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Individual and household risk factors for Ebola disease among household contacts in Mubende and Kassanda districts, Uganda, 2022.


BACKGROUND: In 2022, an Ebola disease outbreak caused by Sudan virus (SUDV) occurred in Uganda, primarily affecting Mubende and Kassanda districts.

Migamba SM Ardiet DL Migisha R Nansikombi HT Agaba B Naiga HN Wanyana M Zalwango JF Atuhaire I Kawungezi PC Zalwango MG Simbwa B Kadobera D Ario AR Harris JR
BMC infectious diseases 2024 May 30; 24(1); . doi: 10.1186/s12879-024-09439-1. Epub 2024 05 30
Ebola disease Sudan virus Sudan virus disease Uganda

Sputum culture reversion in longer treatments with bedaquiline, delamanid, and repurposed drugs for drug-resistant tuberculosis.


Sputum culture reversion after conversion is an indicator of tuberculosis (TB) treatment failure.

Kho S Seung KJ Huerga H Bastard M Khan PY Mitnick CD Rich ML Islam S Zhizhilashvili D Yeghiazaryan L Nikolenko EN Zarli K Adnan S Salahuddin N Ahmed S Vargas ZHR Bekele A Shaimerdenova A Tamirat M Gelin A Vilbrun SC Hewison C Khan U Franke M
Nature communications 2024 May 09; 15(1); . doi: 10.1038/s41467-024-48077-8. Epub 2024 05 09

The genetic diversity of Nipah virus across spatial scales.


BACKGROUND: Nipah virus (NiV), a highly lethal virus in humans, circulates in Pteropus bats throughout South and Southeast Asia. Difficulty in obtaining viral genomes from bats means we have a poor understanding of NiV diversity.

Cortes-Azuero O Lefrancq N Nikolay B McKee C Cappelle J Hul V Ou TP Hoem T Lemey P Rahman MZ Islam A Gurley ES Duong V Salje H
The Journal of infectious diseases 2024 Apr 29; . doi: 10.1093/infdis/jiae221. Epub 2024 04 29
Nipah virus Pteropus bats disease modelling emerging pathogens phylogenetics

Methodological issues of retrospective surveys for measuring mortality of highly clustered diseases: case study of the 2014-16 Ebola outbreak in Bo District, Sierra Leone.


BACKGROUND: There is a lack of empirical data on design effects (DEFF) for mortality rate for highly clustered data such as with Ebola virus disease (EVD), along with a lack of documentation of methodological limitations and operationa

Caleo G Lokuge K Kardamanidis K Greig J Belava J Kilbride E Sayui Turay A Saffa G Kremer R Grandesso F Danis K Sprecher A Luca Di Tanna G Baker H Weiss HA
Global health action 2024 Dec 31; 17(1); . doi: 10.1080/16549716.2024.2331291. Epub 2024 04 26
Ebola virus disease cluster surveys design effects highly-clustered data mortality

Integration of HIV Testing in a Community Intervention for Tuberculosis Screening Among Household Contacts of Patients with Tuberculosis in Cameroon and Uganda.


INTRODUCTION: People living with HIV are considered at higher risk of developing severe forms of tuberculosis (TB) disease. Providing HIV testing to TB-exposed people is therefore critical.

Youngui BT Atwine D Otai D Vasiliu A Ssekyanzi B Sih C Kana R Arinaitwe R Cuer B Simo L Okello R Tchendjou P Casenghi M Kuate AK Turyahabwe S Cohn J Bonnet M Tchounga BK
Journal of acquired immune deficiency syndromes (1999) 2024 Apr 15; 95(5); . doi: 10.1097/QAI.0000000000003379. Epub 2024 03 11

Cost-effectiveness and budget impact of decentralising childhood tuberculosis diagnosis in six high tuberculosis incidence countries: a mathematical modelling study.


BACKGROUND: The burden of childhood tuberculosis remains high globally, largely due to under-diagnosis.

d'Elbée M Harker M Mafirakureva N Nanfuka M Huyen Ton Nu Nguyet M Taguebue JV Moh R Khosa C Mustapha A Mwanga-Amumpere J Borand L Nolna SK Komena E Cumbe S Mugisha J Natukunda N Mao TE Wittwer J Bénard A Bernard T Sohn H Bonnet M Wobudeya E Marcy O Dodd PJ
EClinicalMedicine 2024 Apr ; 70; . doi: 10.1016/j.eclinm.2024.102528. Epub 2024 03 21
Decentralisation Diagnosis Economic evaluation Low- and middle-income countries Paediatric tuberculosis