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Burden of malaria among children aged 5-10 years in the Sahelian area: do we need to adapt seasonal malaria chemoprophylaxis?

Abstract

BACKGROUND: Despite its Sahelian context, Niger is one of the sub-Saharan countries reporting the highest number of malaria cases.

Djedanem M Yacoubou MAY Zakari A Issa I Yahaya M Zaneidou M Mody I Onana DB Testa J Jambou R
BMC infectious diseases 2026 Jan 30; . doi: 10.1186/s12879-025-12286-3. Epub 2026 01 30
Chemoprevention Children Malaria Niger Sahel Seasonal transmission

Low-dose yellow fever vaccination in infants: a randomised, double-blind, non-inferiority trial.

Abstract

BACKGROUND: WHO recommends fractional dose vaccination to address yellow fever vaccine shortages during outbreaks.

Kimathi D Juan-Giner A Bob NS Orindi B Namulwana ML Diatta A Cheruiyot S Fall G Dia M Hamaluba MM Nyehangane D Karanja HK Gitonga JN Mugo D Omuoyo DO Hussein M Oloo E Kamau N Wafula J Bendera J Silvester N Mwavita J Joshua M Thuranira JM Agababyona C Ngetsa C Aisha N Moki F Buluku T Munene M Mwanga-Amumpaire J Lutwama J Kayiwa J Kamaara E Barrett AD Kaleebu P Bejon P Sall AA Grais RF Warimwe GM
Lancet (London, England) 2026 Jan 13; . doi: 10.1016/S0140-6736(25)02069-0. Epub 2026 01 13

Community and hospital-acquired invasive bacterial infections in hospitalised patients with advanced HIV disease: a prospective study in Kinshasa, DRC.

Abstract

BACKGROUND: Advanced HIV patients face high mortality, often from invasive bacterial infections (IBI), while rising antimicrobial resistance (AMR) threatens treatment.

Langendorf C Bossard C Nackers F Comelli A Berghmans M Molay G Gomez FG Dicko A Bangwen E Kalwangila T Mangana F Kilundu A Beni RN Mboyo A Burton R Lumowo GM Isaakidis P
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2026 Jan 10; . doi: 10.1016/j.ijid.2026.108383. Epub 2026 01 10
Invasive bacterial infection advanced HIV disease antimicrobial resistance low-resource settings

Health-economic impacts of age-targeted and sex-targeted Lassa fever vaccination in endemic regions of Nigeria, Guinea, Liberia, and Sierra Leone: a modelling study.

Abstract

BACKGROUND: Lassa fever is an emerging zoonotic disease endemic to west Africa.

Smith DRM Antony Oliver MC Holohan KM Street HR Torkelson AA Asogun D Ayodeji OO Azuogu BN Camacho A Fischer WA Grant DS Jan K Okogbenin SA Sibley J Wohl DA Hollingsworth TD Pouwels KB
The Lancet. Global health 2026 Feb ; 14(2); . doi: 10.1016/S2214-109X(25)00450-4. Epub 2026 01 10

Trends in Plasmodium falciparum resistance markers to sulfadoxine-pyrimethamine and amodiaquine over ten years of seasonal malaria chemoprevention in Moissala Health District, Chad.

Abstract

BACKGROUND: Seasonal Malaria Chemoprevention (SMC) has been implemented in Moissala Health District, southern Chad, since 2013 using the standard regimen of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ).

Grandesso F Diar MSI Kouassi F Hilario JS Ouedraogo P Djimde AA Singh S Dama S
Malaria journal 2025 Dec 31; . doi: 10.1186/s12936-025-05771-2. Epub 2025 12 31
Plasmodium falciparum Amodiaquine Chad Malaria Molecular markers of resistance Seasonal malaria chemoprevention Sulfadoxine-pyrimethamine

Burden of malaria in young adults in Niger: A prospective study in a military setting.

Abstract

In Niger, malaria remains a major public health issue and cause of economic loss, but its impact on young adults remains poorly documented. Although this population is central to the country's development, it is rarely studied.

Aminou YY Hamidou B Djedanem M Ramatoulaye HL Moustapha WA Testa J Jambou R
Acta tropica 2025 Dec 27; 273; . doi: 10.1016/j.actatropica.2025.107958. Epub 2025 12 27
Burden Cost FDS Geo-climatic conditions Malaria Niger Prevalence

Effect of smoking on drug-resistant tuberculosis treatment outcomes and potential mechanistic pathways: a multicountry cohort study.

Abstract

BACKGROUND: People who smoke are at increased risk of unfavourable tuberculosis treatment outcomes compared with those who do not, but the pathways that explain this disparity are unclear.

Romo ML LaHood A Stagg HR Mitnick CD Trevisi L Hewison C Padayachee S Herrera Flores E Oyewusi L Khan PY Huerga H Bastard M Rich ML Tefera GB Rashitov M Kirakosyan O Krisnanda A Toktogonova A Siddiqui MR Gómez-Restrepo C Kotrikadze T Franke MF
BMJ open respiratory research 2025 Dec 25; 12(1); . doi: 10.1136/bmjresp-2025-003777. Epub 2025 12 25
Clinical Epidemiology Compliance Tobacco and the lung Tuberculosis

Not forgetting the humanitarian contexts in the fight against antimicrobial resistance: Operational-driven reflection on knowledge and research gaps by Médecins Sans Frontières.

Abstract

Despite Antimicrobial Resistance (AMR) being a growing threat to global public health, there is scarce evidence from humanitarian settings.

Garcia-Vello P Naim C Langendorf C Shortall C Jasovský D Gomez FG Hanna DA Khalife M Broomand A Wagan J Poupard M Adjaho I Baidjoe A Kanapathipillai R Farra A
PLOS global public health 2025 ; 5(12); . doi: 10.1371/journal.pgph.0005498. Epub 2025 12 11

Barriers to accessing and using primary and secondary healthcare among children under-five in the Koutiala health district of Mali.

Abstract

BACKGROUND: A 2022 survey conducted in Koutiala suggested a modest increase in the mortality rate and low utilization of healthcare facilities among children under-five i.e., children less than five years old.

Yakum MN Gignoux E Kalossi I Sidibe YD Gamba FC Koudika MH Grellety E
BMC public health 2025 Dec 10; . doi: 10.1186/s12889-025-25887-z. Epub 2025 12 10
Access Barriers Children Health-seeking-behaviors Healthcare Referrals Utilization under-five

Setting research priorities for sexual and reproductive health in humanitarian settings: a global, stakeholder-informed agenda.

Abstract

BACKGROUND: Sexual and reproductive health and rights (SRHR) remain critically underfunded and underresearched in humanitarian settings.

Nam SL Abril A McKay G Casey SE Bossard C Moore AM Seyoum T Christou A Paracchini S Lledó Weber P Fetters T Singh N Grau E Sleiman T Blanchet K
Conflict and health 2025 Dec 07; . doi: 10.1186/s13031-025-00734-5. Epub 2025 12 07
Humanitarian settings Reproductive health Research priorities Sexual health