Genomic history of the seventh pandemic of cholera in Africa.

Authors: Weill FX Domman D Njamkepo E Tarr C Rauzier J Fawal N Keddy KH Salje H Moore S Mukhopadhyay AK Bercion R Luquero FJ Ngandjio A Dosso M Monakhova E Garin B Bouchier C Pazzani C Mutreja A Grunow R Sidikou F Bonte L Breurec S Damian M Njanpop-Lafourcade BM Sapriel G Page AL Hamze M Henkens M Chowdhury G Mengel M Koeck JL Fournier JM Dougan G Grimont PAD Parkhill J Holt KE Piarroux R Ramamurthy T Quilici ML Thomson NR
Journal Reference: Science (New York, N.Y.) 2017 11 10; 358(6364); 785-789. doi: 10.1126/science.aad5901. Epub 2018 04 10
eng

Abstract

The seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa.

Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.