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Immunogenicity and safety of fractional doses of yellow fever vaccines: a randomised, double-blind, non-inferiority trial.


BACKGROUND: Stocks of yellow fever vaccine are insufficient to cover exceptional demands for outbreak response. Fractional dosing has shown efficacy, but evidence is limited to the 17DD substrain vaccine.

Auteurs: Juan-Giner A Kimathi D Grantz KH Hamaluba M Kazooba P Njuguna P Fall G Dia M Bob NS Monath TP Barrett AD Hombach J Mulogo EM Ampeire I Karanja HK Nyehangane D Mwanga-Amumpaire J Cummings DAT Bejon P Warimwe GM Grais RF
Référence de l'article: Lancet (London, England) 2021 Jan 09; 397(10269); 119-127. doi: 10.1016/S0140-6736(20)32520-4. Epub 2021 01 10

Outcomes of AIDS-associated Kaposi sarcoma in Mozambique after treatment with pegylated liposomal doxorubicin.


BACKGROUND: Kaposi's sarcoma (KS) is a common HIV-associated malignancy frequently associated with poor outcomes. It is the most frequently diagnosed cancer in major cities of Mozambique.

Auteurs: Coldiron ME Gutierrez Zamudio AG Manuel R Luciano G Rusch B Ciglenecki I Telnov A Grais RF Trellu LT Molfino L
Référence de l'article: Infectious agents and cancer 2021 Jan 07; 16(1); 2. doi: 10.1186/s13027-020-00341-4. Epub 2021 01 07
AIDS-related opportunistic infections Acquired immunodeficiency syndrome Doxorubicin Kaposi sarcoma Mozambique

Smartphone-Based Ophthalmic Imaging Compared to Spectral Domain Optical Coherence Tomography Assessment of Vertical Cup-to-Disc Ratio among Adults in Southwestern Uganda.


PRCIS: Using optical coherence tomography measurements as a reference standard for vertical cup-to-disc ratio (vCDR), a smartphone-based ophthalmic camera has a sensitivity of 67.7% and specificity of 96.7% to detect a vCDR greater tha

Auteurs: Idriss BR Tran TM Atwine D Chang RT Myung D Onyango J
Référence de l'article: Journal of glaucoma 2020 Dec 29; Publish Ahead of Print(); Array. doi: 10.1097/IJG.0000000000001779. Epub 2020 12 29

Feasibility of satellite image and GIS sampling for population representative surveys: a case study from rural Guatemala.


BACKGROUND: Population-representative household survey methods require up-to-date sampling frames and sample designs that minimize time and cost of fieldwork especially in low- and middle-income countries.

Auteurs: Miller AC Rohloff P Blake A Dhaenens E Shaw L Tuiz E Grandesso F Mendoza Montano C Thomson DR
Référence de l'article: International journal of health geographics 2020 Dec 05; 19(1); 56. doi: 10.1186/s12942-020-00250-0. Epub 2020 12 05
Guatemala Population-representative study Sample selection Sampling frame Simple random sample

Successive epidemic waves of cholera in South Sudan between 2014 and 2017: a descriptive epidemiological study.


BACKGROUND: Between 2014 and 2017, successive cholera epidemics occurred in South Sudan within the context of civil war, population displacement, flooding, and drought.

Auteurs: Jones FK Wamala JF Rumunu J Mawien PN Kol MT Wohl S Deng L Pezzoli L Omar LH Lessler J Quilici ML Luquero FJ Azman AS
Référence de l'article: The Lancet. Planetary health 2020 Dec ; 4(12); e577-e587. doi: 10.1016/S2542-5196(20)30255-2. Epub 2020 12 24

A telephone based assessment of the health situation in the far north region of Cameroon.


BACKGROUND: In 2017, Field access was considerably limited in the Far North region of Cameroon due to the conflict.

Auteurs: Gignoux EMH Donfack Sontsa OT Mudasiru A Eyong J Ntone R Tamakloe Koku M Adji DM Etoundi A Boum Y Jamet C Cabrol JC Porten K
Référence de l'article: Conflict and health 2020 Nov 30; 14(1); 82. doi: 10.1186/s13031-020-00327-4. Epub 2020 11 30
Conflict Healthcare Mortality Telephone

Evaluating Ten Commercially-Available SARS-CoV-2 Rapid Serological Tests Using the STARD (Standards for Reporting of Diagnostic Accuracy Studies) Method.


Numerous SARS-CoV-2 rapid serological tests have been developed, but their accuracy has usually been assessed using very few samples, and rigorous comparisons between these tests are scarce.

Auteurs: Dortet L Ronat JB Vauloup-Fellous C Langendorf C Mendels DA Emeraud C Oueslati S Girlich D Chauvin A Afdjei A Bernabeu S Le Pape S Kallala R Rochard A Verstuyft C Fortineau N Roque-Afonso AM Naas T
Référence de l'article: Journal of clinical microbiology 2020 Nov 25; (); Array. doi: 10.1128/JCM.02342-20. Epub 2020 11 25

MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era.


BACKGROUND: Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays due to the RpoB I491F resistance mutation are threatening the control of MD

Auteurs: Beckert P Sanchez-Padilla E Merker M Dreyer V Kohl TA Utpatel C Köser CU Barilar I Ismail N Omar SV Klopper M Warren RM Hoffmann H Maphalala G Ardizzoni E de Jong BC Kerschberger B Schramm B Andres S Kranzer K Maurer FP Bonnet M Niemann S
Référence de l'article: Genome medicine 2020 Nov 25; 12(1); 104. doi: 10.1186/s13073-020-00793-8. Epub 2020 11 25
Diagnostice escape MDR outbreak strains Multidrug resistance Resistance evolution Treatment escape Treatment failure Tuberculosis

Dengue in Western Uganda: a prospective cohort of children presenting with undifferentiated febrile illness.


BACKGROUND: The spatial distribution and burden of dengue in sub-Saharan Africa remains highly uncertain, despite high levels of ecological suitability.

Auteurs: Boyce RM Collins M Muhindo R Nakakande R Ciccone EJ Grounds S Espinoza D Zhu Y Matte M Ntaro M Nyehangane D Juliano JJ Mulogo EM
Référence de l'article: BMC infectious diseases 2020 Nov 11; 20(1); 835. doi: 10.1186/s12879-020-05568-5. Epub 2020 11 11
Arbovirus Dengue Epidemiology Fever Uganda