Publications

Mortality and Cause of Death in Children With Presumptive Disseminated Tuberculosis.

Abstract

BACKGROUND AND OBJECTIVES: Children experience high tuberculosis (TB)-related mortality but causes of death among those with presumptive TB are poorly documented.

Bonnet M Nordholm AC Ssekyanzi B Byamukama O Orikiriza P Tusabe T Nyehangane D Taremwa IM Turyashemererwa E Wobudeya E Mwanga-Amumpaire J Marais BJ Nampijja D
Pediatrics 2023 Apr 01; 151(4); . doi: 10.1542/peds.2022-057912. Epub 2023 04 04

A prospective, multi-site, cohort study to estimate incidence of infection and disease due to Lassa fever virus in West African countries (the Enable Lassa research programme)-Study protocol.

Abstract

BACKGROUND: Lassa fever (LF), a haemorrhagic illness caused by the Lassa fever virus (LASV), is endemic in West Africa and causes 5000 fatalities every year.

Penfold S Adegnika AA Asogun D Ayodeji O Azuogu BN Fischer WA Garry RF Grant DS Happi C N'Faly M Olayinka A Samuels R Sibley J Wohl DA Accrombessi M Adetifa I Annibaldis G Camacho A Dan-Nwafor C Deha ARE DeMarco J Duraffour S Goba A Grais R Günther S Honvou ÉJJP Ihekweazu C Jacobsen C Kanneh L Momoh M Ndiaye A Nsaibirni R Okogbenin S Ochu C Ogbaini E Logbo ÉPMA Sandi JD Schieffelin JS Verstraeten T Vielle NJ Yadouleton A Yovo EK
PloS one 2023 ; 18(3); . doi: 10.1371/journal.pone.0283643. Epub 2023 03 30

It takes more than a machine: A pilot feasibility study of point-of-care HIV-1 viral load testing at a lower-level health center in rural western Uganda.

Abstract

Barriers continue to limit access to viral load (VL) monitoring across sub-Saharan Africa adversely impacting control of the HIV epidemic.

Boyce RM Ndizeye R Ngelese H Baguma E Shem B Rubinstein RJ Rockwell E Lotspeich SC Shook-Sa BE Ntaro M Nyehangane D Wohl DA Siedner MJ Mulogo EM
PLOS global public health 2023 ; 3(3); . doi: 10.1371/journal.pgph.0001678. Epub 2023 03 27

Assessment of the proportion of households with burn victims, associated risk factors and knowledge of burn injury prevention strategies in South Western Uganda. A population based cross sectional survey.

Abstract

BACKGROUND: Burn injuries are a major cause of morbidity and mortality within Low- and Middle-income countries (LMICs). Most of these burn injuries occur at home with children most at risk.

Martin T Nanjebe D Atwine D
Burns : journal of the International Society for Burn Injuries 2023 Mar 24; . doi: 10.1016/j.burns.2023.03.016. Epub 2023 03 24
Adults Burn prevention Children Electricity protective Household burns Uganda

Acceptability of a new 4-in-1 Abacavir/Lamivudine/Lopinavir/Ritonavir paediatric fixed-dose combination: the caregiver-child dyads' perspective.

Abstract

BACKGROUND: Worldwide, 1.7 million children younger than 15 years were living with HIV in 2021. Only 52% of them had access to antiretrovirals (ARVs). Lack of age-appropriate ARV formulations (i.e.

Rotsaert A Ogara C Mwanga-Amumpaire J Kekitiinwa AR Musiime V Najjingo E Kisitu GP Nazzinda R Nambi E Lee J Diallo M Kyomuhendo F Waweru M Andrieux-Meyer I Nöstlinger C
Therapeutic advances in infectious disease 2023 ; 10; . doi: 10.1177/20499361231159993. Epub 2023 03 21
HIV acceptability antiretroviral therapy fixed-dose combination paediatric ARV

Protection, health seeking, or a laissez-passer: Participants' decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo.

Abstract

During the 10th Ebola virus disease (EVD) epidemic in the eastern Democratic Republic of the Congo (DRC) (2018-2020), two experimental EVD vaccines were deployed in North Kivu.

James M Kasereka JG Kasiwa B Kavunga-Membo H Kambale K Grais R Muyembe-Tamfum JJ Bausch DG Watson-Jones D Lees S
Social science & medicine (1982) 2023 Mar 15; 323; . doi: 10.1016/j.socscimed.2023.115833. Epub 2023 03 15
Clinical trials DRC Ebola Epidemics Vaccine

Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis.

Abstract

BACKGROUND: Many children with pulmonary tuberculosis remain undiagnosed and untreated with related high morbidity and mortality.

Gunasekera KS Marcy O Muñoz J Lopez-Varela E Sekadde MP Franke MF Bonnet M Ahmed S Amanullah F Anwar A Augusto O Aurilio RB Banu S Batool I Brands A Cain KP Carratalá-Castro L Caws M Click ES Cranmer LM García-Basteiro AL Hesseling AC Huynh J Kabir S Lecca L Mandalakas A Mavhunga F Myint AA Myo K Nampijja D Nicol MP Orikiriza P Palmer M Sant'Anna CC Siddiqui SA Smith JP Song R Thuong Thuong NT Ung V van der Zalm MM Verkuijl S Viney K Walters EG Warren JL Zar HJ Marais BJ Graham SM Debray TPA Cohen T Seddon JA
The Lancet. Child & adolescent health 2023 Mar 13; . doi: 10.1016/S2352-4642(23)00004-4. Epub 2023 03 13

Evaluation of a Paediatric Early Warning System (PEWS) score on admission to a paediatric intensive care unit to predict mortality risk in a low resource setting, Guinea-Bissau

Abstract

CONTEXT: The Paediatric Early Warning System (PEWS) is a clinical monitoring tool used routinely in emergency and observation rooms to detect rapid deterioration in paediatric patients, allowing timely action.

Temessadouno F W Hiffler L Gallo J Gignoux E Domenichini C Janet S et al.
J Community Med Public Health Care 2023, 10: 125. doi: 10.24966/CMPH-1978/100012
Low resources setting PEWS PICU

High performance of systematic combined urine LAM test and sputum Xpert MTB/RIF® for tuberculosis screening in severely immunosuppressed ambulatory adults with HIV.

Abstract

BACKGROUND: In people with HIV (PWH), the WHO-recommended tuberculosis four-symptom screen (W4SS) targeting those who need molecular rapid test may be suboptimal.

Bonnet M Gabillard D Domoua S Muzoora C Messou E Sovannarith S Nguyen DB Badje A Juchet S Bunnet D Borand L Natukunda N Tran TH Anglaret X Laureillard D Blanc FX
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2023 Mar 08; . doi: 10.1093/cid/ciad125. Epub 2023 03 08
HIV diagnosis screening tuberculosis