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ENG

Severe acute malnutrition results in lower lumefantrine exposure in children treated with artemether-lumefantrine for uncomplicated malaria.

Abstract

Severe acute malnutrition (SAM) has been reported to be associated with increased malaria morbidity in Sub-Saharan African children and may affect the pharmacology of antimalarial drugs.

Auteurs: Chotsiri P Denoeud-Ndam L Baudin E Guindo O Diawara H Attaher O Smit M Guerin PJ Doumbo OK Wiesner L Barnes KI Hoglund RM Dicko A Etard JF Tarning J
Référence de l'article: Clinical pharmacology and therapeutics 2019 Jun 01; (); Array. doi: 10.1002/cpt.1531. Epub 2019 06 01
Lumefantrine malaria malnutrition non-linear mixed effects modelling population pharmacokinetic-pharmacodynamic model severe acute malnutrition children
ENG

Molecular epidemiology of hepatitis C virus in Cambodia during 2016-2017.

Abstract

In Cambodia, little epidemiological data of hepatitis C virus (HCV) is available. All previous studies were limited to only small or specific populations.

Auteurs: Nouhin J Iwamoto M Prak S Dousset JP Phon K Heng S Kerleguer A Le Paih M Dussart P Maman D Rouet F
Référence de l'article: Scientific reports 2019 May 13; 9(1); 7314. doi: 10.1038/s41598-019-43785-4. Epub 2019 05 13
ENG

Outcomes of Bedaquiline Treatment in Patients with Multidrug-Resistant Tuberculosis.

Abstract

Bedaquiline is recommended by the World Health Organization for the treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB).

Auteurs: Mbuagbaw L Guglielmetti L Hewison C Bakare N Bastard M Caumes E Fréchet-Jachym M Robert J Veziris N Khachatryan N Kotrikadze T Hayrapetyan A Avaliani Z Schünemann HJ Lienhardt C
Référence de l'article: Emerging infectious diseases 2019 May ; 25(5); 936-943. doi: 10.3201/eid2505.181823. Epub 2019 04 19
Armenia Asia China Europe France Georgia MDR South Africa TB XDR antimicrobial resistance bacteria bedaquiline extensively drug resistant individual patient data multidrug resistant tuberculosis tuberculosis and other mycobacteria
ENG

Plaidoyer contre l'exclusion des francophones dans la recherche en santé mondiale

Abstract

La tenue de l'Africa Health Agenda International Conference (AHAIC) à Kigali (Rwanda) début mars 2019 a été l'occasion d'organiser un atelier de discussion en français qui a permis de recueillir les témoignages de participants francophones sur l'impact

Auteurs: Roca A Boum Y Wachsmuth I
Référence de l'article: The Lancet Global Health
Francophone Research Scientists Publishing Africa Health Agenda International Conference (AHAIC)
ENG

A screening tool for psychological difficulties in children aged 6 to 36 months: cross-cultural validation in Kenya, Cambodia and Uganda.

Abstract

BACKGROUND: In low-resource settings, the lack of mental health professionals and cross-culturally validated screening instruments complicates mental health care delivery. This is especially the case for very young children.

Auteurs: Nackers F Roederer T Marquer C Ashaba S Maling S Mwanga-Amumpaire J Muny S Sokeo C Shom V Palha M Lefèbvre P Kirubi BW Kamidigo G Falissard B Moro MR Grais RF
Référence de l'article: BMC pediatrics 2019 Apr 12; 19(1); 108. doi: 10.1186/s12887-019-1461-3. Epub 2019 04 12
Cambodia Kenya Low-income population Mental health Preschool children Psychology Screening Uganda Validation
ENG

High incidence of intended partner pregnancy among men living with HIV in rural Uganda: Implications for safer conception services.

Abstract

BACKGROUND: Many men with HIV express fertility intentions and nearly half have HIV-uninfected sexual partners. We measured partner pregnancy among a cohort of men accessing antiretroviral therapy (ART) in Uganda.

Auteurs: Kaida A Kabakyenga J Bwana M Bajunirwe F Muyindike W Bennett K Kembabazi A Haberer JE Boum Y Martin JN Hunt PW Bangsberg DR Matthews LT
Référence de l'article: Journal of acquired immune deficiency syndromes (1999) 2019 Apr 08; (); Array. doi: 10.1097/QAI.0000000000002053. Epub 2019 04 08
ENG

Diagnostic value of the urine lipoarabinomannan assay in HIV-positive, ambulatory patients with CD4 below 200 cells/μl in 2 low-resource settings: A prospective observational study.

Abstract

BACKGROUND: Current guidelines recommend the use of the lateral flow urine lipoarabinomannan assay (LAM) in HIV-positive, ambulatory patients with signs and symptoms of tuberculosis (TB) only if they are seriously ill or have CD4 count

Auteurs: Huerga H Mathabire Rucker SC Cossa L Bastard M Amoros I Manhiça I Mbendera K Telnov A Szumilin E Sanchez-Padilla E Molfino L
Référence de l'article: PLoS medicine 2019 Apr ; 16(4); e1002792. doi: 10.1371/journal.pmed.1002792. Epub 2019 04 30
ENG

Risk score for predicting mortality including urine lipoarabinomannan detection in hospital inpatients with HIV-associated tuberculosis in sub-Saharan Africa: Derivation and external validation cohort study.

Abstract

BACKGROUND: The prevalence of and mortality from HIV-associated tuberculosis (HIV/TB) in hospital inpatients in Africa remains unacceptably high.

Auteurs: Gupta-Wright A Corbett EL Wilson D van Oosterhout JJ Dheda K Huerga H Peter J Bonnet M Alufandika-Moyo M Grint D Lawn SD Fielding K
Référence de l'article: PLoS medicine 2019 Apr ; 16(4); e1002776. doi: 10.1371/journal.pmed.1002776. Epub 2019 04 05
ENG

Linear growth faltering and the role of weight attainment: Prospective analysis of young children recovering from severe wasting in Niger.

Abstract

Efforts to reduce the impact of stunting have been largely independent of interventions to reduce the impact of wasting, despite the observation that the conditions can coexist in the same child and increase risk of death.

Auteurs: Isanaka S Hitchings MDT Berthé F Briend A Grais RF
Référence de l'article: Maternal & child nutrition 2019 Mar 23; (); e12817. doi: 10.1111/mcn.12817. Epub 2019 03 23
Niger child malnutrition linear growth stunting wasting weight gain
ENG

Further evidence of Mycobacterium tuberculosis in the sputum of culture-negative pulmonary tuberculosis suspects using an ultrasensitive molecular assay.

Abstract

BACKGROUND: Rapid diagnosis of pulmonary tuberculosis (TB) is critical to TB control. However, many patients with paucibacillary TB disease remain undiagnosed. Current TB elimination goals require new tools to diagnose early disease.

Auteurs: Madico G Vinhas S Orr B White L Gaeddert M Miller NS Mpeirwe M Orikiriza P Mwanga-Amumpaire J Boum Y Palaci M Dietze R Jones-López EC
Référence de l'article: Tuberculosis (Edinburgh, Scotland) 2019 Mar 23; 116(); 1-7. doi: 10.1016/j.tube.2019.03.007. Epub 2019 03 23
Culture-negative disease Diagnosis Genotyping Mycobacterium tuberculosis Paucibacillary disease