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Tuberculosis screening among HIV-positive inpatients: a systematic review and individual participant data meta-analysis.


BACKGROUND: Since 2011, WHO has recommended that HIV-positive inpatients be routinely screened for tuberculosis with the WHO four-symptom screen (W4SS) and, if screened positive, receive a molecular WHO-recommended rapid diagnostic tes

Dhana A Hamada Y Kengne AP Kerkhoff AD Rangaka MX Kredo T Baddeley A Miller C Gupta-Wright A Fielding K Wood R Huerga H Rücker SCM Heidebrecht C Wilson D Bjerrum S Johansen IS Thit SS Kyi MM Hanson J Barr DA Meintjes G Maartens G
The lancet. HIV 2022 Mar 17; . doi: 10.1016/S2352-3018(22)00002-9. Epub 2022 03 17

Protocol for a phase 3 trial to evaluate the effectiveness and safety of a heterologous, two-dose vaccine for Ebola virus disease in the Democratic Republic of the Congo.


INTRODUCTION: Ebola virus disease (EVD) continues to be a significant public health problem in sub-Saharan Africa, especially in the Democratic Republic of the Congo (DRC).

Watson-Jones D Kavunga-Membo H Grais RF Ahuka S Roberts N Edmunds WJ Choi EM Roberts CH Edwards T Camacho A Lees S Leyssen M Spiessens B Luhn K Douoguih M Hatchett R Bausch DG Muyembe JJ
BMJ open 2022 03 08; 12(3); . doi: 10.1136/bmjopen-2021-055596. Epub 2022 03 08
Ebola infectious diseases public health tropical medicine vaccine

Safety and effectiveness outcomes from a 14-country cohort of patients with multi-drug resistant tuberculosis treated concomitantly with bedaquiline, delamanid and other second-line drugs.


BACKGROUND: Concomitant use of bedaquiline (Bdq) and delamanid (Dlm) for multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) has raised concerns about a potentially poor risk-benefit ratio.

Huerga H Khan U Bastard M Mitnick CD Lachenal N Khan PY Seung KJ Melikyan N Ahmed S Rich ML Varaine F Osso E Rashitov M Salahuddin N Salia G Sánchez E Serobyan A Siddiqui MR Tefera DG Vetushko D Yeghiazaryan L Holtzman D Islam S Kumsa A Leblanc GJ Leonovich O Mamsa S Manzur-Ul-Alam M Myint Z Padayachee S Franke MF Hewison C
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2022 Mar 04; doi: 10.1093/cid/ciac176. Epub 2022 03 04
adverse events combination therapy endTB linezolid

Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis.


INTRODUCTION: Adolescents living with HIV are subject to multiple co-morbidities, including growth retardation and immunodeficiency.

Jesson J Crichton S Quartagno M Yotebieng M Abrams EJ Chokephaibulkit K Le Coeur S Aké-Assi MH Patel K Pinto J Paul M Vreeman R Davies MA Ben-Farhat J Van Dyke R Judd A Mofenson L Vicari M Seage G Bekker LG Essajee S Gibb D Penazzato M Collins IJ Wools-Kaloustian K Slogrove A Powis K Williams P Matshaba M Thahane L Nyasulu P Lukhele B Mwita L Kekitiinwa-Rukyalekere A Wanless S Goetghebuer T Thorne C Warszawski J Galli L van Rossum AMC Giaquinto C Marczynska M Marques L Prata F Ene L Okhonskaya L Navarro M Frick A Naver L Kahlert C Volokha A Chappell E Pape JW Rouzier V Marcelin A Succi R Sohn AH Kariminia A Edmonds A Lelo P Lyamuya R Ogalo EA Odhiambo FA Haas AD Bolton C Muhairwe J Tweya H Sylla M D'Almeida M Renner L Abzug MJ Oleske J Purswani M Teasdale C Nuwagaba-Biribonwoha H Goodall R Leroy V
Journal of the International AIDS Society 2022 Mar ; 25(3); e25871. doi: 10.1002/jia2.25871. Epub 2022 03 07
CD4 HIV adolescent cohort studies growth perinatally acquired

Effectiveness of a monthly schedule of follow-up for the treatment of uncomplicated severe acute malnutrition in Sokoto, Nigeria: A cluster randomized crossover trial.


BACKGROUND: Community-based management of severe acute malnutrition (SAM) involves weekly or biweekly outpatient clinic visits for clinical surveillance and distribution of therapeutic foods.

Hitchings MDT Berthé F Aruna P Shehu I Hamza MA Nanama S Steve-Edemba C Grais RF Isanaka S
PLoS medicine 2022 Mar ; 19(3); e1003923. doi: 10.1371/journal.pmed.1003923. Epub 2022 03 01

Snakebite epidemiology in humans and domestic animals across the Terai region in Nepal: a multicluster random survey.


BACKGROUND: Each year, 2 million people worldwide are bitten by snakes, resulting in an estimated 81 000-138 000 deaths.

Alcoba G Sharma SK Bolon I Ochoa C Babo Martins S Subedi M Shah B Ghimire A Gignoux E Luquero F Ruiz de Castañeda R Ray N Chappuis F
The Lancet. Global health 2022 Mar ; 10(3); e398-e408. doi: 10.1016/S2214-109X(22)00028-6. Epub 2022 02 21

Knowledge, attitudes and practices on childhood TB among healthcare workers.


Increasing childhood TB case detection requires the deployment of diagnostic services at peripheral healthcare level. Capacity and readiness of healthcare workers (HCWs) are key to the delivery of innovative approaches.

Joshi B Font H Wobudeya E Nanfuka M Kobusingye A Mwanga-Amumpaire J Natukunda N Turyahabwe S Borand L Mao TE Dim B Ferhi R Moh R Kouakou J Aka Bony R Breton G Mustapha A Matata L Foray L Detjen A Verkuijl S Sekadde M Khosa C Mbassa V Taguebue JV Kwedi Nolna S Bonnet M Marcy O Orne-Gliemann J
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2022 Mar 01; 26(3); 243-251. doi: 10.5588/ijtld.21.0317. Epub 2022 02 24

Permethrin-treated baby wraps for the prevention of malaria: results of a randomized controlled pilot study in rural Uganda.


BACKGROUND: Progress against malaria has stalled and may even be slipping backwards in high-burden countries.

Boyce RM Muhindo E Baguma E Muhindo R Shem B François R Hawke S Shook-Sa BE Ntaro M Nalusaji A Nyehangane D Reyes R Juliano JJ Siedner MJ Staedke SG Mulogo EM
Malaria journal 2022 Feb 23; 21(1); 63. doi: 10.1186/s12936-022-04086-w. Epub 2022 02 23
Insecticide-treated clothing Malaria Permethrin Plasmodium Prevention

Inference is bliss: Simulation for power estimation for an observational study of a cholera outbreak intervention.


BACKGROUND: The evaluation of ring vaccination and other outbreak-containment interventions during severe and rapidly-evolving epidemics presents a challenge for the choice of a feasible study design, and subsequently, for the estimati

Ratnayake R Checchi F Jarvis CI Edmunds WJ Finger F
PLoS neglected tropical diseases 2022 Feb 16; 16(2); e0010163. doi: 10.1371/journal.pntd.0010163. Epub 2022 02 16