Carriage prevalence and serotype distribution of Streptococcus pneumoniae prior to 10-valent pneumococcal vaccine introduction: A population-based cross-sectional study in South Western Uganda, 2014.


BACKGROUND: Information on Streptococcus pneumoniae nasopharyngeal (NP) carriage before the pneumococcal conjugate vaccine (PCV) introduction is essential to monitor impact.

Authors: Nackers F Cohuet S le Polain de Waroux O Langendorf C Nyehangane D Ndazima D Nanjebe D Karani A Tumwesigye E Mwanga-Amumpaire J Scott JAG Grais RF
Journal Reference: Vaccine 2017 09 18; 35(39); 5271-5277. doi: 10.1016/j.vaccine.2017.07.081. Epub 2017 08 04
Adult Children Nasopharyngeal carriage Pneumococcal conjugate vaccine Pneumococcal serotypes Streptococcus pneumoniae Uganda

Prevalence of antibodies to Brucella species in commercial raw bovine milk in Southwestern Uganda.


OBJECTIVES: The purpose and objective of this research was to explore the prevalence of antibodies against Brucella species in raw milk samples collected in Southwestern Uganda, one of the biggest milk producing regions in the Country.

Authors: Kamwine M Orikiriza P Taseera K Iramiot JS Ojuka P Ikiriza S Atwebembeire J Otieno D Tweshengyereze S Mwanga-Amumpaire J Bazira J Boum Y
Journal Reference: BMC research notes 2017 Sep 08; 10(1); 215. doi: 10.1186/s13104-017-2537-5. Epub 2017 09 08
Brucellosis Diagnosis Indirect ELISA Milk ring test

A guide to aid the selection of diagnostic tests.


In recent years, a wide range of diagnostic tests has become available for use in resource-constrained settings. Accordingly, a huge number of guidelines, performance evaluations and implementation reports have been produced.

Authors: Kosack CS Page AL Klatser PR
Journal Reference: Bulletin of the World Health Organization 2017 Sep 01; 95(9); 639-645. doi: 10.2471/BLT.16.187468. Epub 2017 06 26

Adherence, tolerability, and outcome after 36 months of isoniazid-preventive therapy in 2 rural clinics of Swaziland: A prospective observational feasibility study.


Although efficacy of 36 months isoniazid preventive therapy (IPT) among HIV-positive individuals has been proven in trial settings, outcome, tolerance, and adherence have rarely been evaluated in real-life settings.This is a prospective observational c

Authors: Mueller Y Mpala Q Kerschberger B Rusch B Mchunu G Mazibuko S Bonnet M
Journal Reference: Medicine 2017 Sep ; 96(35); e7740. doi: 10.1097/MD.0000000000007740. Epub 2017 09 11

Prospective cohort study of the feasibility and yield of household child tuberculosis contact screening in Uganda.


SETTING: Screening and isoniazid preventive therapy (IPT) of child contacts of tuberculosis (TB) patients is poorly implemented in resource-limited countries, in part due to difficulties in TB diagnosis in children.

Authors: Bonnet M Kyakwera C Kyomugasho N Atwine D Mugabe F Nansumba M Ii YB Mwanga-Amumpaire J Kiwanuka J
Journal Reference: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2017 08 01; 21(8); 862-868. doi: 10.5588/ijtld.16.0889. Epub 2018 04 26

Combined interventions to reduce HIV incidence in KwaZulu-Natal: a modelling study.


BACKGROUND: Combined prevention interventions, including early antiretroviral therapy initiation, may substantially reduce HIV incidence in hyperendemic settings.

Authors: Blaizot S Huerga H Riche B Ellman T Shroufi A Etard JF Ecochard R
Journal Reference: BMC infectious diseases 2017 07 26; 17(1); 522. doi: 10.1186/s12879-017-2612-5. Epub 2017 07 26
Antiretroviral therapy HIV Male circumcision Mathematical models Pre-exposure prophylaxis South Africa
Authors: Isanaka S Djibo A Grais RF
Journal Reference: The New England journal of medicine 2017 07 20; 377(3); 302. doi: 10.1056/NEJMc1705793. Epub 2017 07 24

HIV misdiagnosis in sub-Saharan Africa: performance of diagnostic algorithms at six testing sites.


INTRODUCTION: We evaluated the diagnostic accuracy of HIV testing algorithms at six programmes in five sub-Saharan African countries.

Authors: Kosack CS Shanks L Beelaert G Benson T Savane A Ng'ang'a A Andre B Zahinda JB Fransen K Page AL
Journal Reference: Journal of the International AIDS Society 2017 07 03; 20(1); 21419. doi: 10.7448/IAS.20.1.21419. Epub 2017 11 16
HIV RDT algorithm diagnostic misdiagnosis test

Trends in one-year cumulative incidence of death between 2005 and 2013 among patients initiating antiretroviral therapy in Uganda.


Recent ecological data demonstrate improving outcomes for HIV-infected people in sub-Saharan Africa. Recently, Uganda has experienced a resurgence in HIV incidence and prevalence, but trends in HIV-related deaths have not been well described.

Authors: Bebell LM Siedner MJ Musinguzi N Boum Y Bwana BM Muyindike W Hunt PW Martin JN Bangsberg DR
Journal Reference: International journal of STD & AIDS 2017 07 ; 28(8); 800-807. doi: 10.1177/0956462416671431. Epub 2016 09 20
Africa Death HIV antiretroviral antiretroviral therapy clinical outcomes early mortality