirzai J Kadyrov A Skrahina A Mesic A Avagyan N Bastard M Rich ML Khan U Mitnick CD
The European respiratory journal 2021 Jun 17; doi: 10.1183/13993003.04345-2020. Epub 2021 06 17