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Prioritising pathogens for the management of severe febrile patients to improve clinical care in low- and middle-income countries.


BACKGROUND: Severe febrile illness without a known source (SFWS) is a challenge for clinicians when deciding how to manage a patient, particularly given the wide spectrum of potential aetiologies that contribute to fever.

Auteurs: Osborn J Roberts T Guillen E Bernal O Roddy P Ongarello S Sprecher A Page AL Ribeiro I Piriou E Tamrat A de la Tour R Rao VB Flevaud L Jensen T McIver L Kelly C Dittrich S
Référence de l'article: BMC infectious diseases 2020 Feb 10; 20(1); 117. doi: 10.1186/s12879-020-4834-1. Epub 2020 02 10
Diagnostics Disease prioritization Fever causing pathogens Severe febrile illness

Evaluation of the stability of measles vaccine out of the cold chain under extended controlled temperature conditions.


Measles outbreaks occur periodically in remote and difficult to reach areas in countries such as the Democratic Republic of Congo.

Auteurs: Juan-Giner A Alsalhani A Panunzi I Lambert V Van Herp M Gairola S
Référence de l'article: Vaccine 2020 Feb 08; (); Array. doi: 10.1016/j.vaccine.2020.02.005. Epub 2020 02 08
Controlled temperature chain Extended controlled temperature conditions Measles Out of the cold chain Outbreak response

High cholera vaccination coverage following emergency campaign in Haiti: Results from a cluster survey in three rural Communes in the South Department, 2017.


Oral cholera vaccine (OCV) has increasingly been used as an outbreak control measure, but vaccine shortages limit its application.

Auteurs: Sharp A Blake A Backx J Panunzi I Barrais R Nackers F Luquero F Deslouches YG Cohuet S
Référence de l'article: PLoS neglected tropical diseases 2020 Jan 31; 14(1); e0007967. doi: 10.1371/journal.pntd.0007967. Epub 2020 01 31

Effect of high-dose rifampicin on efavirenz pharmacokinetics: drug-drug interaction randomized trial.


BACKGROUND: High-dose rifampicin is considered to shorten anti-TB treatment duration but its effect on antiretroviral metabolism is unknown.

Auteurs: Atwine D Baudin E Gelé T Muyindike W Mworozi K Kyohairwe R Kananura K Orikiriza P Nyehangane D K T Nanjebe D Furlan V Verstuyft C Barrail-Tran A Taburet AM Bonnet M
Référence de l'article: The Journal of antimicrobial chemotherapy 2020 Jan 30; (); Array. doi: 10.1093/jac/dkz557. Epub 2020 01 30

Evaluating lactate prognostic value in children suspected of acetaminophen-induced liver failure in Liberia.


BACKGROUND: The prognostic significance of hyperlactatemia in young children with liver injury suspected to be attributed to repeated supratherapeutic doses of acetaminophen remain understudied.

Auteurs: Haidar MK Morton N Roederer T Mayronne S Bawo L Kerkula J Porten K Baud FJ
Référence de l'article: Pediatric research 2020 Jan 29; (); Array. doi: 10.1038/s41390-020-0783-z. Epub 2020 01 29

Systematic, Point-of-Care Urine Lipoarabinomannan (Alere TB-LAM) Assay for Diagnosing Tuberculosis in Severely Immunocompromised HIV-Positive Ambulatory Patients.


Point-of-care urine-lipoarabinomannan (LAM) Alere Determine TB-LAM assay has shown utility diagnosing tuberculosis (TB) in HIV-positive, severely immunocompromised, TB-symptomatic patients.

Auteurs: Huerga H Cossa L Manhiça I Bastard M Telnov A Molfino L Sanchez-Padilla E
Référence de l'article: The American journal of tropical medicine and hygiene 2020 Jan 20; (); Array. doi: 10.4269/ajtmh.19-0493. Epub 2020 01 20

Extended Follow-up From a Randomized Clinical Trial of Routine Amoxicillin in the Treatment of Uncomplicated Severe Acute Malnutrition in Niger.


Evidence to support current guidelines recommending routine antibiotic use in the outpatient management of uncomplicated severe acute malnutrition (SAM) is limited and based largely on data from historical inpatient settings.

Auteurs: Isanaka S Grantz KH Berthé F Schaefer M Adehossi E Grais RF
Référence de l'article: JAMA pediatrics 2020 Jan 13; (); Array. doi: 10.1001/jamapediatrics.2019.5189. Epub 2020 01 13
Nutrition Amoxicillin

Should Urine-LAM Tests Be Used in TB Symptomatic HIV-Positive Patients When No CD4 Count Is Available? A Prospective Observational Cohort Study From Malawi.


BACKGROUND: Current eligibility criteria for urine lateral-flow lipoarabinomannan assay (LF-LAM) in ambulatory, HIV-positive patients rely on the CD4 count.

Auteurs: Huerga H Rucker SCM Bastard M Dimba A Kamba C Amoros I Szumilin E
Référence de l'article: Journal of acquired immune deficiency syndromes (1999) 2020 01 01; 83(1); 24-30. doi: 10.1097/QAI.0000000000002206. Epub 2020 07 06

Feasibility of engaging caregivers in at-home surveillance of children with uncomplicated severe acute malnutrition.


Many factors can contribute to low coverage of treatment for severe acute malnutrition (SAM), and a limited number of health facilities and trained personnel can constrain the number of children that receive treatment.

Auteurs: Isanaka S Berthé F Nackers F Tang K Hanson KE Grais RF
Référence de l'article: Maternal & child nutrition 2020 01 ; 16(1); e12876. doi: 10.1111/mcn.12876. Epub 2019 08 09
MUAC Niger clinical surveillance community-based management of acute malnutrition (CMAM) severe acute malnutrition task shifting

Clinical diagnostic evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria in an area receiving seasonal malaria chemoprevention in Niger.


BACKGROUND: Rapid diagnostic tests (RDT) for malaria are common, but their performance varies. Tests using histidine-rich protein 2 (HRP2) antigen are most common, and many have high sensitivity.

Auteurs: Coldiron ME Assao B Langendorf C Sayinzoga-Makombe N Ciglenecki I de la Tour R Piriou E Yarima Bako M Mumina A Guindo O Page AL Grais RF
Référence de l'article: Malaria journal 2019 Dec 26; 18(1); 443. doi: 10.1186/s12936-019-3079-1. Epub 2019 12 26
Histidine-rich protein 2 Malaria Niger Plasmodium lactate dehydrogenase Rapid diagnostic test