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Treatment outcomes and tolerability of the revised WHO anti-tuberculosis drug dosages for children.


BACKGROUND: In 2010, the World Health Organization (WHO) revised the paediatric dosages of anti-tuberculosis drugs, increasing rifampicin to 15 mg/kg, isoniazid to 10 mg/kg and pyrazinamide to 35 mg/kg.

Auteurs: Nansumba M Kumbakumba E Orikiriza P Bastard M Mwanga JA Boum Y de Beaudrap P Bonnet M
Référence de l'article: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2018 02 01; 22(2); 151-157. doi: 10.5588/ijtld.17.0535. Epub 2017 12 20

Effectiveness of biologic and non-biologic antirheumatic drugs on anaemia markers in 153,788 patients with rheumatoid arthritis: New evidence from real-world data.


BACKGROUND: To evaluate the impact of treatment with disease-modifying antirheumatic drugs (DMARDs), including IL-6 receptor inhibitor tocilizumab (TCZ), on anaemia markers in patients with rheumatoid arthritis.

Auteurs: Paul SK Montvida O Best JH Gale S Pethoe-Schramm A Sarsour K
Référence de l'article: Seminars in arthritis and rheumatism 2018 02 ; 47(4); 478-484. doi: 10.1016/j.semarthrit.2017.08.001. Epub 2017 08 03
Change in anaemia markers Comparison of biologic and non-biologic DMARDs IL-6 receptor inhibitor Real-world data Tocilizumab

Efficacy of artesunate-amodiaquine, dihydroartemisinin-piperaquine and artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Maradi, Niger.


BACKGROUND: Malaria endemic countries need to assess efficacy of anti-malarial treatments on a regular basis.

Auteurs: Grandesso F Guindo O Woi Messe L Makarimi R Traore A Dama S Laminou IM Rigal J de Smet M Ouwe Missi Oukem-Boyer O Doumbo OK Djimdé A Etard JF
Référence de l'article: Malaria journal 2018 Jan 25; 17(1); 52. doi: 10.1186/s12936-018-2200-1. Epub 2018 01 25
Antimalarial Artemisinin Efficacy Malaria Niger Parasite clearance Resistance

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa.


BACKGROUND: In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-6-phosphate

Auteurs: Taylor WR Naw HK Maitland K Williams TN Kapulu M D'Alessandro U Berkley JA Bejon P Okebe J Achan J Amambua AN Affara M Nwakanma D van Geertruyden JP Mavoko M Lutumba P Matangila J Brasseur P Piola P Randremanana R Lasry E Fanello C Onyamboko M Schramm B Yah Z Jones J Fairhurst RM Diakite M Malenga G Molyneux M Rwagacondo C Obonyo C Gadisa E Aseffa A Loolpapit M Henry MC Dorsey G John C Sirima SB Barnes KI Kremsner P Day NP White NJ Mukaka M
Référence de l'article: BMC medicine 2018 01 18; 16(1); 11. doi: 10.1186/s12916-017-0990-6. Epub 2018 01 18
Age-based dosing Malaria Plasmodium falciparum Primaquine Transmission blocking

High rates of hypertension, diabetes, elevated low-density lipoprotein cholesterol, and cardiovascular disease risk factors in HIV-infected patients in Malawi.


OBJECTIVES: Data on cardiovascular disease risks among HIV-infected patients taking antiretroviral therapy (ART) over long periods of time are lacking in Sub-Saharan Africa.

Auteurs: Mathabire Rücker SC Tayea A Bitilinyu-Bangoh J Bermúdez-Aza EH Salumu L Quiles IA Szumilin E Chirwa Z Rick F Maman D
Référence de l'article: AIDS (London, England) 2018 Jan 14; 32(2); 253-260. doi: 10.1097/QAD.0000000000001700. Epub 2018 07 16

Detection of Plasmodium Species by High-Resolution Melt Analysis of DNA from Blood Smears Acquired in Southwestern Uganda.


Microscopic diagnosis of malaria using Giemsa-stained blood smears is the standard of care in resource-limited settings.

Auteurs: Kassaza K Operario DJ Nyehangane D Coffey KC Namugosa M Turkheimer L Ojuka P Orikiriza P Mwanga-Amumpaire J Byarugaba F Bazira J Guler JL Moore CC Boum Y
Référence de l'article: Journal of clinical microbiology 2018 01 ; 56(1); Array. doi: 10.1128/JCM.01060-17. Epub 2017 12 26
PCR diagnostics high-resolution melting malaria

What's coming for health science and policy in 2018? Global experts look ahead in their field.


In PLOS Medicine's first editorial of 2018, editorial board members and other leading researchers share their hopes, pleas, concerns, and expectations for this year in health research and policy.

Auteurs: Swaminathan S Room RS Ivers LC Hillis G Grais RF Bhutta ZA Byass P
Référence de l'article: PLoS medicine 2018 01 ; 15(1); e1002498. doi: 10.1371/journal.pmed.1002498. Epub 2018 01 30

Dried Blood Spots for Measuring Vibrio cholerae-specific Immune Responses.


BACKGROUND: Vibrio cholerae causes over 2 million cases of cholera and 90,000 deaths each year.

Auteurs: Iyer AS Azman AS Bouhenia M Deng LO Anderson CP Graves M Kováč P Xu P Ryan ET Harris JB Sack DA Luquero FJ Leung DT
Référence de l'article: PLoS neglected tropical diseases 2018 01 ; 12(1); e0006196. doi: 10.1371/journal.pntd.0006196. Epub 2018 01 29

Unreported cases in the 2014-2016 Ebola epidemic: Spatiotemporal variation, and implications for estimating transmission.


In the recent 2014-2016 Ebola epidemic in West Africa, non-hospitalized cases were an important component of the chain of transmission.

Auteurs: Dalziel BD Lau MSY Tiffany A McClelland A Zelner J Bliss JR Grenfell BT
Référence de l'article: PLoS neglected tropical diseases 2018 01 ; 12(1); e0006161. doi: 10.1371/journal.pntd.0006161. Epub 2018 01 22