Efficacy of a Low-Cost, Heat-Stable Oral Rotavirus Vaccine in Niger.


BACKGROUND: Each year, rotavirus gastroenteritis is responsible for about 37% of deaths from diarrhea among children younger than 5 years of age worldwide, with a disproportionate effect in sub-Saharan Africa.

Authors: Isanaka S Guindo O Langendorf C Matar Seck A Plikaytis BD Sayinzoga-Makombe N McNeal MM Meyer N Adehossi E Djibo A Jochum B Grais RF
Journal Reference: The New England journal of medicine 2017 03 23; 376(12); 1121-1130. doi: 10.1056/NEJMoa1609462. Epub 2017 04 28

Prevalence and correlates of MRSA and MSSA nasal carriage at a Ugandan regional referral hospital.


Background: Despite increasing antimicrobial resistance globally, data are lacking on prevalence and factors associated with Staphylococcus aureus (SA) and MRSA carriage in resource-limited settings.

Authors: Bebell LM Ayebare A Boum Y Siedner MJ Bazira J Schiff SJ Metlay JP Bangsberg DR Ttendo S Firth PG
Journal Reference: The Journal of antimicrobial chemotherapy 2017 03 01; 72(3); 888-892. doi: 10.1093/jac/dkw472. Epub 2017 10 10

Mortality and clinical outcomes in children treated with antiretroviral therapy in four African vertical programmes during the first decade of paediatric HIV care, 2001-2010.


OBJECTIVE: To assess mortality and clinical outcomes in children treated with antiretroviral therapy (ART) in four African vertical programmes between 2001 and 2010.

Authors: Ben-Farhat J Schramm B Nicolay N Wanjala S Szumilin E Balkan S Pujades-Rodríguez M
Journal Reference: Tropical medicine & international health : TM & IH 2017 03 ; 22(3); 340-350. doi: 10.1111/tmi.12830. Epub 2017 01 26

antiretroviral therapy cohort studies mortality paediatrics treatment failure

Using simulation to aid trial design: Ring-vaccination trials.


BACKGROUND: The 2014-6 West African Ebola epidemic highlights the need for rigorous, rapid clinical trial methods for vaccines.

Authors: Hitchings MD Grais RF Lipsitch M
Journal Reference: PLoS neglected tropical diseases 2017 03 ; 11(3); e0005470. doi: 10.1371/journal.pntd.0005470. Epub 2017 03 22

Outcomes from the first multidrug-resistant tuberculosis programme in Kenya.


SETTING: In March 2006, the first multidrug-resistant tuberculosis (MDR-TB) treatment programme was implemented in Kenya.

OBJECTIVE: To describe patients' treatment outcomes and adverse events.

Authors: Huerga H Bastard M Kamene M Wanjala S Arnold A Oucho N Chikwanha I Varaine F
Journal Reference: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2017 03 01; 21(3); 314-319. doi: 10.5588/ijtld.16.0661. Epub 2018 02 22

Spatial and temporal dynamics of superspreading events in the 2014-2015 West Africa Ebola epidemic.


The unprecedented scale of the Ebola outbreak in Western Africa (2014-2015) has prompted an explosion of efforts to understand the transmission dynamics of the virus and to analyze the performance of possible containment strategies.

Authors: Lau MS Dalziel BD Funk S McClelland A Tiffany A Riley S Metcalf CJ Grenfell BT
Journal Reference: Proceedings of the National Academy of Sciences of the United States of America 2017 02 28; 114(9); 2337-2342. doi: 10.1073/pnas.1614595114. Epub 2017 02 13
Bayesian inference Ebola offspring distribution superspreading

Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!).


BACKGROUND: rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus.

Authors: Henao-Restrepo AM Camacho A Longini IM Watson CH Edmunds WJ Egger M Carroll MW Dean NE Diatta I Doumbia M Draguez B Duraffour S Enwere G Grais R Gunther S Gsell PS Hossmann S Watle SV Kondé MK Kéïta S Kone S Kuisma E Levine MM Mandal S Mauget T Norheim G Riveros X Soumah A Trelle S Vicari AS Røttingen JA Kieny MP
Journal Reference: Lancet (London, England) 2017 02 04; 389(10068); 505-518. doi: 10.1016/S0140-6736(16)32621-6. Epub 2016 12 23

[Trauma and resilience among children 3 to 6 years old in three neighborhoods of Port-au-Prince after the 2010 earthquake in Haiti].


The paper describes an action research for indicative assessment of psychological problems of young children following the 2010 earthquake in Haiti, and the interest of using the Creole version of the questionnaire PSYCa 3-6.

Authors: Mouchenik Y Dauriac-Le Masson V Marquer C Marty-Chevreuil A Georges R Derivois D Moro MR
Journal Reference: L'Encephale 2017 Feb ; 43(1); 27-31. doi: 10.1016/j.encep.2016.04.002. Epub 2016 05 21
Children Earthquake Enfant Haiti Haïti PSYCa 3-6 Psychological screening Séisme Évaluation psychologique
Authors: Peyraud N Rafael F Parker LA Quere M Alcoba G Korff C Deats M Esteve PB Cabrol JC Serafini M Ciglenecki I Rull M Larabi IA Baud F Grandesso F Ilunga BK Alvarez JC Newton PN
Journal Reference: The Lancet. Global health 2017 02 ; 5(2); e137-e138. doi: 10.1016/S2214-109X(16)30287-X. Epub 2018 05 09

An alternative classification to mixture modeling for longitudinal counts or binary measures.


Classifying patients according to longitudinal measures, or trajectory classification, has become frequent in clinical research.

Authors: Subtil F Boussari O Bastard M Etard JF Ecochard R Génolini C
Journal Reference: Statistical methods in medical research 2017 Feb ; 26(1); 453-470. doi: 10.1177/0962280214549040. Epub 2016 09 30
binary data cluster analysis count data k-means likelihood longitudinal data