Detection and Quantification of Mycobacterium tuberculosis in the Sputum of Culture-Negative HIV-infected Pulmonary Tuberculosis Suspects: A Proof-of-Concept Study.


RATIONALE: Rapid diagnosis of pulmonary tuberculosis (TB) is critical for timely initiation of treatment and interruption of transmission. Yet, despite recent advances, many patients remain undiagnosed.

Authors: Madico G Mpeirwe M White L Vinhas S Orr B Orikiriza P Miller NS Gaeddert M Mwanga-Amumpaire J Palaci M Kreiswirth B Straight J Dietze R Boum Y Jones-López EC
Journal Reference: PloS one 2016 ; 11(7); e0158371. doi: 10.1371/journal.pone.0158371. Epub 2016 07 08

Closer to 90-90-90. The cascade of care after 10 years of ART scale-up in rural Malawi: a population study.


INTRODUCTION: The antiretroviral therapy (ART) programme supported by Médecins Sans Frontières in the rural Malawian district of Chiradzulu was one of the first in sub-Saharan Africa to scale up ART delivery in 2002.

Authors: Maman D Chilima B Masiku C Ayouba A Masson S Szumilin E Peeters M Ford N Heinzelmann A Riche B Etard JF
Journal Reference: Journal of the International AIDS Society 2016 ; 19(1); 20673. doi: 10.7448/IAS.19.1.20673. Epub 2016 02 15
HIV incidence prevalence viral load

Maternal perception of emotional difficulties of preschool children in rural Niger.


Mental health care for infants and young children is often greatly limited in low-resource settings. The purpose of this study was to describe maternal perception of emotional difficulties of preschool children in a rural area of Niger (Maradi).

Authors: Marquer C Grais RF Moro MR
Journal Reference: Transcultural psychiatry 2016 06 ; 53(3); 330-46. doi: 10.1177/1363461516645046. Epub 2018 02 15
community humanitarian identification perception psychological difficulties qualitative research young children

Cholera Rapid Test with Enrichment Step Has Diagnostic Performance Equivalent to Culture.


Cholera rapid diagnostic tests (RDT) could play a central role in outbreak detection and surveillance in low-resource settings, but their modest performance has hindered their broad adoption.

Authors: Ontweka LN Deng LO Rauzier J Debes AK Tadesse F Parker LA Wamala JF Bior BK Lasuba M But AB Grandesso F Jamet C Cohuet S Ciglenecki I Serafini M Sack DA Quilici ML Azman AS Luquero FJ Page AL
Journal Reference: PloS one 2016 ; 11(12); e0168257. doi: 10.1371/journal.pone.0168257. Epub 2016 12 19

Ebola Virus Disease Complications as Experienced by Survivors in Sierra Leone.


BACKGROUND: Thousands of people have survived Ebola virus disease (EVD) during the ongoing outbreak. However, data about the frequency and risk factors of long-term post-EVD complications remain scarce.

Authors: Tiffany A Vetter P Mattia J Dayer JA Bartsch M Kasztura M Sterk E Tijerino AM Kaiser L Ciglenecki I
Journal Reference: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016 06 01; 62(11); 1360-1366. doi: 10.1093/cid/ciw158. Epub 2016 03 21
Ebola complications survivors

Encouraging impact following 2.5 years of reinforced malaria control interventions in a hyperendemic region of the Republic of Guinea.


BACKGROUND: Malaria is one of the principal causes of morbidity and mortality in the Republic of Guinea, particularly in the highly endemic regions.

Authors: Tiffany A Moundekeno FP Traoré A Haile M Sterk E Guilavogui T Genton B Serafini M Grais RF
Journal Reference: Malaria journal 2016 05 28; 15(1); 298. doi: 10.1186/s12936-016-1353-z. Epub 2016 05 28
Cross sectional surveys Guinea Hyperendemic Malaria Plasmodium falciparum Prevalence Symptomatic

Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data.


BACKGROUND: Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors.

Journal Reference: BMC medicine 2016 May 24; 14(); 79. doi: 10.1186/s12916-016-0621-7. Epub 2016 05 24
Drug resistance Gametocyte Malaria Plasmodium falciparum

Potential impact of multiple interventions on HIV incidence in a hyperendemic region in Western Kenya: a modelling study.


BACKGROUND: Multiple prevention interventions, including early antiretroviral therapy initiation, may reduce HIV incidence in hyperendemic settings.

Authors: Blaizot S Maman D Riche B Mukui I Kirubi B Ecochard R Etard JF
Journal Reference: BMC infectious diseases 2016 Apr 29; 16(); 189. doi: 10.1186/s12879-016-1520-4. Epub 2016 04 29
Antiretroviral therapy HIV Hyperendemic settings Male circumcision Mathematical models Pre-exposure prophylaxis