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Evaluating newly approved drugs for multidrug-resistant tuberculosis (endTB): study protocol for an adaptive, multi-country randomized controlled trial.


BACKGROUND: Treatment of multidrug- and rifampin-resistant tuberculosis (MDR/RR-TB) is expensive, labour-intensive, and associated with substantial adverse events and poor outcomes.

Guglielmetti L Ardizzoni E Atger M Baudin E Berikova E Bonnet M Chang E Cloez S Coit JM Cox V de Jong BC Delifer C Do JM Tozzi DDS Ducher V Ferlazzo G Gouillou M Khan A Khan U Lachenal N LaHood AN Lecca L Mazmanian M McIlleron H Moschioni M O'Brien K Okunbor O Oyewusi L Panda S Patil SB Phillips PPJ Pichon L Rupasinghe P Rich ML Saluhuddin N Seung KJ Tamirat M Trippa L Cellamare M Velásquez GE Wasserman S Zimetbaum PJ Varaine F Mitnick CD
Trials 2021 Sep 25; 22(1); 651. doi: 10.1186/s13063-021-05491-3. Epub 2021 09 25
Bayesian adaptive randomization Bedaquiline Clofazimine Delamanid Fluoroquinolone Linezolid MDR-TB Non-inferiority Pyrazinamide Rifampicin-resistant tuberculosis Rifampin-resistant tuberculosis Treatment shortening

Exploring the relationships between wasting and stunting among a cohort of children under two years of age in Niger.


BACKGROUND: Wasting and stunting, physical growth manifestations of child undernutrition, have historically been considered separately with distinct interventions at the program, policy, and financing levels despite similar risk factor

Kohlmann K Sudfeld CR Garba S Guindo O Grais RF Isanaka S
BMC public health 2021 Sep 21; 21(1); 1713. doi: 10.1186/s12889-021-11689-6. Epub 2021 09 21
Child Concurrence Growth Niger Stunting Undernutrition Wasting

The relationship between wasting and stunting in young children: A systematic review.


In 2014, the Emergency Nutrition Network published a report on the relationship between wasting and stunting.

Thurstans S Sessions N Dolan C Sadler K Cichon B Isanaka S Roberfroid D Stobaugh H Webb P Khara T
Maternal & child nutrition 2021 Sep 05; e13246. doi: 10.1111/mcn.13246. Epub 2021 09 05
child growth infectious disease international child health nutrition malnutrition stunting wasting

An exploratory qualitative study of caregivers' knowledge, perceptions and practices related to hospital hygiene in rural Niger.


Background: The risk of healthcare-associated infections is exacerbated by poor hygiene practices in health care facilities and can contribute to increased patient morbidity and mortality.

Marquer C Guindo O Mahamadou I Job E Rattigan SM Langendorf C Grais RF Isanaka S
Infection prevention in practice 2021 Sep ; 3(3); 100160. doi: 10.1016/j.infpip.2021.100160. Epub 2021 07 03
Caregiver knowledge Hospital Hygiene Niger Qualitative Severe acute malnutrition

Etiology and Incidence of Moderate-to-Severe Diarrhea in Young Children in Niger.


BACKGROUND: High-resolution data on the etiology of childhood diarrhea in countries with the highest burden and mortality remain sparse and are needed to inform burden estimates and prioritize interventions.

Platts-Mills JA Houpt ER Liu J Zhang J Guindo O Sayinzoga-Makombe N McMurry TL Elwood S Langendorf C Grais RF Isanaka S
Journal of the Pediatric Infectious Diseases Society 2021 Sep 01; doi: 10.1093/jpids/piab080. Epub 2021 09 01


children diarrhea rotavirus

Pneumococcal Meningitis Outbreaks in Africa, 2000-2018: Systematic Literature Review and Meningitis Surveillance Database Analyses.


BACKGROUND: The meningitis belt of sub-Saharan Africa has traditionally experienced large outbreaks of meningitis mainly caused by Neisseria meningitidis.

Franklin K Kwambana-Adams B Lessa FC Soeters HM Cooper L Coldiron ME Mwenda J Antonio M Nakamura T Novak R Cohen AL
The Journal of infectious diseases 2021 Sep 01; 224(Supplement_3); S174-S183. doi: 10.1093/infdis/jiab105. Epub 2021 09 01
Africa Streptococcus pneumoniae meningitis outbreak pneumococcus
Burns R Venables E Odhoch L Kocholla L Wanjala S Mucinya G Bossard C Wringe A
AIDS care 2021 Aug 26; 1-8. doi: 10.1080/09540121.2021.1966697. Epub 2021 08 26
Advanced HIV Democratic Republic of the Congo Kenya hospitalised patients people living with HIV

Investigating the link between Alpha-1 Antitrypsin Deficiency and Abdominal Aortic Aneurysms.


OBJECTIVES: Alpha-1-Antitrypsin (AAT) is one of the major plasmatic protease inhibitors. In the last decade, an association between Alpha-1-Antitrypsin Deficiency (AATD) and Abdominal Aortic Aneurysms (AAA) has been hypothesized.

Pini L Peroni M Zanotti C Pini A Bossoni E Giordani J Bargagli E Perger E Ferrarotti I Vizzardi E Tiberio L Bonardelli S Tantucci C
Annals of vascular surgery 2021 Aug 26; doi: 10.1016/j.avsg.2021.05.064. Epub 2021 08 26
Abdominal Aortic Aneurysm Allelic Variants Alpha-1 Antitrypsin Deficiency Genotyping Vascular Disease

Development of a dosing-adjustment tool for fluoroquinolones in osteoarticular infections: The Fluo-pop study.


Fluoroquinolones efficacy depend on both the drug exposure and the level of drug resistance of the bacteria responsible for the infection.

Lemaitre F Fily F Foulquier JB Revest M Jullien V Petitcollin A Tattevin P Tron C Polard JL Verdier MC Comets E Huten D Arvieux C Bellissant E Laviolle B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug 19; 142 112053. doi: 10.1016/j.biopha.2021.112053. Epub 2021 08 19
Bone infection Joint infection Modeling Ofloxacin Pharmacokinetics