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Impact and cost-effectiveness of rotavirus vaccination in Niger: a modelling study evaluating alternative rotavirus vaccines.


OBJECTIVES: To evaluate the cost-effectiveness of alternative rotavirus vaccines in Niger, using UNIVAC, a proportionate outcomes model.

Debellut F Tang K Clark A Pecenka C Assao B Guindo O Grais RF Isanaka S
BMJ open 2022 Oct 05; 12(10); . doi: 10.1136/bmjopen-2022-061673. Epub 2022 10 05
Health economics Health policy Paediatric infectious disease & immunisation Public health

TB screening, prevention and treatment cascade in a Malawi prison.


Incarcerated individuals, especially in high HIV and TB burden settings, are at increased risk of latent TB infection and/or TB disease. We implemented a comprehensive HIV-TB intervention in a Malawi prison and studied its feasibility.

Mangochi P Bossard C Catacutan C Van Laeken D Kwitonda C Ortuno R Chiwaula L Meis M Abura A Furin J Mpunga J Goemare E Ellman T Garone D Ferlazzo G Isaakidis P
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2022 Oct 01; 26(10); . doi: 10.5588/ijtld.22.0115. Epub 2022 09 28

Anthropometric deficits and the associated risk of death by age and sex in children aged 6-59 months: A meta-analysis.


Risk of death from undernutrition is thought to be higher in younger than in older children, but evidence is mixed. Research also demonstrates sex differences whereby boys have a higher prevalence of undernutrition than girls.

Thurstans S Wrottesley SV Fenn B Khara T Bahwere P Berkley JA Black RE Boyd E Garenne M Isanaka S Lelijveld N McDonald CM Mertens A Mwangome M O'Brien KS Stobaugh H Taneja S West KP Guerrero S Kerac M Briend A Myatt M
Maternal & child nutrition 2022 Sep 27; . doi: 10.1111/mcn.13431. Epub 2022 09 27
age mortality sex stunting underweight wasting

Genetic Variants of Glucose-6-Phosphate Dehydrogenase and Their Associated Enzyme Activity: A Systematic Review and Meta-Analysis.


Low glucose-6-phosphate dehydrogenase enzyme (G6PD) activity is a key determinant of drug-induced haemolysis. More than 230 clinically relevant genetic variants have been described.

Pfeffer DA Satyagraha AW Sadhewa A Alam MS Bancone G Boum Y Brito M Cui L Deng Z Domingo GJ He Y Khan WA Kibria MG Lacerda M Menard D Monteiro W Pal S Parikh S Roca-Feltrer A Roh M Sirdah MM Wang D Huang Q Howes RE Price RN Ley B
Pathogens (Basel, Switzerland) 2022 Sep 14; 11(9); . doi: 10.3390/pathogens11091045. Epub 2022 09 14
G6PD activity G6PD deficiency G6PD genotype glucose-6-phosphate dehydrogenase

Evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria and prevalence of pfhrp2/3 deletions in Aweil, South Sudan.


BACKGROUND: Rapid diagnostic tests (RDT) for malaria are the primary tool for malaria diagnosis in sub-Saharan Africa but the utility of the most commonly used histidine-rich protein 2 (HRP2) antigen-based tests is limited in high tran

Lynch E Jensen TO Assao B Chihana M Turuho T Nyehangane D Manyok JB Pasquale H Khim N Witkowski B Coldiron ME
Malaria journal 2022 Sep 09; 21(1); . doi: 10.1186/s12936-022-04280-w. Epub 2022 09 09
Histidine-rich protein 2 Malaria Plasmodium lactate dehydrogenase Rapid diagnostic test South Sudan

Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis.


BACKGROUND: BCG vaccines are given to more than 100 million children every year, but there is considerable debate regarding the effectiveness of BCG vaccination in preventing tuberculosis and death, particularly among older children an

Martinez L Cords O Liu Q Acuna-Villaorduna C Bonnet M Fox GJ Carvalho ACC Chan PC Croda J Hill PC Lopez-Varela E Donkor S Fielding K Graham SM Espinal MA Kampmann B Reingold A Huerga H Villalba JA Grandjean L Sotgiu G Egere U Singh S Zhu L Lienhardt C Denholm JT Seddon JA Whalen CC García-Basteiro AL Triasih R Chen C Singh J Huang LM Sharma S Hannoun D Del Corral H Mandalakas AM Malone LL Ling DL Kritski A Stein CM Vashishtha R Boulahbal F Fang CT Boom WH Netto EM Lemos AC Hesseling AC Kay A Jones-López EC Horsburgh CR Lange C Andrews JR
The Lancet. Global health 2022 Sep ; 10(9); . doi: 10.1016/S2214-109X(22)00283-2. Epub 2022 08 15

Validation of Three MicroScan Antimicrobial Susceptibility Testing Plates Designed for Low-Resource Settings.


Easy and robust antimicrobial susceptibility testing (AST) methods are essential in clinical bacteriology laboratories (CBL) in low-resource settings (LRS).

Ronat JB Oueslati S Natale A Kesteman T Elamin W Langendorf C Hardy L Vandenberg O Naas T
Diagnostics (Basel, Switzerland) 2022 Aug 30; 12(9); . doi: 10.3390/diagnostics12092106. Epub 2022 08 30
MicroScan antibiotic susceptibility testing clinical bacteriology low-resource settings

Cost-effectiveness of routine versus indicated antibiotic therapy in the management of severe wasting in children.


BACKGROUND: In the outpatient management of severe wasting, routine antibiotic therapy is recommended for all children upon admission regardless of whether clinical signs of infection are present.

Isanaka S Tang K Berthé F Grais RF Pandya A
Cost effectiveness and resource allocation : C/E 2022 Aug 03; 20(1); . doi: 10.1186/s12962-022-00374-z. Epub 2022 08 03
Antibiotic therapy Cost-effectiveness Niger Severe acute malnutrition Wasting

Viral suppression and HIV-1 drug resistance 1 year after pragmatic transitioning to dolutegravir first-line therapy in Malawi: a prospective cohort study.


BACKGROUND: Many countries are now replacing non-nucleoside reverse transcriptase inhibitor (NNRTI)-based first-line antiretroviral therapy (ART) with a regimen containing tenofovir disoproxil fumarate, lamivudine, and dolutegravir (TL

Schramm B Temfack E Descamps D Nicholas S Peytavin G Bitilinyu-Bangoh JE Storto A Lê MP Abdi B Ousley J Kalua T Calvez V Jahn A Marcelin AG Szumilin E
The lancet. HIV 2022 Aug ; 9(8); . doi: 10.1016/S2352-3018(22)00136-9. Epub 2022 07 29