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Investigating the link between Alpha-1 Antitrypsin Deficiency and Abdominal Aortic Aneurysms.


OBJECTIVES: Alpha-1-Antitrypsin (AAT) is one of the major plasmatic protease inhibitors. In the last decade, an association between Alpha-1-Antitrypsin Deficiency (AATD) and Abdominal Aortic Aneurysms (AAA) has been hypothesized.

Pini L Peroni M Zanotti C Pini A Bossoni E Giordani J Bargagli E Perger E Ferrarotti I Vizzardi E Tiberio L Bonardelli S Tantucci C
Annals of vascular surgery 2021 Aug 26; doi: 10.1016/j.avsg.2021.05.064. Epub 2021 08 26
Abdominal Aortic Aneurysm Allelic Variants Alpha-1 Antitrypsin Deficiency Genotyping Vascular Disease

Development of a dosing-adjustment tool for fluoroquinolones in osteoarticular infections: The Fluo-pop study.


Fluoroquinolones efficacy depend on both the drug exposure and the level of drug resistance of the bacteria responsible for the infection.

Lemaitre F Fily F Foulquier JB Revest M Jullien V Petitcollin A Tattevin P Tron C Polard JL Verdier MC Comets E Huten D Arvieux C Bellissant E Laviolle B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug 19; 142 112053. doi: 10.1016/j.biopha.2021.112053. Epub 2021 08 19
Bone infection Joint infection Modeling Ofloxacin Pharmacokinetics

A feasibility study using mid-upper arm circumference as the sole anthropometric criterion for admission and discharge in the outpatient treatment for severe acute malnutrition.


BACKGROUND: The World Health Organization recommends the use of a weight-for-height Z-score (WHZ) and/or mid-upper arm circumference (MUAC) as anthropometric criteria for the admission and discharge of young children for the community-

Garba S Salou H Nackers F Ayouba A Escruela M Guindo O Rocaspana M Grais RF Isanaka S
BMC nutrition 2021 Aug 12; 7(1); 47. doi: 10.1186/s40795-021-00448-w. Epub 2021 08 12
Admission criteria Community-based management of acute malnutrition Discharge criteria Mid-upper arm circumference Niger Severe acute malnutrition Wasting

The HIV cascade of care among serodiscordant couples in four high HIV prevalence settings in sub-Saharan Africa.


BACKGROUND:  HIV-serodiscordant couples are at high risk of HIV transmission. In sub-Saharan Africa, HIV-serodiscordant couples contribute ~30% of all new infections in the region.

Chihana ML Conan N Ellman T Poulet E Garone DB Ortuno R Wanjala S Masiku C Etard JF Davies MA Maman D
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2021 Aug 02; 111(8); . doi: 10.7196/SAMJ.2021.v111i8.15489. Epub 2021 08 02

How to improve outbreak response: a case study of integrated outbreak analytics from Ebola in Eastern Democratic Republic of the Congo.


The emerging field of outbreak analytics calls attention to the need for data from multiple sources to inform evidence-based decision making in managing infectious diseases outbreaks.

Carter SE Ahuka-Mundeke S Pfaffmann Zambruni J Navarro Colorado C van Kleef E Lissouba P Meakin S le Polain de Waroux O Jombart T Mossoko M Bulemfu Nkakirande D Esmail M Earle-Richardson G Degail MA Umutoni C Anoko JN Gobat N
BMJ global health 2021 Aug ; 6(8); doi: 10.1136/bmjgh-2021-006736. Epub 2021 08 20
epidemiology health services research other study design public health viral haemorrhagic fevers

Performance of six rapid diagnostic tests for SARS-CoV-2 antigen detection and implications for practical use.


BACKGROUND: Direct detection of SARS-CoV-2 viral proteins in nasopharyngeal swabs using lateral flow immunoassays is a simple, fast and cheap approach to diagnose the infection.

Fourati S Langendorf C Audureau E Challine D Michel J Soulier A Ahnou N Désveaux I Picard O Ortonne V Gourgeon A Mills C Hémery F Rieux C Pawlotsky JM Malou N Chevaliez S
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2021 Jul 25; 142 104930. doi: 10.1016/j.jcv.2021.104930. Epub 2021 07 25
Antigen assay COVID-19 Diagnostic Rapid diagnostic test SARS-CoV-2 Screening