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Depression and Suicidal Ideation Among HIV-Infected Adults Receiving Efavirenz Versus Nevirapine in Uganda: A Prospective Cohort Study.


Background: Evidence regarding potential adverse neuropsychiatric effects of efavirenz is conflicting, and data from sub-Saharan Africa, where 70% of persons living with HIV (PLHIV) reside and efavirenz is used as first-line therapy, a

Auteurs: Chang JL Tsai AC Musinguzi N Haberer JE Boum Y Muzoora C Bwana M Martin JN Hunt PW Bangsberg DR Siedner MJ
Référence de l'article: Annals of internal medicine 2018 Aug 07; 169(3); 146-155. doi: 10.7326/M17-2252. Epub 2018 06 26

Xpert MTB/RIF diagnosis of childhood tuberculosis from sputum and stool samples in a high TB-HIV-prevalent setting.


The Xpert MTB/RIF assay is a major advance for diagnosis of tuberculosis (TB) in high-burden countries but is limited in children by their difficulty to produce sputum.

Auteurs: Orikiriza P Nansumba M Nyehangane D Bastard M Mugisha IT Nansera D Mwanga-Amumpaire J Boum Y Kumbakumba E Bonnet M
Référence de l'article: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2018 Aug ; 37(8); 1465-1473. doi: 10.1007/s10096-018-3272-0. Epub 2018 05 08
Childhood tuberculosis Sputum Stool Xpert MTB/RIF

Evaluation of the SD bioline cholera rapid diagnostic test during the 2016 cholera outbreak in Lusaka, Zambia.


OBJECTIVE: To assess the performance of the SD Bioline Cholera Ag O1/O139 rapid diagnostic test (RDT) compared to a reference standard combining culture and PCR for the diagnosis of cholera cases during an outbreak.

Auteurs: Mwaba J Ferreras E Chizema-Kawesa E Mwimbe D Tafirenyika F Rauzier J Blake A Rakesh A Poncin M Stoitsova S Kwenda G Azman AS Chewe O Serafini M Lukwesa-Musyani C Cohuet S Quilici ML Luquero FJ Page AL
Référence de l'article: Tropical medicine & international health : TM & IH 2018 Aug ; 23(8); 834-840. doi: 10.1111/tmi.13084. Epub 2018 06 29
cholera choléra diagnostic accuracy outbreak précision diagnostique rapid diagnostic test test de diagnostic rapide épidémie

Distribution and Performance of Cardiovascular Risk Scores in a Mixed Population of HIV-Infected and Community-Based HIV-Uninfected Individuals in Uganda.


BACKGROUND: The utility and validity of cardiovascular diseases (CVD) risk scores are not well studied in sub-Saharan Africa.

Auteurs: Muiru AN Bibangambah P Hemphill L Sentongo R Kim JH Triant VA Bangsberg DR Tsai AC Martin JN Haberer JE Boum Y Plutzky J Hunt PW Okello S Siedner MJ
Référence de l'article: Journal of acquired immune deficiency syndromes (1999) 2018 Aug 01; 78(4); 458-464. doi: 10.1097/QAI.0000000000001696. Epub 2018 11 14

Pharmacokinetics of efavirenz in patients on antituberculosis treatment in high human immunodeficiency virus and tuberculosis burden countries: A systematic review.


AIMS: Efavirenz (EFV) and rifampicin-isoniazid (RH) are cornerstone drugs in human immunodeficiency virus (HIV)-tuberculosis (TB) coinfection treatment but with complex drug interactions, efficacy and safety challenges.

Auteurs: Atwine D Bonnet M Taburet AM
Référence de l'article: British journal of clinical pharmacology 2018 Aug ; 84(8); 1641-1658. doi: 10.1111/bcp.13600. Epub 2018 05 22
HIV/AIDS < infectious diseases adverse drug reactions antiretrovirals < infectious diseases genetics and pharmacogenetics pharmacokinetics

HIV Infection and risk of postpartum infection, complications and mortality in rural Uganda.


HIV infection may increase risk of postpartum infection and infection-related mortality. We hypothesized that postpartum infection incidence and attributable mortality in Mbarara, Uganda would be higher in HIV-infected than HIV-uninfected women.

Auteurs: Bebell LM Ngonzi J Siedner MJ Muyindike WR Bwana BM Riley LE Boum Y Bangsberg DR Bassett IV
Référence de l'article: AIDS care 2018 Aug ; 30(8); 943-953. doi: 10.1080/09540121.2018.1434119. Epub 2018 02 16
Africa HIV antiretroviral infection pregnancy puerperal sepsis

Estimating program coverage in the treatment of severe acute malnutrition: a comparative analysis of the validity and operational feasibility of two methods.


BACKGROUND: Many health programs can assess coverage using standardized cluster survey methods, but estimating the coverage of nutrition programs presents a special challenge due to low disease prevalence.

Auteurs: Isanaka S Hedt-Gauthier BL Grais RF Allen BGS
Référence de l'article: Population health metrics 2018 07 03; 16(1); 11. doi: 10.1186/s12963-018-0167-3. Epub 2018 07 03
Bayesian conjugate analysis Cluster survey Coverage SQUEAC Severe acute malnutrition Therapeutic feeding program

Is 6 months of bedaquiline enough? Results from the compassionate use of bedaquiline in Armenia and Georgia.


BACKGROUND AND SETTING: Bedaquiline (BDQ) was initially only available through compassionate use programmes.

Auteurs: Hewison C Bastard M Khachatryan N Kotrikadze T Hayrapetyan A Avaliani Z Kiria N Yegiazaryan L Chumburidze N Kirakosyan O Atshemyan H Qayyum S Lachenal N Varaine F Huerga H
Référence de l'article: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2018 Jul 01; 22(7); 766-772. doi: 10.5588/ijtld.17.0840. Epub 2018 06 19

Sub-national variation in measles vaccine coverage and outbreak risk: a case study from a 2010 outbreak in Malawi.


BACKGROUND: Despite progress towards increasing global vaccination coverage, measles continues to be one of the leading, preventable causes of death among children worldwide.

Auteurs: Kundrick A Huang Z Carran S Kagoli M Grais RF Hurtado N Ferrari M
Référence de l'article: BMC public health 2018 Jun 15; 18(1); 741. doi: 10.1186/s12889-018-5628-x. Epub 2018 06 15
Equity Measles Outbreak Vaccination

Safety of a heat-stable rotavirus vaccine among children in Niger: Data from a phase 3, randomized, double-blind, placebo-controlled trial.


BACKGROUND: Rotavirus remains a major cause of diarrhea among children under 5 years of age. The efficacy of RotaSIIL, a pentavalent rotavirus vaccine, was shown in an event-driven trial in Niger.

Auteurs: Coldiron ME Guindo O Makarimi R Soumana I Matar Seck A Garba S Macher E Isanaka S Grais RF
Référence de l'article: Vaccine 2018 06 14; 36(25); 3674-3680. doi: 10.1016/j.vaccine.2018.05.023. Epub 2018 05 08
Adverse event Diarrhea Gastroenteritis Intussusception Niger Rotavirus infection Rotavirus vaccines Safety