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Pharmacokinetics of efavirenz in patients on antituberculosis treatment in high human immunodeficiency virus and tuberculosis burden countries: A systematic review.


AIMS: Efavirenz (EFV) and rifampicin-isoniazid (RH) are cornerstone drugs in human immunodeficiency virus (HIV)-tuberculosis (TB) coinfection treatment but with complex drug interactions, efficacy and safety challenges.

Auteurs: Atwine D Bonnet M Taburet AM
Référence de l'article: British journal of clinical pharmacology 2018 Aug ; 84(8); 1641-1658. doi: 10.1111/bcp.13600. Epub 2018 05 22
HIV/AIDS < infectious diseases adverse drug reactions antiretrovirals < infectious diseases genetics and pharmacogenetics pharmacokinetics

HIV Infection and risk of postpartum infection, complications and mortality in rural Uganda.


HIV infection may increase risk of postpartum infection and infection-related mortality. We hypothesized that postpartum infection incidence and attributable mortality in Mbarara, Uganda would be higher in HIV-infected than HIV-uninfected women.

Auteurs: Bebell LM Ngonzi J Siedner MJ Muyindike WR Bwana BM Riley LE Boum Y Bangsberg DR Bassett IV
Référence de l'article: AIDS care 2018 Aug ; 30(8); 943-953. doi: 10.1080/09540121.2018.1434119. Epub 2018 02 16
Africa HIV antiretroviral infection pregnancy puerperal sepsis

Estimating program coverage in the treatment of severe acute malnutrition: a comparative analysis of the validity and operational feasibility of two methods.


BACKGROUND: Many health programs can assess coverage using standardized cluster survey methods, but estimating the coverage of nutrition programs presents a special challenge due to low disease prevalence.

Auteurs: Isanaka S Hedt-Gauthier BL Grais RF Allen BGS
Référence de l'article: Population health metrics 2018 07 03; 16(1); 11. doi: 10.1186/s12963-018-0167-3. Epub 2018 07 03
Bayesian conjugate analysis Cluster survey Coverage SQUEAC Severe acute malnutrition Therapeutic feeding program

Is 6 months of bedaquiline enough? Results from the compassionate use of bedaquiline in Armenia and Georgia.


BACKGROUND AND SETTING: Bedaquiline (BDQ) was initially only available through compassionate use programmes.

Auteurs: Hewison C Bastard M Khachatryan N Kotrikadze T Hayrapetyan A Avaliani Z Kiria N Yegiazaryan L Chumburidze N Kirakosyan O Atshemyan H Qayyum S Lachenal N Varaine F Huerga H
Référence de l'article: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2018 Jul 01; 22(7); 766-772. doi: 10.5588/ijtld.17.0840. Epub 2018 06 19

Sub-national variation in measles vaccine coverage and outbreak risk: a case study from a 2010 outbreak in Malawi.


BACKGROUND: Despite progress towards increasing global vaccination coverage, measles continues to be one of the leading, preventable causes of death among children worldwide.

Auteurs: Kundrick A Huang Z Carran S Kagoli M Grais RF Hurtado N Ferrari M
Référence de l'article: BMC public health 2018 Jun 15; 18(1); 741. doi: 10.1186/s12889-018-5628-x. Epub 2018 06 15
Equity Measles Outbreak Vaccination

Safety of a heat-stable rotavirus vaccine among children in Niger: Data from a phase 3, randomized, double-blind, placebo-controlled trial.


BACKGROUND: Rotavirus remains a major cause of diarrhea among children under 5 years of age. The efficacy of RotaSIIL, a pentavalent rotavirus vaccine, was shown in an event-driven trial in Niger.

Auteurs: Coldiron ME Guindo O Makarimi R Soumana I Matar Seck A Garba S Macher E Isanaka S Grais RF
Référence de l'article: Vaccine 2018 06 14; 36(25); 3674-3680. doi: 10.1016/j.vaccine.2018.05.023. Epub 2018 05 08
Adverse event Diarrhea Gastroenteritis Intussusception Niger Rotavirus infection Rotavirus vaccines Safety

Immunogenicity and Protection From a Single Dose of Internationally Available Killed Oral Cholera Vaccine: A Systematic Review and Metaanalysis.


In addition to improved water supply and sanitation, the 2-dose killed oral cholera vaccine (OCV) is an important tool for the prevention and control of cholera.

Auteurs: Lopez AL Deen J Azman AS Luquero FJ Kanungo S Dutta S von Seidlein L Sack DA
Référence de l'article: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018 Jun 01; 66(12); 1960-1971. doi: 10.1093/cid/cix1039. Epub 2018 11 13

Access to care for non-communicable diseases in Mosul, Iraq between 2014 and 2017: a rapid qualitative study.


During June 2014 to April 2017, the population of Mosul, Iraq lived in a state of increasing isolation from the rest of Iraq due to the city's occupation by the Islamic State group.

Auteurs: Baxter LM Eldin MS Al Mohammed A Saim M Checchi F
Référence de l'article: Conflict and health 2018 ; 12(); 48. doi: 10.1186/s13031-018-0183-8. Epub 2018 12 29
Access to healthcare Conflict Diabetes Humanitarian Hypertension Iraq Non-communicable diseases War

Field evaluation of near point of care Cepheid GeneXpert HIV-1 Qual for early infant diagnosis.


BACKGROUND: Access to point-of-care HIV testing shortens turn-around times, time to diagnosis and reduces loss to follow-up hence minimizing barriers to early linkage to care and treatment among HIV infected infants.

Auteurs: Opollo VS Nikuze A Ben-Farhat J Anyango E Humwa F Oyaro B Wanjala S Omwoyo W Majiwa M Akelo V Zeh C Maman D
Référence de l'article: PloS one 2018 ; 13(12); e0209778. doi: 10.1371/journal.pone.0209778. Epub 2018 12 27

Impact of "test and treat" recommendations on eligibility for antiretroviral treatment: Cross sectional population survey data from three high HIV prevalence countries.


BACKGROUND: Latest WHO guidelines recommend starting HIV-positive individuals on antiretroviral therapy treatment (ART) regardless of CD4 count. We assessed additional impact of adopting new WHO guidelines.

Auteurs: Chihana ML Huerga H Van Cutsem G Ellman T Wanjala S Masiku C Szumilin E Etard JF Davies MA Maman D
Référence de l'article: PloS one 2018 ; 13(11); e0207656. doi: 10.1371/journal.pone.0207656. Epub 2018 11 26