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Four-Month High-Dose Rifampicin Regimens for Pulmonary Tuberculosis.

Jindani A Atwine D Grint D Bah B Adams J Ticona ER Shrestha B Agizew T Hamid S Jamil B Byamukama A Kananura K Mugisha Taremwa I Bonnet M Camara LM Bah-Sow OY Bah KS Bah NM Sow M Ticona Huaroto CE Mugruza Pineda R Tandukar B Raya BB Shrestha N Mathoma A Mathebula-Modongo UP Basotli J Irfan M Begum D Muzammil A Ahmed I Hasan R Burgos MV Sultan F Hassan M Masood I Robb C Decker J Grubnic S Butcher PD Witney A Dhillon J Munshi T Fielding K Harrison TS
NEJM evidence 2023 Sep ; 2(9); . doi: 10.1056/EVIDoa2300054. Epub 2023 08 22

Abstract

High-Dose Rifampicin Regimen for Pulmonary TuberculosisThis randomized, controlled trial tested the efficacy and safety of high-dose rifampicin (1200 or 1800 mg/d) as part of the treatment regimen for pulmonary tuberculosis. Four-month high-dose rifampicin regimens had no dose-limiting side effects but failed to meet noninferiority criteria compared with the standard 6-month control regimen.

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