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Surveillance of Plasmodium falciparum pfcrt haplotypes in southwestern uganda by high-resolution melt analysis.


BACKGROUND: Chloroquine (CQ) resistance is conferred by mutations in the Plasmodium falciparum CQ resistance transporter (pfcrt).

Kassaza K Long AC McDaniels JM Andre M Fredrickson W Nyehangane D Orikiriza P Operario DJ Bazira J Mwanga-Amumpaire JA Moore CC Guler JL Boum Y
Malaria journal 2021 Feb 25; 20(1); 114. doi: 10.1186/s12936-021-03657-7. Epub 2021 02 25
Chloroquine HRM Plasmodium falciparum Resistance Uganda pfcrt

Emergency department admission and hospitalization for COPD exacerbation and particulate matter short-term exposure in Brescia, a highly polluted town in northern Italy.


BACKGROUND: Short-term exposure to high Particulate Matter (PM) concentrations worsens several respiratory conditions.

Pini L Giordani J Gardini G Concoreggi C Pini A Perger E Vizzardi E Di Bona D Cappelli C Ciarfaglia M Tantucci C
Respiratory medicine 2021 Feb 16; 179 106334. doi: 10.1016/j.rmed.2021.106334. Epub 2021 02 16

Novel transdisciplinary methodology for cross-sectional analysis of snakebite epidemiology at national scale.


BACKGROUND: Worldwide, it is estimated that snakes bite 4.5-5.4 million people annually, 2.7 million of which are envenomed, and 81,000-138,000 die.

Alcoba G Ochoa C Babo Martins S Ruiz de Castañeda R Bolon I Wanda F Comte E Subedi M Shah B Ghimire A Gignoux E Luquero F Nkwescheu AS Sharma SK Chappuis F Ray N
PLoS neglected tropical diseases 2021 Feb 12; 15(2); e0009023. doi: 10.1371/journal.pntd.0009023. Epub 2021 02 12

Seroprevalence and risk factors of exposure to COVID-19 in homeless people in Paris, France: a cross-sectional study.


BACKGROUND: During the COVID-19 lockdown period from March 17 to May 11, 2020, French authorities in Paris and its suburbs relocated people experiencing recurrent homelessness to emergency shelters, hotels, and large venues.

Roederer T Mollo B Vincent C Nikolay B Llosa AE Nesbitt R Vanhomwegen J Rose T Goyard S Anna F Torre C Fourrey E Simons E Hennequin W Mills C Luquero FJ
The Lancet. Public health 2021 Feb 05; doi: 10.1016/S2468-2667(21)00001-3. Epub 2021 02 05

Cost and cost-effectiveness of a real-world HCV treatment program among HIV-infected individuals in Myanmar.


INTRODUCTION: Over half of those hepatitis C virus (HCV)/HIV coinfected live in low-income and middle-income countries, and many remain undiagnosed or untreated.

Marquez LK Chaillon A Soe KP Johnson DC Zosso JM Incerti A Loarec A Nguyen A Walker JG Mafirakureva N Lo Re Iii V Wynn A McIntosh C Kiene SM Brodine S Garfein RS Vickerman P Martin NK
BMJ global health 2021 Feb ; 6(2); doi: 10.1136/bmjgh-2020-004181. Epub 2021 02 25
HIV health economics viral hepatitis

Concomitant Treatment of Chronic Hepatitis C With Direct-Acting Antivirals and Multidrug-Resistant Tuberculosis Is Effective and Safe.


We assessed effectiveness and safety of concomitant chronic hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) and multidrug-resistant tuberculosis (MDR-TB).

Melikyan N Huerga H Atshemyan H Kirakosyan O Sargsyants N Aydinyan T Saribekyan N Khachatryan N Oganezova I Falcao J Balkan S Hewison C
Open forum infectious diseases 2021 Feb ; 8(2); ofaa653. doi: 10.1093/ofid/ofaa653. Epub 2021 01 04
chronic hepatitis C direct-acting antiviral drugs multidrug-resistant tuberculosis sofosbuvir virus

Estimation of the correlates of protection of the rVSVΔG-ZEBOV-GP Zaire ebolavirus vaccine: a post-hoc analysis of data from phase 2/3 clinical trials.


BACKGROUND: Establishment of immune correlates of protection can provide a measurable criterion for assessing protection against infection or disease.

Rebecca F Grais Stephen B Kennedy Barbara E Mahon Sheri A Dubey ebecca J Grant-Klein R Ken Liu Jonathan Hartzel Beth-Ann Coller Carolee Welebob Mary E Hanson Jakub K Simon
Lancet Microbe 2021;2: e70–78;
Vaccination Ebola Clinical trial

Comparison of capillary versus venous blood for the diagnosis of Plasmodium falciparum malaria using rapid diagnostic tests.


We enrolled 250 febrile children in western Uganda to compare the results of malaria rapid diagnostic tests when using capillary versus venous blood. Participants were tested with four different RDT types.

Gorret AM Muhindo R Baguma E Ntaro M Mulogo EM Deutsch-Feldman M Juliano JJ Nyehangane D Boyce RM
The Journal of infectious diseases 2021 Jan 27; doi: 10.1093/infdis/jiab032. Epub 2021 01 27
Diagnostic Test Malaria Plasmodium

Immunogenicity and safety of fractional doses of yellow fever vaccines: a randomised, double-blind, non-inferiority trial.


BACKGROUND: Stocks of yellow fever vaccine are insufficient to cover exceptional demands for outbreak response. Fractional dosing has shown efficacy, but evidence is limited to the 17DD substrain vaccine.

Juan-Giner A Kimathi D Grantz KH Hamaluba M Kazooba P Njuguna P Fall G Dia M Bob NS Monath TP Barrett AD Hombach J Mulogo EM Ampeire I Karanja HK Nyehangane D Mwanga-Amumpaire J Cummings DAT Bejon P Warimwe GM Grais RF
Lancet (London, England) 2021 Jan 09; 397(10269); 119-127. doi: 10.1016/S0140-6736(20)32520-4. Epub 2021 01 10