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Evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria and prevalence of pfhrp2/3 deletions in Aweil, South Sudan.


BACKGROUND: Rapid diagnostic tests (RDT) for malaria are the primary tool for malaria diagnosis in sub-Saharan Africa but the utility of the most commonly used histidine-rich protein 2 (HRP2) antigen-based tests is limited in high tran

Lynch E Jensen TO Assao B Chihana M Turuho T Nyehangane D Manyok JB Pasquale H Khim N Witkowski B Coldiron ME
Malaria journal 2022 Sep 09; 21(1); . doi: 10.1186/s12936-022-04280-w. Epub 2022 09 09
Histidine-rich protein 2 Malaria Plasmodium lactate dehydrogenase Rapid diagnostic test South Sudan

Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis.


BACKGROUND: BCG vaccines are given to more than 100 million children every year, but there is considerable debate regarding the effectiveness of BCG vaccination in preventing tuberculosis and death, particularly among older children an

Martinez L Cords O Liu Q Acuna-Villaorduna C Bonnet M Fox GJ Carvalho ACC Chan PC Croda J Hill PC Lopez-Varela E Donkor S Fielding K Graham SM Espinal MA Kampmann B Reingold A Huerga H Villalba JA Grandjean L Sotgiu G Egere U Singh S Zhu L Lienhardt C Denholm JT Seddon JA Whalen CC García-Basteiro AL Triasih R Chen C Singh J Huang LM Sharma S Hannoun D Del Corral H Mandalakas AM Malone LL Ling DL Kritski A Stein CM Vashishtha R Boulahbal F Fang CT Boom WH Netto EM Lemos AC Hesseling AC Kay A Jones-López EC Horsburgh CR Lange C Andrews JR
The Lancet. Global health 2022 Sep ; 10(9); . doi: 10.1016/S2214-109X(22)00283-2. Epub 2022 08 15

Validation of Three MicroScan Antimicrobial Susceptibility Testing Plates Designed for Low-Resource Settings.


Easy and robust antimicrobial susceptibility testing (AST) methods are essential in clinical bacteriology laboratories (CBL) in low-resource settings (LRS).

Ronat JB Oueslati S Natale A Kesteman T Elamin W Langendorf C Hardy L Vandenberg O Naas T
Diagnostics (Basel, Switzerland) 2022 Aug 30; 12(9); . doi: 10.3390/diagnostics12092106. Epub 2022 08 30
MicroScan antibiotic susceptibility testing clinical bacteriology low-resource settings

Cost-effectiveness of routine versus indicated antibiotic therapy in the management of severe wasting in children.


BACKGROUND: In the outpatient management of severe wasting, routine antibiotic therapy is recommended for all children upon admission regardless of whether clinical signs of infection are present.

Isanaka S Tang K Berthé F Grais RF Pandya A
Cost effectiveness and resource allocation : C/E 2022 Aug 03; 20(1); . doi: 10.1186/s12962-022-00374-z. Epub 2022 08 03
Antibiotic therapy Cost-effectiveness Niger Severe acute malnutrition Wasting

Viral suppression and HIV-1 drug resistance 1 year after pragmatic transitioning to dolutegravir first-line therapy in Malawi: a prospective cohort study.


BACKGROUND: Many countries are now replacing non-nucleoside reverse transcriptase inhibitor (NNRTI)-based first-line antiretroviral therapy (ART) with a regimen containing tenofovir disoproxil fumarate, lamivudine, and dolutegravir (TL

Schramm B Temfack E Descamps D Nicholas S Peytavin G Bitilinyu-Bangoh JE Storto A Lê MP Abdi B Ousley J Kalua T Calvez V Jahn A Marcelin AG Szumilin E
The lancet. HIV 2022 Aug ; 9(8); . doi: 10.1016/S2352-3018(22)00136-9. Epub 2022 07 29

Burden and risk factors for relapse following successful treatment of uncomplicated severe acute malnutrition in young children: Secondary analysis from a randomised trial in Niger.


This study aimed to quantify the burden of relapse following successful treatment for uncomplicated severe acute malnutrition (SAM) and to identify associated risk factors in rural Niger.

Bliznashka L Grantz KH Botton J Berthé F Garba S Hanson KE Grais RF Isanaka S
Maternal & child nutrition 2022 Jul 21; . doi: 10.1111/mcn.13400. Epub 2022 07 21
Niger community-based management of acute malnutrition discharge hospitalisation relapse severe acute malnutrition wasting