Epicentre Niger

Thursday 14 February 2019 - Updated on Thursday 11 April 2019
Epicentre conducts innovative research at its research center in Maradi, Niger.
Maradi, at the heart of Epicentre activity in Niger
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Maradi, at the heart of Epicentre activity in Niger

Epicentre’s research center in Maradi, Niger, was created in the aftermath of the 2005 nutritional crisis in Niger. Epicentre was officially registered in Niger in 2009. As of today, 200 staff members work in various fields: medical care, quality control, laboratory, data management, logistics, and administrative activities among others. The entire staff is from Niger or surrounding countries. In addition to supporting the Ministry of Health, Médecins Sans Frontières (MSF) and other NGOs to respond to outbreaks and nutritional crisis, innovative research studies are also conducted in Maradi and throughout the country.

Research

Trials are conducted according to GCPs (Good Clinical Practices) and GPP (Good Participatory Practices) quality standards. Studies are conducted in close collaboration with the Ministry of Health, MSF, NGOs, CERMES, the University of Niamey, UN agencies and other academic institutions.

Recently, Epicentre conducted a cluster-randomized trial in Niger during a meningococcal group C epidemic in 2017. Villages were randomized to receive either the current WHO standard of care of no antibiotic prophylaxis, household prophylaxis with a single dose of ciprofloxacin, or village-wide (mass) single-dose ciprofloxacin prophylaxis within 72 hours of the notification of the first meningitis case in a village. In light of these data, WHO may consider revising its recommendations to include consideration of targeted mass provision of ciprofloxacin in high–meningitis-burden settings, at least until individuals are vaccinated or the epidemic ends.

Epicentre also conducted a phase III trial for the development of a thermostable rotavirus vaccine (ROTASIIL®). This is an oral vaccine administered to infants in a three-dose course at the same time as routine vaccinations. 
 
Rotavirus is leading cause of diarrhoea in infants due to severe gastroenteritis. The vaccine was prequalified by the World Health Organization in September 2018. The Epicentre study continues and explores long term efficacy and the effect of poor prenatal nutrition on infant immune response to rotavirus and other routine vaccinations.

Other projects conducted in Niger include work on severe malnutrition, meningitis, and Rift Valley Fever outbreak investigation.

Laboratory

The research center in Maradi is also equipped with a laboratory on the grounds of the regional hospital. Bacteriology and serology are performed there along with other routine analyses.

Epicentre laboratory for KWASHIORKOR study (Madarounfa - Niger)

Selected publications

Single-dose oral ciprofloxacin prophylaxis as a response to a meningococcal meningitis epidemic in the African meningitis belt: A 3-arm, open-label, cluster-randomized trial.

Journal Reference: PLoS medicine 2018 Jun ; 15(6); e1002593. doi: 10.1371/journal.pmed.1002593. Epub 2018 06 26

Molecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger.

Journal Reference: Malaria journal 2018 Feb 27; 17(1); 98. doi: 10.1186/s12936-018-2242-4. Epub 2018 02 27

Efficacy of a Low-Cost, Heat-Stable Oral Rotavirus Vaccine in Niger.

Journal Reference: The New England journal of medicine 2017 03 23; 376(12); 1121-1130. doi: 10.1056/NEJMoa1609462. Epub 2017 04 28

Acceptability and Utilization of Three Nutritional Supplements during Pregnancy: Findings from a Longitudinal, Mixed-Methods Study in Niger.

Journal Reference: Nutrients 2018 Aug 12; 10(8); Array. doi: 10.3390/nu10081073. Epub 2018 08 12

The gender, social and cultural influences on the management and use of unconditional cash transfers in Niger: a qualitative study.

Journal Reference: Public health nutrition 2017 Jun ; 20(9); 1657-1665. doi: 10.1017/S1368980017000337. Epub 2017 03 06
See all

Focus on activities in Niger

Scientific day Niger 2018

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Affiche Journée Scientifique Niger 2018

Nutritional diseases

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A baby is being weighed in a village in Chad.

Rotavirus

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Rotavirus vaccine clinical trial

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Meningitis vaccination campaign, Niger
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Meningitis vaccination campaign, Niger
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Laboratory cold room, Maradi, Niger
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Laboratory cold room, Maradi, Niger
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New-born suffering from malnutrition, Niger
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New-born suffering from malnutrition, Niger
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Manipulating test tubes in the laboratory, Maradi, Niger
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Manipulating test tubes in the laboratory, Maradi, Niger
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Dr Ousmane Guindo, Director, Epicentre, Niger
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Dr Ousmane Guindo, Director, Epicentre, Niger