Mortality and clinical outcomes in children treated with antiretroviral therapy in four African vertical programmes during the first decade of paediatric HIV care, 2001-2010.

Authors: Ben-Farhat J Schramm B Nicolay N Wanjala S Szumilin E Balkan S Pujades-Rodríguez M
Journal Reference: Tropical medicine & international health : TM & IH 2017 03 ; 22(3); 340-350. doi: 10.1111/tmi.12830. Epub 2017 01 26

HIV
antiretroviral therapy cohort studies mortality paediatrics treatment failure
eng

Abstract

OBJECTIVE: To assess mortality and clinical outcomes in children treated with antiretroviral therapy (ART) in four African vertical programmes between 2001 and 2010.

METHODS: Cohort analysis of data from HIV-infected children (

RESULTS: A total of 3949 children, 22.7% aged

CONCLUSIONS: Good treatment outcomes were achieved during the first decade of HIV paediatric care despite the late start of therapy. Encouraging early HIV infant diagnosis in and outside prevention of mother-to-child transmission programmes, and linkage to care services for early ART initiation, is needed to reduce mortality and delay treatment failure.

© 2016 John Wiley & Sons Ltd.