Publications

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Clinical utility of the FilmArray® meningitis/encephalitis panel in children with suspected central nervous system infection in a low-resource setting - a prospective study in Southwestern Uganda.

Abstract

BACKGROUND: In low-resource settings, limited laboratory capacity adds to the burden of central nervous system (CNS) infections in children and spurs overuse of antibiotics.

Rasti R Kumbakumba E Nanjebe D Mlotshwa P Nassejje M Mzee J Businge S Akankwasa G Nyehangane D Gantelius J Boum Y Mårtensson A Mwanga-Amumpaire J Alfvén T Gaudenzi G
BMC infectious diseases 2025 Mar 22; 25(1); . doi: 10.1186/s12879-025-10732-w. Epub 2025 03 22
Central nervous system infections FilmArray Global health Meningitis Molecular diagnostic techniques Paediatrics

Initial evaluation of a new cervical screening strategy combining human papillomavirus genotyping and automated visual evaluation: the Human Papillomavirus-Automated Visual Evaluation Consortium.

Abstract

The HPV-Automated Visual Evaluation (PAVE) Consortium is validating a cervical screening strategy enabling accurate cervical screening in resource-limited settings.

Befano B Kalpathy-Cramer J Egemen D Inturrisi F Jeronimo J Rodríguez AC Campos N Cremer M Ribeiro A Ajenifuja KO Goldstein A Haider A Yeates K Madeleine M Norris T Figueroa J Alfaro K Raiol T Adepiti C Norman J Chilinda GK Mchome B Donastorg Y Dlamini X Conzuelo G Banjo AA Chone P Mremi A Benitez A Rosberger Z Vantha T Prieto-Egido I Boyd-Morin J Clark C Kinder S Wentzensen N Desai K Perkins R de Sanjosé S Schiffman M
Journal of the National Cancer Institute 2025 Mar 18; . doi: 10.1093/jnci/djaf054. Epub 2025 03 18

Understanding the medical challenges for the diagnosis and treatment of bilateral pitting oedema in children: a qualitative study.

Abstract

Severely malnourished patients can present with bilateral pitting oedema, which is a common sign of Kwashiorkor. However, bilateral pitting oedema can also be an expression of other pathologies.

Scarpa G Sagara J Mambula C Koudika MH Loddo F Yonally-Phillips E Shamseldin M Tiv MH Lynch E Nimbu N Lulebo Mampasi A Mvuama Mazangama N Ag Iknane A Ben-Farhat J
PLOS global public health 2025 ; 5(3); . doi: 10.1371/journal.pgph.0004125. Epub 2025 03 18

High confidence and demand for hepatitis E vaccine during an outbreak in Bentiu, South Sudan: A qualitative study.

Abstract

In 2021 in response to an outbreak of hepatitis E in Bentiu internally displaced persons camp the South Sudanese Ministry of Health with support from Médecins Sans Frontières implemented the first-ever mass reactive vaccination campaign with HEV239 (He

Koyuncu A Asilaza KV Rumunu J Wamala J Gitahi P Antier Z Duncker J Nkemenang P Gakima P Haile M Gignoux E Albela M Loro FB Biem D Rull M Azman AS Ciglenecki I Nesbitt R
PLOS global public health 2025 ; 5(3); . doi: 10.1371/journal.pgph.0003482. Epub 2025 03 06

Low-Dose Yellow Fever Vaccine in Adults in Africa.

Abstract

BACKGROUND: Yellow fever vaccine is highly effective with a single dose, but vaccine supply is limited. The minimum dose requirements for seroconversion remain unknown.

Kimathi D Juan-Giner A Bob NS Orindi B Namulwana ML Diatta A Cheruiyot S Fall G Dia M Hamaluba MM Nyehangane D Karanja HK Gitonga JN Mugo D Omuoyo DO Hussein M Oloo E Kamau N Wafula J Bendera J Silvester N Mwavita J Joshua M Mwendwa J Agababyona C Ngetsa C Aisha N Moki F Buluku T Munene M Mwanga-Amumpaire J Lutwama J Kayiwa J Kamaara E Barrett AD Kaleebu P Bejon P Sall AA Grais RF Warimwe GM
The New England journal of medicine 2025 Feb 20; 392(8); . doi: 10.1056/NEJMoa2407293. Epub 2025 02 19

Impact of a multi-pronged cholera intervention in an endemic setting.

Abstract

Cholera is a bacterial water-borne diarrheal disease transmitted via the fecal-oral route that causes high morbidity in sub-Saharan Africa and Asia. It is preventable with vaccination, and Water, Sanitation, and Hygiene (WASH) improvements.

Blake A Walder A Hanks EM Welo PO Luquero F Bompangue D Bharti N
PLoS neglected tropical diseases 2025 Feb ; 19(2); . doi: 10.1371/journal.pntd.0012867. Epub 2025 02 19

Safety of 3-month rifampicin-isoniazid TPT in child household contacts in a community-based intervention.

Abstract

BACKGROUNDThe WHO recommends shorter TB preventive treatment (TPT) regimens and decentralised delivery models to improve effectiveness.

Tchakounte Youngui B Tchounga BK Atwine D Vasiliu A Cuer B Simo L Okello R Tchendjou P Kuate Kuate A Turyahabwe S Cohn J Graham SM Casenghi M Bonnet M
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2025 Feb 01; 29(2); . doi: 10.5588/ijtld.24.0311. Epub 2025 02 01