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Molecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger.


BACKGROUND: In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season.

Auteurs: Grais RF Laminou IM Woi-Messe L Makarimi R Bouriema SH Langendorf C Amambua-Ngwa A D'Alessandro U Guérin PJ Fandeur T Sibley CH
Référence de l'article: Malaria journal 2018 Feb 27; 17(1); 98. doi: 10.1186/s12936-018-2242-4. Epub 2018 02 27
Malaria Niger Prevention Seasonal malaria chemoprophylaxis
Auteurs: Ferreras E Chizema-Kawesha E Blake A Chewe O Mwaba J Zulu G Poncin M Rakesh A Page AL Stoitsova S Voute C Uzzeni F Robert H Serafini M Matapo B Eiros JM Quilici ML Pezzoli L Azman AS Cohuet S Ciglenecki I Malama K Luquero FJ
Référence de l'article: The New England journal of medicine 2018 02 08; 378(6); 577-579. doi: 10.1056/NEJMc1711583. Epub 2018 02 14

Outcome of Children With Presumptive Tuberculosis in Mbarara, Rural Uganda.


BACKGROUND: Mortality among children with presumptive tuberculosis (TB) empiric TB treatment can be high. We describe the predictors of death among children with presumptive TB, and the relation between treatment and mortality.

Auteurs: Bonnet M Nansumba M Bastard M Orikiriza P Kyomugasho N Nansera D Boum Y de Beaudrap P Kiwanuka J Kumbakumba E
Référence de l'article: The Pediatric infectious disease journal 2018 02 ; 37(2); 147-152. doi: 10.1097/INF.0000000000001727. Epub 2018 12 11

Improving rotavirus vaccine coverage: Can newer-generation and locally produced vaccines help?


There are two internationally available WHO-prequalified oral rotavirus vaccines (Rotarix and RotaTeq), two rotavirus vaccines licensed in India (Rotavac and Rotasiil), one in China (Lanzhou lamb rotavirus vaccine) and one in Vietnam (Rotavin-M1), and

Auteurs: Deen J Lopez AL Kanungo S Wang XY Anh DD Tapia M Grais RF
Référence de l'article: Human vaccines & immunotherapeutics 2018 02 01; 14(2); 495-499. doi: 10.1080/21645515.2017.1403705. Epub 2017 12 21
Rotavirus rotavirus vaccination rotavirus vaccine

Implementation research: reactive mass vaccination with single-dose oral cholera vaccine, Zambia.


Objective: To describe the implementation and feasibility of an innovative mass vaccination strategy - based on single-dose oral cholera vaccine - to curb a cholera epidemic in a large urban setting.

Auteurs: Poncin M Zulu G Voute C Ferreras E Muleya CM Malama K Pezzoli L Mufunda J Robert H Uzzeni F Luquero FJ Chizema E Ciglenecki I
Référence de l'article: Bulletin of the World Health Organization 2018 Feb 01; 96(2); 86-93. doi: 10.2471/BLT.16.189241. Epub 2017 10 19

Inequality in outcomes for adolescents living with perinatally acquired HIV in sub-Saharan Africa: a Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Cohort Collaboration analysis.


INTRODUCTION: Eighty percent of adolescents living with perinatally and behaviourally acquired HIV live in sub-Saharan Africa (SSA), a continent with marked economic inequality.

Référence de l'article: Journal of the International AIDS Society 2018 Feb ; 21 Suppl 1(); Array. doi: 10.1002/jia2.25044. Epub 2019 02 16

Sustainable Development Goals adolescent perinatally acquired sub-Saharan Africa

The potential impact of case-area targeted interventions in response to cholera outbreaks: A modeling study.


BACKGROUND: Cholera prevention and control interventions targeted to neighbors of cholera cases (case-area targeted interventions [CATIs]), including improved water, sanitation, and hygiene, oral cholera vaccine (OCV), and prophylactic

Auteurs: Finger F Bertuzzo E Luquero FJ Naibei N Touré B Allan M Porten K Lessler J Rinaldo A Azman AS
Référence de l'article: PLoS medicine 2018 02 ; 15(2); e1002509. doi: 10.1371/journal.pmed.1002509. Epub 2018 02 27

High Prevalence of or Enteroinvasive Carriage among Residents of an Internally Displaced Persons Camp in South Sudan.


Displaced persons living in camps are at an increased risk of diarrheal diseases. Subclinical carriage of pathogens may contribute to the spread of disease, especially for microbes that require a low infectious dose.

Auteurs: Bliss J Bouhenia M Hale P Couturier BA Iyer AS Rumunu J Martin S Wamala JF Abubakar A Sack DA Luquero FJ Couturier MR Azman AS Leung DT
Référence de l'article: The American journal of tropical medicine and hygiene 2018 02 ; 98(2); 595-597. doi: 10.4269/ajtmh.17-0339. Epub 2017 11 30

Treatment outcomes and tolerability of the revised WHO anti-tuberculosis drug dosages for children.


BACKGROUND: In 2010, the World Health Organization (WHO) revised the paediatric dosages of anti-tuberculosis drugs, increasing rifampicin to 15 mg/kg, isoniazid to 10 mg/kg and pyrazinamide to 35 mg/kg.

Auteurs: Nansumba M Kumbakumba E Orikiriza P Bastard M Mwanga JA Boum Y de Beaudrap P Bonnet M
Référence de l'article: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2018 02 01; 22(2); 151-157. doi: 10.5588/ijtld.17.0535. Epub 2017 12 20

Effectiveness of biologic and non-biologic antirheumatic drugs on anaemia markers in 153,788 patients with rheumatoid arthritis: New evidence from real-world data.


BACKGROUND: To evaluate the impact of treatment with disease-modifying antirheumatic drugs (DMARDs), including IL-6 receptor inhibitor tocilizumab (TCZ), on anaemia markers in patients with rheumatoid arthritis.

Auteurs: Paul SK Montvida O Best JH Gale S Pethoe-Schramm A Sarsour K
Référence de l'article: Seminars in arthritis and rheumatism 2018 02 ; 47(4); 478-484. doi: 10.1016/j.semarthrit.2017.08.001. Epub 2017 08 03
Change in anaemia markers Comparison of biologic and non-biologic DMARDs IL-6 receptor inhibitor Real-world data Tocilizumab