Implementation research: reactive mass vaccination with single-dose oral cholera vaccine, Zambia.


Objective: To describe the implementation and feasibility of an innovative mass vaccination strategy - based on single-dose oral cholera vaccine - to curb a cholera epidemic in a large urban setting.

Authors: Poncin M Zulu G Voute C Ferreras E Muleya CM Malama K Pezzoli L Mufunda J Robert H Uzzeni F Luquero FJ Chizema E Ciglenecki I
Journal Reference: Bulletin of the World Health Organization 2018 Feb 01; 96(2); 86-93. doi: 10.2471/BLT.16.189241. Epub 2017 10 19

Inequality in outcomes for adolescents living with perinatally acquired HIV in sub-Saharan Africa: a Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Cohort Collaboration analysis.


INTRODUCTION: Eighty percent of adolescents living with perinatally and behaviourally acquired HIV live in sub-Saharan Africa (SSA), a continent with marked economic inequality.

Journal Reference: Journal of the International AIDS Society 2018 Feb ; 21 Suppl 1(); Array. doi: 10.1002/jia2.25044. Epub 2019 02 16

Sustainable Development Goals adolescent perinatally acquired sub-Saharan Africa

The potential impact of case-area targeted interventions in response to cholera outbreaks: A modeling study.


BACKGROUND: Cholera prevention and control interventions targeted to neighbors of cholera cases (case-area targeted interventions [CATIs]), including improved water, sanitation, and hygiene, oral cholera vaccine (OCV), and prophylactic

Authors: Finger F Bertuzzo E Luquero FJ Naibei N Touré B Allan M Porten K Lessler J Rinaldo A Azman AS
Journal Reference: PLoS medicine 2018 02 ; 15(2); e1002509. doi: 10.1371/journal.pmed.1002509. Epub 2018 02 27

High Prevalence of or Enteroinvasive Carriage among Residents of an Internally Displaced Persons Camp in South Sudan.


Displaced persons living in camps are at an increased risk of diarrheal diseases. Subclinical carriage of pathogens may contribute to the spread of disease, especially for microbes that require a low infectious dose.

Authors: Bliss J Bouhenia M Hale P Couturier BA Iyer AS Rumunu J Martin S Wamala JF Abubakar A Sack DA Luquero FJ Couturier MR Azman AS Leung DT
Journal Reference: The American journal of tropical medicine and hygiene 2018 02 ; 98(2); 595-597. doi: 10.4269/ajtmh.17-0339. Epub 2017 11 30

Treatment outcomes and tolerability of the revised WHO anti-tuberculosis drug dosages for children.


BACKGROUND: In 2010, the World Health Organization (WHO) revised the paediatric dosages of anti-tuberculosis drugs, increasing rifampicin to 15 mg/kg, isoniazid to 10 mg/kg and pyrazinamide to 35 mg/kg.

Authors: Nansumba M Kumbakumba E Orikiriza P Bastard M Mwanga JA Boum Y de Beaudrap P Bonnet M
Journal Reference: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2018 02 01; 22(2); 151-157. doi: 10.5588/ijtld.17.0535. Epub 2017 12 20

Effectiveness of biologic and non-biologic antirheumatic drugs on anaemia markers in 153,788 patients with rheumatoid arthritis: New evidence from real-world data.


BACKGROUND: To evaluate the impact of treatment with disease-modifying antirheumatic drugs (DMARDs), including IL-6 receptor inhibitor tocilizumab (TCZ), on anaemia markers in patients with rheumatoid arthritis.

Authors: Paul SK Montvida O Best JH Gale S Pethoe-Schramm A Sarsour K
Journal Reference: Seminars in arthritis and rheumatism 2018 02 ; 47(4); 478-484. doi: 10.1016/j.semarthrit.2017.08.001. Epub 2017 08 03
Change in anaemia markers Comparison of biologic and non-biologic DMARDs IL-6 receptor inhibitor Real-world data Tocilizumab

Efficacy of artesunate-amodiaquine, dihydroartemisinin-piperaquine and artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Maradi, Niger.


BACKGROUND: Malaria endemic countries need to assess efficacy of anti-malarial treatments on a regular basis.

Authors: Grandesso F Guindo O Woi Messe L Makarimi R Traore A Dama S Laminou IM Rigal J de Smet M Ouwe Missi Oukem-Boyer O Doumbo OK Djimdé A Etard JF
Journal Reference: Malaria journal 2018 Jan 25; 17(1); 52. doi: 10.1186/s12936-018-2200-1. Epub 2018 01 25
Antimalarial Artemisinin Efficacy Malaria Niger Parasite clearance Resistance

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa.


BACKGROUND: In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-6-phosphate

Authors: Taylor WR Naw HK Maitland K Williams TN Kapulu M D'Alessandro U Berkley JA Bejon P Okebe J Achan J Amambua AN Affara M Nwakanma D van Geertruyden JP Mavoko M Lutumba P Matangila J Brasseur P Piola P Randremanana R Lasry E Fanello C Onyamboko M Schramm B Yah Z Jones J Fairhurst RM Diakite M Malenga G Molyneux M Rwagacondo C Obonyo C Gadisa E Aseffa A Loolpapit M Henry MC Dorsey G John C Sirima SB Barnes KI Kremsner P Day NP White NJ Mukaka M
Journal Reference: BMC medicine 2018 01 18; 16(1); 11. doi: 10.1186/s12916-017-0990-6. Epub 2018 01 18
Age-based dosing Malaria Plasmodium falciparum Primaquine Transmission blocking

High rates of hypertension, diabetes, elevated low-density lipoprotein cholesterol, and cardiovascular disease risk factors in HIV-infected patients in Malawi.


OBJECTIVES: Data on cardiovascular disease risks among HIV-infected patients taking antiretroviral therapy (ART) over long periods of time are lacking in Sub-Saharan Africa.

Authors: Mathabire Rücker SC Tayea A Bitilinyu-Bangoh J Bermúdez-Aza EH Salumu L Quiles IA Szumilin E Chirwa Z Rick F Maman D
Journal Reference: AIDS (London, England) 2018 Jan 14; 32(2); 253-260. doi: 10.1097/QAD.0000000000001700. Epub 2018 07 16

Detection of Plasmodium Species by High-Resolution Melt Analysis of DNA from Blood Smears Acquired in Southwestern Uganda.


Microscopic diagnosis of malaria using Giemsa-stained blood smears is the standard of care in resource-limited settings.

Authors: Kassaza K Operario DJ Nyehangane D Coffey KC Namugosa M Turkheimer L Ojuka P Orikiriza P Mwanga-Amumpaire J Byarugaba F Bazira J Guler JL Moore CC Boum Y
Journal Reference: Journal of clinical microbiology 2018 01 ; 56(1); Array. doi: 10.1128/JCM.01060-17. Epub 2017 12 26
PCR diagnostics high-resolution melting malaria