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A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics.


BACKGROUND: Although several experimental therapeutics for Ebola virus disease (EVD) have been developed, the safety and efficacy of the most promising therapies need to be assessed in the context of a randomized, controlled trial.

Auteurs: Mulangu S Dodd LE Davey RT Tshiani Mbaya O Proschan M Mukadi D Lusakibanza Manzo M Nzolo D Tshomba Oloma A Ibanda A Ali R Coulibaly S Levine AC Grais R Diaz J Lane HC Muyembe-Tamfum JJ Sivahera B Camara M Kojan R Walker R Dighero-Kemp B Cao H Mukumbayi P Mbala-Kingebeni P Ahuka S Albert S Bonnett T Crozier I Duvenhage M Proffitt C Teitelbaum M Moench T Aboulhab J Barrett K Cahill K Cone K Eckes R Hensley L Herpin B Higgs E Ledgerwood J Pierson J Smolskis M Sow Y Tierney J Sivapalasingam S Holman W Gettinger N Vallée D Nordwall J
Référence de l'article: The New England journal of medicine 2019 Nov 27; (); Array. doi: 10.1056/NEJMoa1910993. Epub 2019 11 27

Randomized, double-blinded, controlled non-inferiority trials evaluating the immunogenicity and safety of fractional doses of Yellow Fever vaccines in Kenya and Uganda


INTRODUCTION: Yellow fever is endemic in specific regions of sub-Saharan Africa and the Americas, with recent epidemics occurring on both continents.

Auteurs: Derick Kimathi Aitana Juan Philip Bejon Rebecca F. Grais George M. Warimwe
Référence de l'article: Wellcome Open Research 2019 Nov 21; 4:182;10.12688/wellcomeopenres.15579.1
Yellow Fever Vaccination

Safety of the rVSV ZEBOV vaccine against Ebola Zaire among frontline workers in Guinea.


BACKGROUND: As part of the ring vaccination trial in Guinea, Front Line Workers were invited to participate in a sub-study to provide additional information on the immunogenicity and safety of rVSVΔG/ZEBOV-GP.

Auteurs: Juan-Giner A Tchaton M Jemmy JP Soumah A Boum Y Faga EM Cisse M Grais RF
Référence de l'article: Vaccine 2018 Sep 25; (); Array. doi: 10.1016/j.vaccine.2018.09.009. Epub 2018 09 25
Ebola virus disease Guinea Health-care workers Safety Surveillance rVSV vaccine

Culture conversion at six months in patients receiving delamanid-containing regimens for the treatment of multidrug-resistant tuberculosis.


Delamanid should be effective against highly resistant strains of M. tuberculosis, but uptake has been slow globally.

Auteurs: Seung KJ Khan P Franke MF Ahmed S Aiylchiev S Alam M Putri FA Bastard M Docteur W Gottlieb G Hewison C Islam S Khachatryan N Kotrikadze T Khan U Kumsa A Lecca L Tassew YM Melikyan N Naing YY Oyewusi L Rich M Wanjala S Yedilbayev A Huerga H Mitnick CD
Référence de l'article: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019 Nov 02; (); Array. doi: 10.1093/cid/ciz1084. Epub 2019 11 02
antitubercular agents delamanid extensively drug-resistant tuberculosis multidrug-resistant tuberculosis

Distribution of advanced HIV disease from three high HIV prevalence settings in Sub-Saharan Africa: a secondary analysis data from three population-based cross-sectional surveys in Eshowe (South Africa), Ndhiwa (Kenya) and Chiradzulu (Malawi).


: Despite substantial progress in antiretroviral therapy (ART) scale up, some people living with HIV (PLHIV) continue to present with advanced HIV disease, contributing to ongoing HIV-related morbidity and mortality.: We aimed to quantify population-le

Auteurs: Chihana ML Huerga H Van Cutsem G Ellman T Goemaere E Wanjala S Masiku C Szumilin E Etard JF Maman D Davies MA
Référence de l'article: Global health action 2019 ; 12(1); 1679472. doi: 10.1080/16549716.2019.1679472. Epub 2019 11 04
ART Africa CD4 HIV population-level

Evaluation of OMNIgene® SPUTUM and ethanol reagent for preservation of sputum prior to Xpert and culture testing in Uganda.


Xpert MTB/RIF (Xpert) and culture are the most reliable methods for tuberculosis diagnosis but are still poorly accessible in many low resource countries.

Auteurs: Ardizzoni E Orikiriza P Ssuuna C Nyehangane D Gumsboga M Taremwa IM Turyashemererwa E Mwanga-Amumpaire J Langendorf C Bonnet M
Référence de l'article: Journal of clinical microbiology 2019 Oct 16; (); Array. doi: 10.1128/JCM.00810-19. Epub 2019 10 16

Hand hygiene compliance and environmental contamination with gram-negative bacilli in a rural hospital in Madarounfa, Niger.


BACKGROUND: Healthcare-associated infections pose a major, yet often preventable risk to patient safety.

Auteurs: Tang K Berthé F Nackers F Hanson K Mambula C Langendorf C Marquer C Isanaka S
Référence de l'article: Transactions of the Royal Society of Tropical Medicine and Hygiene 2019 Oct 14; (); Array. doi: 10.1093/trstmh/trz070. Epub 2019 10 14
Niger gram-negative bacilli hand hygiene healthcare personnel healthcare-associated infections

Factors influencing participation in an Ebola vaccine trial among front-line workers in Guinea.


BACKGROUND: Alongside the clinical aspects of the immunogenicity and safety trial of an Ebola vaccine deployed among front-line workers, a qualitative study was conducted to describe motivations behind individuals' decisions to partici

Auteurs: Grantz KH Claudot P Kambala M Kouyaté M Soumah A Boum Y Juan-Giner A Jemmy JP Cummings DAT Grais RF
Référence de l'article: Vaccine 2019 Oct 14; (); Array. doi: 10.1016/j.vaccine.2019.09.094. Epub 2019 10 14
Ebola virus disease Guinea Healthcare workers Qualitative Research design rVSV vaccine

Mobile community-based active case-finding for tuberculosis among older populations in rural Cambodia.


To systematically screen older rural populations in Cambodia for tuberculosis (TB) and develop an effective active case-finding (ACF) model for this TB high-risk group.

Auteurs: Camelique O Scholtissen S Dousset JP Bonnet M Bastard M Hewison C
Référence de l'article: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2019 Oct 01; 23(10); 1107-1114. doi: 10.5588/ijtld.18.0611. Epub 2019 10 19

What is the best culture conversion prognostic marker for patients treated for multidrug-resistant tuberculosis?


Identification of good prognostic marker for tuberculosis (TB) treatment response is a necessary step on the path towards a surrogate marker to reduce TB trial duration.

Auteurs: Bastard M Sanchez-Padilla E Hayrapetyan A Kimenye K Khurkhumal S Dlamini T Fadul Perez S Telnov A Hewison C Varaine F Bonnet M
Référence de l'article: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2019 Oct 01; 23(10); 1060-1067. doi: 10.5588/ijtld.18.0649. Epub 2019 10 19