In global health research, short-term, small-scale clinical trials with fixed, two-arm trial designs that generally do not allow for major changes throughout the trial are the most common study design.
Evaluating whether an intervention works when trialled in groups of individuals can pose complex challenges for clinical research.
This paper shows the scale of global health research and the context in which we frame the subsequent papers in the Series.
AMR in low-resource settings: Médecins Sans Frontières bridges surveillance gaps by developing a turnkey solution, the Mini-Lab.
BACKGROUND: In low-and-middle-income countries (LMIC), data related to antimicrobial resistance (AMR) are often inconsistently collected.
BACKGROUND: Patients hospitalized with advanced HIV have a high mortality risk.
Epidemiological, clinical, and public health response characteristics of a large outbreak of diphtheria among the Rohingya population in Cox's Bazar, Bangladesh, 2017 to 2019: A retrospective study.
BACKGROUND: Unrest in Myanmar in August 2017 resulted in the movement of over 700,000 Rohingya refugees to overcrowded camps in Cox's Bazar, Bangladesh. A large outbreak of diphtheria subsequently began in this population.
Performance and operational feasibility of antigen and antibody rapid diagnostic tests for COVID-19 in symptomatic and asymptomatic patients in Cameroon: a clinical, prospective, diagnostic accuracy study.
Background: Real-time PCR is recommended to detect SARS-CoV-2 infection. However, PCR availability is restricted in most countries.
Decentralised hepatitis C testing and treatment in rural Cambodia: evaluation of a simplified service model integrated in an existing public health system.
BACKGROUND: Direct-acting antiviral treatment for hepatitis C virus (HCV) has provided the opportunity for simplified models of care delivered in decentralised settings by non-specialist clinical personnel.