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Cost and cost-effectiveness of a simplified treatment model with direct-acting antivirals for chronic hepatitis C in Cambodia.


BACKGROUND & AIMS: In 2016, Médecins Sans Frontières established the first general population Hepatitis C virus (HCV) screening and treatment site in Cambodia, offering free direct acting antiviral (DAA) treatment.

Auteurs: Walker JG Mafirakureva N Iwamoto M Campbell L Kim CS Hastings RA Doussett JP Le Paih M Balkan S Marquardt T Maman D Loarec A Coast J Vickerman P
Référence de l'article: Liver international : official journal of the International Association for the Study of the Liver 2020 May 31; (); Array. doi: 10.1111/liv.14550. Epub 2020 05 31
Markov process cost effectiveness direct acting antiviral treatment healthcare costs hepatitis C low income population treatment costs

Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward.


Serological testing for SARS-CoV-2 has enormous potential to contribute to COVID-19 pandemic response efforts. However, the required performance characteristics of antibody tests will critically depend on the use case (individual-level vs.

Auteurs: Bryant JE Azman AS Ferrari MJ Arnold BF Boni MF Boum Y Hayford K Luquero FJ Mina MJ Rodriguez-Barraquer I Wu JT Wade D Vernet G Leung DT
Référence de l'article: Science immunology 2020 05 19; 5(47); Array. doi: 10.1126/sciimmunol.abc6347. Epub 2020 05 22

High sustained viral response rate in patients with hepatitis C using generic sofosbuvir and daclatasvir in Phnom Penh, Cambodia.


Safe and efficacious pan-genotypic direct-acting antiviral (DAA) regimens, such as sofosbuvir and daclatasvir (SOF+DCV)facilitate simplified models of care for hepatitis C virus (HCV).

Auteurs: Zhang M O'Keefe D Iwamoto M Sann K Kien A Hang V Brucker C Jolivet P Ly S Chhit D Balkan S Marquardt T Le Paih M Dousset JP
Référence de l'article: Journal of viral hepatitis 2020 May 02; (); Array. doi: 10.1111/jvh.13311. Epub 2020 05 02
Cambodia Daclatasvir Hepatitis C SVR12 Sofosbuvir

Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis.


BACKGROUND: The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant liver stages.

Auteurs: Pfeffer DA Ley B Howes RE Adu P Alam MS Bansil P Boum Y Brito M Charoenkwan P Clements A Cui L Deng Z Egesie OJ Espino FE von Fricken ME Hamid MMA He Y Henriques G Khan WA Khim N Kim S Lacerda M Lon C Mekuria AH Menard D Monteiro W Nosten F Oo NN Pal S Palasuwan D Parikh S Pitaloka Pasaribu A Poespoprodjo JR Price DJ Roca-Feltrer A Roh ME Saunders DL Spring MD Sutanto I Ley-Thriemer K Weppelmann TA von Seidlein L Satyagraha AW Bancone G Domingo GJ Price RN
Référence de l'article: PLoS medicine 2020 May ; 17(5); e1003084. doi: 10.1371/journal.pmed.1003084. Epub 2020 05 14

Suspected paracetamol overdose in Monrovia, Liberia: a matched case-control study.


BACKGROUND: A cluster of cases of unexplained multi-organ failure was reported in children at Bardnesville Junction Hospital (BJH), Monrovia, Liberia.

Auteurs: Haidar MK Vogt F Takahashi K Henaff F Umphrey L Morton N Bawo L Kerkula J Ferner R Porten K Baud FJ
Référence de l'article: BMC pediatrics 2020 Mar 30; 20(1); 139. doi: 10.1186/s12887-020-2008-3. Epub 2020 03 30
Liberia Liver insufficiency Paediatrics Paracetamol

The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis.


BACKGROUND: Tens of millions of children are exposed to Mycobacterium tuberculosis globally every year; however, there are no contemporary estimates of the risk of developing tuberculosis in exposed children.

Auteurs: Martinez L Cords O Horsburgh CR Andrews JR
Référence de l'article: Lancet (London, England) 2020 Mar 21; 395(10228); 973-984. doi: 10.1016/S0140-6736(20)30166-5. Epub 2020 03 22