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Brief Report: Higher ART Adherence Is Associated With Lower Systemic Inflammation in Treatment-Naive Ugandans Who Achieve Virologic Suppression.


BACKGROUND: Residual systemic inflammation persists despite suppressive antiretroviral therapy (ART) and is associated with non-AIDS clinical outcomes.

Auteurs: Castillo-Mancilla JR Morrow M Boum Y Byakwaga H Haberer JE Martin JN Bangsberg D Mawhinney S Musinguzi N Huang Y Tracy RP Burdo TH Williams K Muzzora C Hunt PW Siedner MJ
Référence de l'article: Journal of acquired immune deficiency syndromes (1999) 2018 Apr 15; 77(5); 507-513. doi: 10.1097/QAI.0000000000001629. Epub 2018 11 13

Characteristics of human encounters and social mixing patterns relevant to infectious diseases spread by close contact: a survey in Southwest Uganda.


BACKGROUND: Quantification of human interactions relevant to infectious disease transmission through social contact is central to predict disease dynamics, yet data from low-resource settings remain scarce.

Auteurs: le Polain de Waroux O Cohuet S Ndazima D Kucharski AJ Juan-Giner A Flasche S Tumwesigye E Arinaitwe R Mwanga-Amumpaire J Boum Y Nackers F Checchi F Grais RF Edmunds WJ
Référence de l'article: BMC infectious diseases 2018 04 11; 18(1); 172. doi: 10.1186/s12879-018-3073-1. Epub 2018 04 11
Close contact transmission Infectious diseases Social contact Survey Uganda
Auteurs: Godreuil S Marcy O Wobudeya E Bonnet M Solassol J
Référence de l'article: The Lancet. Public health 2018 04 ; 3(4); e165. doi: 10.1016/S2468-2667(18)30049-5. Epub 2018 03 24

Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis.


BACKGROUND: Isoniazid-resistant, rifampicin-susceptible (INH-R) tuberculosis is the most common form of drug resistance, and is associated with failure, relapse, and acquired rifampicin resistance if treated with first-line anti-tuberc

Auteurs: Fregonese F Ahuja SD Akkerman OW Arakaki-Sanchez D Ayakaka I Baghaei P Bang D Bastos M Benedetti A Bonnet M Cattamanchi A Cegielski P Chien JY Cox H Dedicoat M Erkens C Escalante P Falzon D Garcia-Prats AJ Gegia M Gillespie SH Glynn JR Goldberg S Griffith D Jacobson KR Johnston JC Jones-López EC Khan A Koh WJ Kritski A Lan ZY Lee JH Li PZ Maciel EL Galliez RM Merle CSC Munang M Narendran G Nguyen VN Nunn A Ohkado A Park JS Phillips PPJ Ponnuraja C Reves R Romanowski K Seung K Schaaf HS Skrahina A Soolingen DV Tabarsi P Trajman A Trieu L Banurekha VV Viiklepp P Wang JY Yoshiyama T Menzies D
Référence de l'article: The Lancet. Respiratory medicine 2018 04 ; 6(4); 265-275. doi: 10.1016/S2213-2600(18)30078-X. Epub 2018 10 19

Syrian refugees in Greece: experience with violence, mental health status, and access to information during the journey and while in Greece.


BACKGROUND: Since 2015, Europe has been facing an unprecedented arrival of refugees and migrants: more than one million people entered via land and sea routes.

Auteurs: Ben Farhat J Blanchet K Juul Bjertrup P Veizis A Perrin C Coulborn RM Mayaud P Cohuet S
Référence de l'article: BMC medicine 2018 03 13; 16(1); 40. doi: 10.1186/s12916-018-1028-4. Epub 2018 03 13
Access Europe Greece Journey Mental health Migrants Refugees Syria Violence

High Proportions of Patients With Advanced HIV Are Antiretroviral Therapy Experienced: Hospitalization Outcomes From 2 Sub-Saharan African Sites.


Background: Human immunodeficiency virus (HIV) remains an important cause of hospitalization and death in low- and middle- income countries.

Auteurs: Ousley J Niyibizi AA Wanjala S Vandenbulcke A Kirubi B Omwoyo W Price J Salumu L Szumilin E Spiers S van Cutsem G Mashako M Mangana F Moudarichirou R Harrison R Kalwangila T Lumowo G Lambert V Maman D
Référence de l'article: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018 Mar 04; 66(suppl_2); S126-S131. doi: 10.1093/cid/ciy103. Epub 2018 11 14

Progress towards the UNAIDS 90-90-90 goals by age and gender in a rural area of KwaZulu-Natal, South Africa: a household-based community cross-sectional survey.


BACKGROUND: The Joint United Nations Programme on HIV/AIDS (UNAIDS) has developed an ambitious strategy to end the AIDS epidemic.

Auteurs: Huerga H Van Cutsem G Ben Farhat J Puren A Bouhenia M Wiesner L Dlamini L Maman D Ellman T Etard JF
Référence de l'article: BMC public health 2018 03 02; 18(1); 303. doi: 10.1186/s12889-018-5208-0. Epub 2018 03 02
Africa Cascade of care HIV UNAIDS targets Viral load

The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis.


BACKGROUND: Globally, the population of adolescents living with perinatally acquired HIV (APHs) continues to expand.

Auteurs: Slogrove AL Schomaker M Davies MA Williams P Balkan S Ben-Farhat J Calles N Chokephaibulkit K Duff C Eboua TF Kekitiinwa-Rukyalekere A Maxwell N Pinto J Seage G Teasdale CA Wanless S Warszawski J Wools-Kaloustian K Yotebieng M Timmerman V Collins IJ Goodall R Smith C Patel K Paul M Gibb D Vreeman R Abrams EJ Hazra R Van Dyke R Bekker LG Mofenson L Vicari M Essajee S Penazzato M Anabwani G Q Mohapi E N Kazembe P Hlatshwayo M Lumumba M Goetghebuer T Thorne C Galli L van Rossum A Giaquinto C Marczynska M Marques L Prata F Ene L Okhonskaia L Rojo P Fortuny C Naver L Rudin C Le Coeur S Volokha A Rouzier V Succi R Sohn A Kariminia A Edmonds A Lelo P Ayaya S Ongwen P Jefferys LF Phiri S Mubiana-Mbewe M Sawry S Renner L Sylla M Abzug MJ Levin M Oleske J Chernoff M Traite S Purswani M Chadwick EG Judd A Leroy V
Référence de l'article: PLoS medicine 2018 03 ; 15(3); e1002514. doi: 10.1371/journal.pmed.1002514. Epub 2018 03 01

Molecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger.


BACKGROUND: In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season.

Auteurs: Grais RF Laminou IM Woi-Messe L Makarimi R Bouriema SH Langendorf C Amambua-Ngwa A D'Alessandro U Guérin PJ Fandeur T Sibley CH
Référence de l'article: Malaria journal 2018 Feb 27; 17(1); 98. doi: 10.1186/s12936-018-2242-4. Epub 2018 02 27
Malaria Niger Prevention Seasonal malaria chemoprophylaxis