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Unexpected detection of Mycobacterium tuberculosis DNA in US-born patients in putative association with clinical syndromes.

Abstract

Sequential inflammatory stages characterizing early tuberculosis (TB) disease and reports of differentially culturable M. tuberculosis have compounded existing gaps in the detection of paucibacillary TB disease, threatening global elimination goals.

Jones-López EC Miller NS Orr B White LF Vinhas S Mpeirwe M Orikiriza P Mwanga-Amumpaire J Palaci M Dietze R Boum Y Madico G
Nature communications 2026 Apr 14; 17(1); . doi: 10.1038/s41467-026-70890-6. Epub 2026 04 14

The Effect of Anemia on Mortality in Children Hospitalized with Severe Pneumonia in Uganda.

Abstract

OBJECTIVE: To examine the effect of anemia on mortality among children hospitalized with severe pneumonia in Uganda.

Moschovis PP Sharfi A Chaudhury S Sharma A Wiens MO Kumbakumba E Keneema O Nyehengane D Kabakyenga J Ansermino JM Kissoon N Christiani DC Dzik W Kiwanuka JP Hibberd PL
The Journal of pediatrics 2026 Mar 30; . doi: 10.1016/j.jpeds.2026.115090. Epub 2026 03 30

Pathways to care among women hospitalized with severe abortion complications in Bangui, Central African Republic, a conflict-affected urban setting: qualitative results of the AMoCo (abortion-related morbidity and mortality in conflict-affected and fragil

Abstract

BACKGROUND: The Central African Republic (CAR), a fragile and conflict-affected setting, has one of the highest maternal mortality ratios in the world.

Fetters T Lissouba P Schulte-Hillen C Lagrou D Moore AM Gbanzi MCA Ngbale R Powell B Fotheringham C Owolabi O Chen H Williams T Poulet E Pasquier E
Conflict and health 2026 Mar 21; . doi: 10.1186/s13031-026-00768-3. Epub 2026 03 21
Abortion Abortion pathways Central African Republic MSF Near-miss morbidity Postabortion care Postabortion complications

Comparative effectiveness of three linezolid management strategies for peripheral neuropathy during multidrug- or rifampicin-resistant tuberculosis treatment.

Abstract

BACKGROUND: Peripheral neuropathy frequently leads to linezolid dose reductions or interruptions during multidrug- or rifampicin-resistant tuberculosis treatment.

Romo M LaHood A Mitnick CD Rich ML Trevisi L Skrahina A Oyewusi L Bastard M Khan PY Huerga H Khan U Flores EH Atshemyan H Hewison C Rashitov M Samieva N Gómez-Restrepo C Krisnanda A Kotrikadze T Siraj F Khan AW Ndjeka N Adenov M Seung K Kumsa A Franke MF
medRxiv : the preprint server for health sciences 2026 Mar 16; . doi: 10.64898/2026.03.14.26348377. Epub 2026 03 16
Drug-Related Side Effects and Adverse Reactions Linezolid Multidrug-Resistant Peripheral Nervous System Diseases Treatment Outcome Tuberculosis

Relevance of more stringent discharge standards for acute malnutrition treatment: A pooled analysis of post-treatment relapse in 21 studies.

Abstract

BACKGROUND: The World Health Organization recently recommended that both Weight-for-Height Z-score (WHZ) and Mid-Upper-Arm-Circumference (MUAC) exceed Moderate Acute Malnutrition (MAM) thresholds before a child with Severe Acute Malnut

Guesdon B Rattigan SM Grellety E Bliznashka L Donnen P Bilukha O
The American journal of clinical nutrition 2026 Mar 11; . doi: 10.1016/j.ajcnut.2026.101264. Epub 2026 03 11
Anthropometry acute malnutrition case definition discharge relapse wasting

Oral rehydration for severe malnutrition in children with moderate and severe dehydration (GASTROSAM): a phase 2, open-label, superiority randomised controlled trial.

Abstract

BACKGROUND: International guidelines for treatment of children with severe acute malnutrition advise against giving standard oral rehydration solutions (ORS) for dehydration secondary to diarrhoea.

Maitland K Sainna H Connon R Ouattara SM Sunyoto T Chara A Ogundipe OF Maguina AS Hamaluba M Olupot-Olupot P Alaroker F Okiror W Aromut D Mwajombo E Oguda E Mogaka C Langendorf C Dewez JE Ciglenecki I Gibb DM Petrucci R Coldiron ME George EC
The Lancet. Child & adolescent health 2026 Mar 10; . doi: 10.1016/S2352-4642(25)00371-2. Epub 2026 03 10

Effect of COVID-19 pandemic on ART access and timely initiation in people living with HIV in 31 countries: a regression discontinuity design study.

Abstract

OBJECTIVES: The COVID-19 pandemic threatened global HIV Test and Treat Efforts.

Ben Farhat J Messou E Borse R Varela Bustillo D Madimabe M Nash D Byakwaga H Shah NS Ezechi O Pujari S Veloso VG Hobbins M Murenzi G Mkwashapi D Hogan B Choi JY Minga A Crabtree-Ramírez B Twizere C Diero L Haw J Bolton-Moore C Cortes CP Lee MP Mbewe S Brazier E Humphrey JM Althoff KN Bonnet F Barger D Jaquet A
BMJ open 2026 Mar 10; 16(3); . doi: 10.1136/bmjopen-2025-112903. Epub 2026 03 10
COVID-19 Drug Therapy HIV & AIDS

Strengthening research regulatory capacity in the East African community: a multi-country training program on emerging and complex study designs.

Abstract

BACKGROUND: The East African Community (EAC) has experienced a significant increase in volume and complexity of clinical research driven by the epidemics of emerging and re-emerging infectious diseases such as HIV, Ebola, COVID-19, and

Amperiize M Twesigye B Mutumba B Opolot H Gardais S Wandiga S Ndagije H Kidola J Mutabazi V Nyandwi R Mathew LS Twungubumwe N Castelnuovo B Arinaitwe JW Okoboi S Ainembabazi P Byakika-Kibwika P
BMC medical ethics 2026 Mar 02; . doi: 10.1186/s12910-026-01418-2. Epub 2026 03 02
Capacity building Emerging and complex study designs National research regulatory authority Research ethics committees Researchers

Multicountry genomic analysis underscores regional cholera spread in Africa.

Abstract

Cholera remains a significant public health burden in many countries in sub-Saharan Africa, though the exact mechanisms of bacterial emergence and spread remain largely undefined.

Mboowa G Matteson NL Tanui CK Kasonde M Kamwiziku GK Akanbi OA Chitio JJE Kagoli M Essomba RG Ayitewala A Ssewanyana I Ngo Bitoungui VJ Amuri AA Azman AS Babatunde OA Akenji BM Broban A Malembaka EB Ongole F Chukwu CE Ismael N Kapona O Laurindo O Mbala PK Etoundi Mballa GA Miambo ICZ Mwanyongo AA Najjuka G Mutale J Musonda K Niyonzima AM Nyenje ME Popoola M Shempela DM Sike CM Sitoe SM Wanjohi DW Welo PO Yelewa M Yennan S Ziba L Bitilinyu-Bangoh JE Chilengi R Hadja H Idris J Langa JPM Mukadi-Bamuleka D Nabadda S Debes AK Sack DA Tebeje YK Wohl S Tessema SK
Nature communications 2026 Feb 09; . doi: 10.1038/s41467-026-68642-7. Epub 2026 02 09

Estimating the effect of hepatitis C infection on multidrug-resistant tuberculosis treatment outcomes under hypothetical interventions on regimen composition and adherence.

Abstract

Hepatitis C virus (HCV) infection is associated with unfavorable multidrug- and rifampicin-resistant (MDR/RR) tuberculosis (TB) outcomes.

LaHood A Robins J Stagg HR Sauer S Ahmed S Bastard M Guglielmetti L Hewison C Huerga H Isani AK Khan P Khan U Lomtadze N Mamsa S Melikyan N Mitnick CD Rich ML Seung K Siddiqui MR Skrahina A Stambekova A Tefera GB Franke MF
American journal of epidemiology 2026 Feb 02; . doi: 10.1093/aje/kwag024. Epub 2026 02 02
Multidrug-resistant tuberculosis hepatitis C losses-to-follow-up rifampicin-resistant tuberculosis treatment adherence