This paper shows the scale of global health research and the context in which we frame the subsequent papers in the Series.
Evaluating whether an intervention works when trialled in groups of individuals can pose complex challenges for clinical research.
In global health research, short-term, small-scale clinical trials with fixed, two-arm trial designs that generally do not allow for major changes throughout the trial are the most common study design.
BACKGROUND: In low-and-middle-income countries (LMIC), data related to antimicrobial resistance (AMR) are often inconsistently collected.
BACKGROUND: Unrest in Myanmar in August 2017 resulted in the movement of over 700,000 Rohingya refugees to overcrowded camps in Cox's Bazar, Bangladesh. A large outbreak of diphtheria subsequently began in this population.
BACKGROUND: Patients hospitalized with advanced HIV have a high mortality risk.
BACKGROUND: In high tuberculosis (TB) burden settings, there is growing evidence that TB is common in children with pneumonia, the leading cause of death in children under 5 years worldwide.
BACKGROUND: There are major gaps in the management of pediatric tuberculosis (TB) contact investigation for rapid identification of active tuberculosis and initiation of preventive therapy.
