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Development of a dosing-adjustment tool for fluoroquinolones in osteoarticular infections: The Fluo-pop study.

Abstract

Fluoroquinolones efficacy depend on both the drug exposure and the level of drug resistance of the bacteria responsible for the infection.

Lemaitre F Fily F Foulquier JB Revest M Jullien V Petitcollin A Tattevin P Tron C Polard JL Verdier MC Comets E Huten D Arvieux C Bellissant E Laviolle B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug 19; 142 112053. doi: 10.1016/j.biopha.2021.112053. Epub 2021 08 19
Bone infection Joint infection Modeling Ofloxacin Pharmacokinetics

A feasibility study using mid-upper arm circumference as the sole anthropometric criterion for admission and discharge in the outpatient treatment for severe acute malnutrition.

Abstract

BACKGROUND: The World Health Organization recommends the use of a weight-for-height Z-score (WHZ) and/or mid-upper arm circumference (MUAC) as anthropometric criteria for the admission and discharge of young children for the community-

Garba S Salou H Nackers F Ayouba A Escruela M Guindo O Rocaspana M Grais RF Isanaka S
BMC nutrition 2021 Aug 12; 7(1); 47. doi: 10.1186/s40795-021-00448-w. Epub 2021 08 12
Admission criteria Community-based management of acute malnutrition Discharge criteria Mid-upper arm circumference Niger Severe acute malnutrition Wasting

The HIV cascade of care among serodiscordant couples in four high HIV prevalence settings in sub-Saharan Africa.

Abstract

BACKGROUND:  HIV-serodiscordant couples are at high risk of HIV transmission. In sub-Saharan Africa, HIV-serodiscordant couples contribute ~30% of all new infections in the region.

Chihana ML Conan N Ellman T Poulet E Garone DB Ortuno R Wanjala S Masiku C Etard JF Davies MA Maman D
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2021 Aug 02; 111(8); . doi: 10.7196/SAMJ.2021.v111i8.15489. Epub 2021 08 02

How to improve outbreak response: a case study of integrated outbreak analytics from Ebola in Eastern Democratic Republic of the Congo.

Abstract

The emerging field of outbreak analytics calls attention to the need for data from multiple sources to inform evidence-based decision making in managing infectious diseases outbreaks.

Carter SE Ahuka-Mundeke S Pfaffmann Zambruni J Navarro Colorado C van Kleef E Lissouba P Meakin S le Polain de Waroux O Jombart T Mossoko M Bulemfu Nkakirande D Esmail M Earle-Richardson G Degail MA Umutoni C Anoko JN Gobat N
BMJ global health 2021 Aug ; 6(8); . doi: 10.1136/bmjgh-2021-006736. Epub 2021 08 20
epidemiology health services research other study design public health viral haemorrhagic fevers

Performance of six rapid diagnostic tests for SARS-CoV-2 antigen detection and implications for practical use.

Abstract

BACKGROUND: Direct detection of SARS-CoV-2 viral proteins in nasopharyngeal swabs using lateral flow immunoassays is a simple, fast and cheap approach to diagnose the infection.

Fourati S Langendorf C Audureau E Challine D Michel J Soulier A Ahnou N Désveaux I Picard O Ortonne V Gourgeon A Mills C Hémery F Rieux C Pawlotsky JM Malou N Chevaliez S
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2021 Jul 25; 142 104930. doi: 10.1016/j.jcv.2021.104930. Epub 2021 07 25
Antigen assay COVID-19 Diagnostic Rapid diagnostic test SARS-CoV-2 Screening

Serologic response to SARS-CoV-2 in an African population.

Abstract

Official case counts suggest Africa has not seen the expected burden of COVID-19 as predicted by international health agencies, and the proportion of asymptomatic patients, disease severity, and mortality burden differ significantly in Africa from what

Fai KN Corine TM Bebell LM Mboringong AB Nguimbis EBPT Nsaibirni R Mbarga NF Eteki L Nikolay B Essomba RG Ndifon M Ntone R Hamadou A Matchim L Tchiasso D Abah Abah AS Essaka R Peppa S Crescence F Ouamba JP Koku MT Mandeng N Fanne M Eyangoh S Mballa GAE Esso L Epée E Njouom R Okomo Assoumou MC Boum Y
Scientific African 2021 Jul ; 12 e00802. doi: 10.1016/j.sciaf.2021.e00802. Epub 2021 05 30
Africa COVID-19 Immunoglobulin Rapid diagnostic tests Serology

Rotavirus vaccine efficacy up to 2 years of age and against diverse circulating rotavirus strains in Niger: Extended follow-up of a randomized controlled trial.

Abstract

BACKGROUND: Rotavirus vaccination is recommended in all countries to reduce the burden of diarrhea-related morbidity and mortality in children.

Isanaka S Langendorf C McNeal MM Meyer N Plikaytis B Garba S Sayinzoga-Makombe N Soumana I Guindo O Makarimi R Scherrer MF Adehossi E Ciglenecki I Grais RF
PLoS medicine 2021 Jul ; 18(7); e1003655. doi: 10.1371/journal.pmed.1003655. Epub 2021 07 02