Carriage prevalence and serotype distribution of Streptococcus pneumoniae prior to 10-valent pneumococcal vaccine introduction: A population-based cross-sectional study in South Western Uganda, 2014.

Nackers F Cohuet S le Polain de Waroux O Langendorf C Nyehangane D Ndazima D Nanjebe D Karani A Tumwesigye E Mwanga-Amumpaire J Scott JAG Grais RF
Vaccine 2017 09 18; 35(39); 5271-5277. doi: 10.1016/j.vaccine.2017.07.081. Epub 2017 08 04
Adult Children Nasopharyngeal carriage Pneumococcal conjugate vaccine Pneumococcal serotypes Streptococcus pneumoniae Uganda


BACKGROUND: Information on Streptococcus pneumoniae nasopharyngeal (NP) carriage before the pneumococcal conjugate vaccine (PCV) introduction is essential to monitor impact. The 10-valent PCV (PCV10) was officially introduced throughout Ugandan national childhood immunization programs in 2013 and rolled-out countrywide during 2014. We aimed to measure the age-specific Streptococcus pneumoniae carriage and serotype distribution across all population age groups in the pre-PCV10 era in South Western Uganda.

METHODS: We conducted a two-stage cluster, age-stratified, cross-sectional community-based study in Sheema North sub-district between January and March 2014. One NP swab was collected and analyzed for each participant in accordance with World Health Organization guidelines.

RESULTS: NP carriage of any pneumococcal serotype was higher among children

DISCUSSION: In Sheema district, the proportion of PCV10 serotypes was low (

Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.