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Cost and cost-effectiveness of a simplified treatment model with direct-acting antivirals for chronic hepatitis C in Cambodia.


BACKGROUND & AIMS: In 2016, Médecins Sans Frontières established the first general population Hepatitis C virus (HCV) screening and treatment site in Cambodia, offering free direct acting antiviral (DAA) treatment.

Auteurs: Walker JG Mafirakureva N Iwamoto M Campbell L Kim CS Hastings RA Doussett JP Le Paih M Balkan S Marquardt T Maman D Loarec A Coast J Vickerman P
Référence de l'article: Liver international : official journal of the International Association for the Study of the Liver 2020 May 31; (); Array. doi: 10.1111/liv.14550. Epub 2020 05 31
Markov process cost effectiveness direct acting antiviral treatment healthcare costs hepatitis C low income population treatment costs

Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward.


Serological testing for SARS-CoV-2 has enormous potential to contribute to COVID-19 pandemic response efforts. However, the required performance characteristics of antibody tests will critically depend on the use case (individual-level vs.

Auteurs: Bryant JE Azman AS Ferrari MJ Arnold BF Boni MF Boum Y Hayford K Luquero FJ Mina MJ Rodriguez-Barraquer I Wu JT Wade D Vernet G Leung DT
Référence de l'article: Science immunology 2020 05 19; 5(47); Array. doi: 10.1126/sciimmunol.abc6347. Epub 2020 05 22

High sustained viral response rate in patients with hepatitis C using generic sofosbuvir and daclatasvir in Phnom Penh, Cambodia.


Safe and efficacious pan-genotypic direct-acting antiviral (DAA) regimens, such as sofosbuvir and daclatasvir (SOF+DCV)facilitate simplified models of care for hepatitis C virus (HCV).

Auteurs: Zhang M O'Keefe D Iwamoto M Sann K Kien A Hang V Brucker C Jolivet P Ly S Chhit D Balkan S Marquardt T Le Paih M Dousset JP
Référence de l'article: Journal of viral hepatitis 2020 May 02; (); Array. doi: 10.1111/jvh.13311. Epub 2020 05 02
Cambodia Daclatasvir Hepatitis C SVR12 Sofosbuvir

Adherence and Population Pharmacokinetic Properties of Amodiaquine When Used for Seasonal Malaria Chemoprevention in African Children.


Poor adherence to seasonal malaria chemoprevention (SMC) might affect the protective effectiveness of SMC.

Auteurs: Ding J Coldiron ME Assao B Guindo O Blessborn D Winterberg M Grais RF Koscalova A Langendorf C Tarning J
Référence de l'article: Clinical pharmacology and therapeutics 2020 May ; 107(5); 1179-1188. doi: 10.1002/cpt.1707. Epub 2019 12 31

Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis.


BACKGROUND: The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant liver stages.

Auteurs: Pfeffer DA Ley B Howes RE Adu P Alam MS Bansil P Boum Y Brito M Charoenkwan P Clements A Cui L Deng Z Egesie OJ Espino FE von Fricken ME Hamid MMA He Y Henriques G Khan WA Khim N Kim S Lacerda M Lon C Mekuria AH Menard D Monteiro W Nosten F Oo NN Pal S Palasuwan D Parikh S Pitaloka Pasaribu A Poespoprodjo JR Price DJ Roca-Feltrer A Roh ME Saunders DL Spring MD Sutanto I Ley-Thriemer K Weppelmann TA von Seidlein L Satyagraha AW Bancone G Domingo GJ Price RN
Référence de l'article: PLoS medicine 2020 May ; 17(5); e1003084. doi: 10.1371/journal.pmed.1003084. Epub 2020 05 14

Suspected paracetamol overdose in Monrovia, Liberia: a matched case-control study.


BACKGROUND: A cluster of cases of unexplained multi-organ failure was reported in children at Bardnesville Junction Hospital (BJH), Monrovia, Liberia.

Auteurs: Haidar MK Vogt F Takahashi K Henaff F Umphrey L Morton N Bawo L Kerkula J Ferner R Porten K Baud FJ
Référence de l'article: BMC pediatrics 2020 Mar 30; 20(1); 139. doi: 10.1186/s12887-020-2008-3. Epub 2020 03 30
Liberia Liver insufficiency Paediatrics Paracetamol

The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis.


BACKGROUND: Tens of millions of children are exposed to Mycobacterium tuberculosis globally every year; however, there are no contemporary estimates of the risk of developing tuberculosis in exposed children.

Auteurs: Martinez L Cords O Horsburgh CR Andrews JR
Référence de l'article: Lancet (London, England) 2020 Mar 21; 395(10228); 973-984. doi: 10.1016/S0140-6736(20)30166-5. Epub 2020 03 22

Field challenges to measles elimination in the Democratic Republic of the Congo.


BACKGROUND: During a measles epidemic, the Ministry of Public Health (MOH) of the Democratic Republic of the Congo conducted supplementary immunization activities (2016-SIA) from August 28-September 3, 2016 throughout Maniema Province.

Auteurs: Coulborn RM Nackers F Bachy C Porten K Vochten H Ndele E Van Herp M Bibala-Faray E Cohuet S Panunzi I
Référence de l'article: Vaccine 2020 Mar 17; 38(13); 2800-2807. doi: 10.1016/j.vaccine.2020.02.029. Epub 2020 02 25
Democratic Republic of the Congo Mass vaccination Measles vaccination Vaccination coverage Vaccine effectiveness