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Protection, health seeking, or a laissez-passer: Participants' decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo.

Abstract

During the 10th Ebola virus disease (EVD) epidemic in the eastern Democratic Republic of the Congo (DRC) (2018-2020), two experimental EVD vaccines were deployed in North Kivu.

James M Kasereka JG Kasiwa B Kavunga-Membo H Kambale K Grais R Muyembe-Tamfum JJ Bausch DG Watson-Jones D Lees S
Social science & medicine (1982) 2023 Mar 15; 323; . doi: 10.1016/j.socscimed.2023.115833. Epub 2023 03 15
Clinical trials DRC Ebola Epidemics Vaccine

Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis.

Abstract

BACKGROUND: Many children with pulmonary tuberculosis remain undiagnosed and untreated with related high morbidity and mortality.

Gunasekera KS Marcy O Muñoz J Lopez-Varela E Sekadde MP Franke MF Bonnet M Ahmed S Amanullah F Anwar A Augusto O Aurilio RB Banu S Batool I Brands A Cain KP Carratalá-Castro L Caws M Click ES Cranmer LM García-Basteiro AL Hesseling AC Huynh J Kabir S Lecca L Mandalakas A Mavhunga F Myint AA Myo K Nampijja D Nicol MP Orikiriza P Palmer M Sant'Anna CC Siddiqui SA Smith JP Song R Thuong Thuong NT Ung V van der Zalm MM Verkuijl S Viney K Walters EG Warren JL Zar HJ Marais BJ Graham SM Debray TPA Cohen T Seddon JA
The Lancet. Child & adolescent health 2023 Mar 13; . doi: 10.1016/S2352-4642(23)00004-4. Epub 2023 03 13

Evaluation of a Paediatric Early Warning System (PEWS) score on admission to a paediatric intensive care unit to predict mortality risk in a low resource setting, Guinea-Bissau

Abstract

CONTEXT: The Paediatric Early Warning System (PEWS) is a clinical monitoring tool used routinely in emergency and observation rooms to detect rapid deterioration in paediatric patients, allowing timely action.

Temessadouno F W Hiffler L Gallo J Gignoux E Domenichini C Janet S et al.
J Community Med Public Health Care 2023, 10: 125. doi: 10.24966/CMPH-1978/100012
Low resources setting PEWS PICU

High performance of systematic combined urine LAM test and sputum Xpert MTB/RIF® for tuberculosis screening in severely immunosuppressed ambulatory adults with HIV.

Abstract

BACKGROUND: In people with HIV (PWH), the WHO-recommended tuberculosis four-symptom screen (W4SS) targeting those who need molecular rapid test may be suboptimal.

Bonnet M Gabillard D Domoua S Muzoora C Messou E Sovannarith S Nguyen DB Badje A Juchet S Bunnet D Borand L Natukunda N Tran TH Anglaret X Laureillard D Blanc FX
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2023 Mar 08; . doi: 10.1093/cid/ciad125. Epub 2023 03 08
HIV diagnosis screening tuberculosis

High severity of abortion complications in fragile and conflict-affected settings: a cross-sectional study in two referral hospitals in sub-Saharan Africa (AMoCo study).

Abstract

BACKGROUND: Abortion-related complications are one of the five main causes of maternal mortality. However, research about abortion is very limited in fragile and conflict-affected settings.

Pasquier E Owolabi OO Fetters T Ngbale RN Adame Gbanzi MC Williams T Chen H Fotheringham C Lagrou D Schulte-Hillen C Powell B Baudin E Filippi V Benova L
BMC pregnancy and childbirth 2023 Mar 04; 23(1); . doi: 10.1186/s12884-023-05427-6. Epub 2023 03 04
Abortion Armed conflict Central African Republic Fragile Hospital Humanitarian Maternal health Nigeria Postabortion care

Implementation of targeted cholera response activities, Cameroon.

Abstract

OBJECTIVE: To describe the implementation of case-area targeted interventions to reduce cholera transmission using a rapid, localized response in Kribi district, Cameroon.

Jean Patrick Ouamba Nicole Fouda Mbarga Iza Ciglenecki Ruwan Ratnayake Dora Tchiasso Flavio Finger et al.
Bull World Health Organ v.101(3); 2023 Mar 1.online 2023 Jan 18. doi: 10.2471/BLT.22.288885
cholera

Effectiveness of Bedaquiline Use Beyond Six Months in Patients with Multidrug-Resistant Tuberculosis.

Abstract

RATIONALE: Current recommendations for the treatment of rifampin- and multidrug-resistant tuberculosis include bedaquiline used for six months or longer. Evidence is needed to inform the optimal duration of bedaquiline.

Trevisi L Hernán MA Mitnick CD Khan U Seung KJ Rich ML Bastard M Huerga H Melikyan N Atwood S Avaliani Z Llanos F Manzur-Ul-Alam M Zarli K Binedgie AB Adnan S Melikyan A Gelin A Isani AK Vetushko D Daugarina Z Nkundanyirazo P Putri FA Vilbrun C Khan M Hewison C Khan PY Franke MF
American journal of respiratory and critical care medicine 2023 Feb 21; . doi: 10.1164/rccm.202211-2125OC. Epub 2023 02 21
duration endTB observational study inverse probability weighting rifampicin-resistant tuberculosis target trial

Estimating COVID-19 vaccine uptake and its drivers among migrants, homeless and precariously housed people in France.

Abstract

BACKGROUND: Migrants, people experiencing homelessness (PEH), or precariously housed (PH) are at high risk for COVID-19 infection, hospitalization, and death from COVID-19.

Roederer T Mollo B Vincent C Leduc G Sayyad-Hilario J Mosnier M Vandentorren S
Communications medicine 2023 Feb 20; 3(1); . doi: 10.1038/s43856-023-00257-1. Epub 2023 02 20
covid-19 vaccine migrants France

Effect of large-scale mass drug administration for malaria on mortality and morbidity in Angumu health zone, Ituri, Democratic Republic of Congo.

Abstract

BACKGROUND: Angumu health zone in Ituri, Democratic Republic of Congo, is a highly malaria-endemic area with an overburdened health system and hosting internally displaced persons (IDP).

Grout L Katuala Givo Y Newport T Mahamat TA Gitahi P Mandagot JJ Quere M Wodon S Ciglenecki I Bastard M Baelongandi F Tshulo L Uluba HJ Sterk E Gignoux E
Malaria journal 2023 Feb 06; 22(1); . doi: 10.1186/s12936-023-04469-7. Epub 2023 02 06
Democratic Republic of Congo Malaria Mass drug administration (MDA) Mortality Prevention

Anthropometric criteria for best identifying children at high risk of mortality: a pooled analysis of 12 cohorts.

Abstract

OBJECTIVE: To understand which anthropometric diagnostic criteria best discriminate higher from lower risk of death in children and explore programme implications.

Khara T Myatt M Sadler K Bahwere P Berkley JA Black RE Boyd E Garenne M Isanaka S Lelijveld N McDonald C Mertens A Mwangome M O'Brien K Stobaugh H Taneja S West KP Briend A
Public health nutrition 2023 Feb 03; . doi: 10.1017/S136898002300023X. Epub 2023 02 03
Anthropometry Child survival Mid-upper arm circumference Mortality Therapeutic feeding Underweight Wasting, Stunting