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Outcomes of AIDS-associated Kaposi sarcoma in Mozambique after treatment with pegylated liposomal doxorubicin.


BACKGROUND: Kaposi's sarcoma (KS) is a common HIV-associated malignancy frequently associated with poor outcomes. It is the most frequently diagnosed cancer in major cities of Mozambique.

Coldiron ME Gutierrez Zamudio AG Manuel R Luciano G Rusch B Ciglenecki I Telnov A Grais RF Trellu LT Molfino L
Infectious agents and cancer 2021 Jan 07; 16(1); 2. doi: 10.1186/s13027-020-00341-4. Epub 2021 01 07
AIDS-related opportunistic infections Acquired immunodeficiency syndrome Doxorubicin Kaposi sarcoma Mozambique

Smartphone-Based Ophthalmic Imaging Compared to Spectral Domain Optical Coherence Tomography Assessment of Vertical Cup-to-Disc Ratio among Adults in Southwestern Uganda.


PRCIS: Using optical coherence tomography measurements as a reference standard for vertical cup-to-disc ratio (vCDR), a smartphone-based ophthalmic camera has a sensitivity of 67.7% and specificity of 96.7% to detect a vCDR greater tha

Idriss BR Tran TM Atwine D Chang RT Myung D Onyango J
Journal of glaucoma 2020 Dec 29; Publish Ahead of Print doi: 10.1097/IJG.0000000000001779. Epub 2020 12 29

Urine lipoarabinomannan (LAM) testing for all HIV patients hospitalized in the medical wards identifies a large proportion of patients with tuberculosis at risk of death.


BACKGROUND: Diagnosing tuberculosis (TB), the leading cause of death in people with HIV, remains a challenge in resource-limited countries.

Helena Huerga Sekai Chenai Mathabire Rucker Mathieu Bastard James Mpunga Isabel Amoros Quiles Chimwemwe Kabaghe Laura Sannino Elisabeth Szumilin
Open Forum Infectious Diseases; ofaa639;; 23 December 2020
Inpatients CD4 lymphocyte count Point-of-Care testing Death Low-income countries

Feasibility of satellite image and GIS sampling for population representative surveys: a case study from rural Guatemala.


BACKGROUND: Population-representative household survey methods require up-to-date sampling frames and sample designs that minimize time and cost of fieldwork especially in low- and middle-income countries.

Miller AC Rohloff P Blake A Dhaenens E Shaw L Tuiz E Grandesso F Mendoza Montano C Thomson DR
International journal of health geographics 2020 Dec 05; 19(1); 56. doi: 10.1186/s12942-020-00250-0. Epub 2020 12 05
Guatemala Population-representative study Sample selection Sampling frame Simple random sample

Successive epidemic waves of cholera in South Sudan between 2014 and 2017: a descriptive epidemiological study.


BACKGROUND: Between 2014 and 2017, successive cholera epidemics occurred in South Sudan within the context of civil war, population displacement, flooding, and drought.

Jones FK Wamala JF Rumunu J Mawien PN Kol MT Wohl S Deng L Pezzoli L Omar LH Lessler J Quilici ML Luquero FJ Azman AS
The Lancet. Planetary health 2020 Dec ; 4(12); e577-e587. doi: 10.1016/S2542-5196(20)30255-2. Epub 2020 12 24

A telephone based assessment of the health situation in the far north region of Cameroon.


BACKGROUND: In 2017, Field access was considerably limited in the Far North region of Cameroon due to the conflict.

Gignoux EMH Donfack Sontsa OT Mudasiru A Eyong J Ntone R Tamakloe Koku M Adji DM Etoundi A Boum Y Jamet C Cabrol JC Porten K
Conflict and health 2020 Nov 30; 14(1); 82. doi: 10.1186/s13031-020-00327-4. Epub 2020 11 30
Conflict Healthcare Mortality Telephone

Evaluating Ten Commercially-Available SARS-CoV-2 Rapid Serological Tests Using the STARD (Standards for Reporting of Diagnostic Accuracy Studies) Method.


Numerous SARS-CoV-2 rapid serological tests have been developed, but their accuracy has usually been assessed using very few samples, and rigorous comparisons between these tests are scarce.

Dortet L Ronat JB Vauloup-Fellous C Langendorf C Mendels DA Emeraud C Oueslati S Girlich D Chauvin A Afdjei A Bernabeu S Le Pape S Kallala R Rochard A Verstuyft C Fortineau N Roque-Afonso AM Naas T
Journal of clinical microbiology 2020 Nov 25; doi: 10.1128/JCM.02342-20. Epub 2020 11 25

MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era.


BACKGROUND: Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays due to the RpoB I491F resistance mutation are threatening the control of MD

Beckert P Sanchez-Padilla E Merker M Dreyer V Kohl TA Utpatel C Köser CU Barilar I Ismail N Omar SV Klopper M Warren RM Hoffmann H Maphalala G Ardizzoni E de Jong BC Kerschberger B Schramm B Andres S Kranzer K Maurer FP Bonnet M Niemann S
Genome medicine 2020 Nov 25; 12(1); 104. doi: 10.1186/s13073-020-00793-8. Epub 2020 11 25
Diagnostice escape MDR outbreak strains Multidrug resistance Resistance evolution Treatment escape Treatment failure Tuberculosis

Integration of Traditional Healers in Human African Trypanosomiasis Case Finding in Central Africa: A Quasi-Experimental Study.


BACKGROUND: Based on the premise that Africans in rural areas seek health care from traditional healers, this study investigated a collaborative model between traditional healers and the national Human African Trypanosomiasis (HAT) pro

Kwedi Nolna S Ntonè R Fouda Mbarga N Mbainda S Mutangala W Boua B Niba M Okoko A
Tropical medicine and infectious disease 2020 Nov 17; 5(4); doi: 10.3390/tropicalmed5040172. Epub 2020 11 17
Trypanosomiasis case finding screening sleeping sickness, case finding, screening, traditional healer traditional healer