Adherence, tolerability, and outcome after 36 months of isoniazid-preventive therapy in 2 rural clinics of Swaziland: A prospective observational feasibility study.


Although efficacy of 36 months isoniazid preventive therapy (IPT) among HIV-positive individuals has been proven in trial settings, outcome, tolerance, and adherence have rarely been evaluated in real-life settings.This is a prospective observational c

Authors: Mueller Y Mpala Q Kerschberger B Rusch B Mchunu G Mazibuko S Bonnet M
Journal Reference: Medicine 2017 Sep ; 96(35); e7740. doi: 10.1097/MD.0000000000007740. Epub 2017 09 11

Prospective cohort study of the feasibility and yield of household child tuberculosis contact screening in Uganda.


SETTING: Screening and isoniazid preventive therapy (IPT) of child contacts of tuberculosis (TB) patients is poorly implemented in resource-limited countries, in part due to difficulties in TB diagnosis in children.

Authors: Bonnet M Kyakwera C Kyomugasho N Atwine D Mugabe F Nansumba M Ii YB Mwanga-Amumpaire J Kiwanuka J
Journal Reference: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2017 08 01; 21(8); 862-868. doi: 10.5588/ijtld.16.0889. Epub 2018 04 26

Combined interventions to reduce HIV incidence in KwaZulu-Natal: a modelling study.


BACKGROUND: Combined prevention interventions, including early antiretroviral therapy initiation, may substantially reduce HIV incidence in hyperendemic settings.

Authors: Blaizot S Huerga H Riche B Ellman T Shroufi A Etard JF Ecochard R
Journal Reference: BMC infectious diseases 2017 07 26; 17(1); 522. doi: 10.1186/s12879-017-2612-5. Epub 2017 07 26
Antiretroviral therapy HIV Male circumcision Mathematical models Pre-exposure prophylaxis South Africa
Authors: Isanaka S Djibo A Grais RF
Journal Reference: The New England journal of medicine 2017 07 20; 377(3); 302. doi: 10.1056/NEJMc1705793. Epub 2017 07 24

HIV misdiagnosis in sub-Saharan Africa: performance of diagnostic algorithms at six testing sites.


INTRODUCTION: We evaluated the diagnostic accuracy of HIV testing algorithms at six programmes in five sub-Saharan African countries.

Authors: Kosack CS Shanks L Beelaert G Benson T Savane A Ng'ang'a A Andre B Zahinda JB Fransen K Page AL
Journal Reference: Journal of the International AIDS Society 2017 07 03; 20(1); 21419. doi: 10.7448/IAS.20.1.21419. Epub 2017 11 16
HIV RDT algorithm diagnostic misdiagnosis test

Trends in one-year cumulative incidence of death between 2005 and 2013 among patients initiating antiretroviral therapy in Uganda.


Recent ecological data demonstrate improving outcomes for HIV-infected people in sub-Saharan Africa. Recently, Uganda has experienced a resurgence in HIV incidence and prevalence, but trends in HIV-related deaths have not been well described.

Authors: Bebell LM Siedner MJ Musinguzi N Boum Y Bwana BM Muyindike W Hunt PW Martin JN Bangsberg DR
Journal Reference: International journal of STD & AIDS 2017 07 ; 28(8); 800-807. doi: 10.1177/0956462416671431. Epub 2016 09 20
Africa Death HIV antiretroviral antiretroviral therapy clinical outcomes early mortality

Drivers for Rift Valley fever emergence in Mayotte: A Bayesian modelling approach.


Rift Valley fever (RVF) is a major zoonotic and arboviral hemorrhagic fever. The conditions leading to RVF epidemics are still unclear, and the relative role of climatic and anthropogenic factors may vary between ecosystems.

Authors: Métras R Fournié G Dommergues L Camacho A Cavalerie L Mérot P Keeling MJ Cêtre-Sossah C Cardinale E Edmunds WJ
Journal Reference: PLoS neglected tropical diseases 2017 Jul ; 11(7); e0005767. doi: 10.1371/journal.pntd.0005767. Epub 2017 07 21

Ciprofloxacin for contacts of cases of meningococcal meningitis as an epidemic response: study protocol for a cluster-randomized trial.


BACKGROUND: Epidemics of meningococcal meningitis are common in the "African meningitis belt." Current response strategies include reactive vaccination campaigns, which are often organized too late to have maximal impact.

Authors: Coldiron ME Alcoba G Ciglenecki I Hitchings M Djibo A Page AL Langendorf C Grais RF
Journal Reference: Trials 2017 06 24; 18(1); 294. doi: 10.1186/s13063-017-2028-y. Epub 2017 06 24
Ciprofloxacin Drug resistance, bacterial Epidemics Meningitis, meningococcal Neisseria meningitidis Niger