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The impact of control strategies and behavioural changes on the elimination of Ebola from Lofa County, Liberia.


The Ebola epidemic in West Africa was stopped by an enormous concerted effort of local communities and national and international organizations.

Auteurs: Funk S Ciglenecki I Tiffany A Gignoux E Camacho A Eggo RM Kucharski AJ Edmunds WJ Bolongei J Azuma P Clement P Alpha TS Sterk E Telfer B Engel G Parker LA Suzuki M Heijenberg N Reeder B
Référence de l'article: Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2017 May 26; 372(1721); Array. doi: 10.1098/rstb.2016.0302. Epub 2017 12 18
behavioural changes community engagement infectious disease dynamics interventions isolation mathematical model

Intermittent preventive treatment for malaria among children in a refugee camp in Northern Uganda: lessons learned.


Northern Uganda hosts a large population of refugees from South Sudan, and malaria is one of the major health problems in the area.

Auteurs: Coldiron ME Lasry E Bouhenia M Das D Okui P Nyehangane D Mwanga J Langendorf C Elder G Salumu L Grais RF
Référence de l'article: Malaria journal 2017 05 23; 16(1); 218. doi: 10.1186/s12936-017-1869-x. Epub 2017 05 23
Anti-malarials Artemisinin Malaria Quinolines Refugee South Sudan Uganda

Estimating HIV Incidence Using a Cross-Sectional Survey: Comparison of Three Approaches in a Hyperendemic Setting, Ndhiwa Subcounty, Kenya, 2012.


OBJECTIVES: Estimating HIV incidence is critical for identifying groups at risk for HIV infection, planning and targeting interventions, and evaluating these interventions over time.

Auteurs: Blaizot S Kim AA Zeh C Riche B Maman D De Cock KM Etard JF Ecochard R
Référence de l'article: AIDS research and human retroviruses 2017 05 ; 33(5); 472-481. doi: 10.1089/AID.2016.0123. Epub 2016 12 13
Africa HIV/AIDS epidemic incidence incidence assay incidence estimation statistical model
Auteurs: Ciglenecki I Azman AS Rumunu J Cabrol JC Luquero FJ
Référence de l'article: The Lancet. Infectious diseases 2017 05 ; 17(5); 480-481. doi: 10.1016/S1473-3099(17)30184-6. Epub 2018 09 14

Outpatient treatment of severe acute malnutrition: response to treatment with a reduced schedule of therapeutic food distribution.


Community-based management of severe acute malnutrition (SAM) has been shown to be safe and cost-effective, but program coverage remains low.

Auteurs: Isanaka S Kodish SR Berthé F Alley I Nackers F Hanson KE Grais RF
Référence de l'article: The American journal of clinical nutrition 2017 05 ; 105(5); 1191-1197. doi: 10.3945/ajcn.116.148064. Epub 2017 04 12
CMAM RUTF SAM community-based management of acute malnutrition household utilization ready-to-use therapeutic food severe acute malnutrition treatment response

Improving the Specificity of Plasmodium falciparum Malaria Diagnosis in High-Transmission Settings with a Two-Step Rapid Diagnostic Test and Microscopy Algorithm.


Poor specificity may negatively impact rapid diagnostic test (RDT)-based diagnostic strategies for malaria.

Auteurs: Murungi M Fulton T Reyes R Matte M Ntaro M Mulogo E Nyehangane D Juliano JJ Siedner MJ Boum Y Boyce RM
Référence de l'article: Journal of clinical microbiology 2017 05 ; 55(5); 1540-1549. doi: 10.1128/JCM.00130-17. Epub 2017 03 08
Plasmodium falciparum antigen specificity diagnostics epidemiology malaria rapid tests

El Niño and the shifting geography of cholera in Africa.


The El Niño Southern Oscillation (ENSO) and other climate patterns can have profound impacts on the occurrence of infectious diseases ranging from dengue to cholera.

Auteurs: Moore SM Azman AS Zaitchik BF Mintz ED Brunkard J Legros D Hill A McKay H Luquero FJ Olson D Lessler J
Référence de l'article: Proceedings of the National Academy of Sciences of the United States of America 2017 04 25; 114(17); 4436-4441. doi: 10.1073/pnas.1617218114. Epub 2017 04 10
Bayesian mapping El Niño Southern Oscillation cholera climate and health disease mapping

Predictors of delayed culture conversion among Ugandan patients.


BACKGROUND: Estimates of month-2 culture conversion, a proxy indicator of tuberculosis (TB) treatment efficacy in phase-2 trials can vary by culture-type and geographically with lower rates reported among African sites.

Auteurs: Atwine D Orikiriza P Taremwa I Ayebare A Logoose S Mwanga-Amumpaire J Jindani A Bonnet M
Référence de l'article: BMC infectious diseases 2017 04 24; 17(1); 299. doi: 10.1186/s12879-017-2335-7. Epub 2017 04 24
Delayed culture conversion Efficacy HIV-negative TB patients Time-to-detection Treatment failure

Effect of previous treatment and sputum quality on diagnostic accuracy of Xpert MTB/RIF.


SETTING: In early studies, Xpert® MTB/RIF accurately detected culture-proven pulmonary tuberculosis (TB). Recent reports have, however, found a lower than expected specificity in previously treated TB patients.

Auteurs: Acuña-Villaorduña C Orikiriza P Nyehangane D White LF Mwanga-Amumpaire J Kim S Bonnet M Fennelly KP Boum Y Jones-López EC
Référence de l'article: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2017 04 01; 21(4); 389-397. doi: 10.5588/ijtld.16.0785. Epub 2018 03 01

Different origin and dispersal of sulfadoxine-resistant Plasmodium falciparum haplotypes between Eastern Africa and Democratic Republic of Congo.


Sulfadoxine/pyrimethamine (SP) is still used for malaria control in sub-Saharan Africa; however, widespread resistance is a major concern.

Auteurs: Baraka V Delgado-Ratto C Nag S Ishengoma DS Madebe RA Mavoko HM Nabasumba C Lutumba P Alifrangis M Van Geertruyden JP
Référence de l'article: International journal of antimicrobial agents 2017 Apr ; 49(4); 456-464. doi: 10.1016/j.ijantimicag.2016.12.007. Epub 2017 02 22
Drug resistance Microsatellites Molecular evolution Pfdhps Plasmodium falciparum Sulfadoxine