Nutrition

Thursday 1 July 2021 - Updated on Tuesday 26 July 2022
Find out about current projects on malnutrition.

Effectiveness of a microbiota-targeted food to promote programmatic and sustainable nutritional recovery in children with uncomplicated acute malnutrition

Context 

  • Frequent relapses
  • Gut microbiota could be a target to decrease the risk of relapse
  • Proof of concept in Bangladesh (Chen et al, 2021): Promising results in limited sample
  • Evidence needed from larger randomized trials to show efficacy of an ACM on cure in children with SAM and MAM in other settings.

 

Primary objective

To evaluate the efficacy of a microbiota-targeted food (MFA) in terms of recovery in the program within 12 weeks and sustained recovery within 24 weeks of admission in children with uncomplicated acute malnutrition in Niger compared with standard ready-to-use therapeutic foods (RTTP) for SAM and standard supplementary ready-to-use foods (SRTP) for AMM.

 

Secondary objectives

  • Efficacy in terms of nonresponse and program dropout
  • Safety in terms of hospitalization, mortality, and serious adverse events
  • Effect on child anthropometry and neurocognitive development
  • Acceptability and use of the products in the home
  • Cost-effectiveness

 

 

Methodology

Individually randomized controlled trial stratified by severity of acute malnutrition.

  • 2 MAS arms: ACM vs ATPE (Plumpy'nut)
  • 2 MAS arms: ACM vs ASPE (Plumpy'sup)

 

Who’s involved besides MSF?

 

Country

Niger

Tentative End date

December 2023

Our Role

coordination 

 

For more information, contact

Référence profils
Photo
S. Isanaka
Sheila Isanaka
Titre du poste
Epidemiologist
Description courte
specialist in the study of severe acute malnutrition (SAM).