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Randomised trials at the level of the individual.


In global health research, short-term, small-scale clinical trials with fixed, two-arm trial designs that generally do not allow for major changes throughout the trial are the most common study design.

Park JJH Ford N Xavier D Ashorn P Grais RF Bhutta ZA Goossens H Thorlund K Socias ME Mills EJ
The Lancet. Global health 2021 May ; 9(5); e691-e700. doi: 10.1016/S2214-109X(20)30540-4. Epub 2021 04 18
Essai clinique

The role and challenges of cluster randomised trials for global health.


Evaluating whether an intervention works when trialled in groups of individuals can pose complex challenges for clinical research.

Dron L Taljaard M Cheung YB Grais R Ford N Thorlund K Jahan F Nakimuli-Mpungu E Xavier D Bhutta ZA Park JJH Mills EJ
The Lancet. Global health 2021 May ; 9(5); e701-e710. doi: 10.1016/S2214-109X(20)30541-6. Epub 2021 04 18
Essai clinique

Urgently seeking efficiency and sustainability of clinical trials in global health.


This paper shows the scale of global health research and the context in which we frame the subsequent papers in the Series.

Park JJH Grais RF Taljaard M Nakimuli-Mpungu E Jehan F Nachega JB Ford N Xavier D Kengne AP Ashorn P Socias ME Bhutta ZA Mills EJ
The Lancet. Global health 2021 May ; 9(5); e681-e690. doi: 10.1016/S2214-109X(20)30539-8. Epub 2021 04 18
Essai clinique

AMR in low-resource settings: Médecins Sans Frontières bridges surveillance gaps by developing a turnkey solution, the Mini-Lab.


BACKGROUND: In low-and-middle-income countries (LMIC), data related to antimicrobial resistance (AMR) are often inconsistently collected.

Ronat JB Natale A Kesteman T Andremont A Elamin W Hardy L Kanapathipillai R Michel J Langendorf C Vandenberg O Naas T Kouassi F
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2021 Apr 28; doi: 10.1016/j.cmi.2021.04.015. Epub 2021 04 28
Antimicrobial resistance Clinical bacteriology laboratory Low-and middle-income countries Mini-lab Médecins Sans Frontières Surveillance

Epidemiological, clinical, and public health response characteristics of a large outbreak of diphtheria among the Rohingya population in Cox's Bazar, Bangladesh, 2017 to 2019: A retrospective study.


BACKGROUND: Unrest in Myanmar in August 2017 resulted in the movement of over 700,000 Rohingya refugees to overcrowded camps in Cox's Bazar, Bangladesh. A large outbreak of diphtheria subsequently began in this population.

Polonsky JA Ivey M Mazhar KA Rahman Z le Polain de Waroux O Karo B Jalava K Vong S Baidjoe A Diaz J Finger F Habib ZH Halder CE Haskew C Kaiser L Khan AS Sangal L Shirin T Zaki QA Salam A White K
PLoS medicine 2021 Apr 01; 18(4); e1003587. doi: 10.1371/journal.pmed.1003587. Epub 2021 04 01

Decentralised hepatitis C testing and treatment in rural Cambodia: evaluation of a simplified service model integrated in an existing public health system.


BACKGROUND: Direct-acting antiviral treatment for hepatitis C virus (HCV) has provided the opportunity for simplified models of care delivered in decentralised settings by non-specialist clinical personnel.

Meiwen Zhang Daniel O’Keefe Jennifer Craig Keo Samley Voeurng Bunreth Pascal Jolivet Suna Balkan Tonia Marquardt Jean-Philippe Dousset Mickael Le Paih
Lancet Gastroenterol Hepatol 2021 Published Online March 18, 2021.
Hépatite C Evaluation Cambodge