Publications

The endTB observational study protocol: treatment of MDR-TB with bedaquiline or delamanid containing regimens.

Abstract

BACKGROUND: At a time when programs were struggling to design effective regimens for the treatment of multidrug-resistant tuberculosis (MDR-TB), the marketing authorization of bedaquiline and delamanid was a critical development in the

Khan U Huerga H Khan AJ Mitnick CD Hewison C Varaine F Bastard M Rich M Franke MF Atwood S Khan PY Seung KJ
BMC infectious diseases 2019 Aug 20; 19(1); 733. doi: 10.1186/s12879-019-4378-4. Epub 2019 08 20
Bedaquiline Delamanid Efficacy MDR-TB Safety

Point-of-care viral load monitoring: outcomes from a decentralized HIV programme in Malawi.

Abstract

INTRODUCTION: Routinely monitoring the HIV viral load (VL) of people living with HIV (PLHIV) on anti-retroviral therapy (ART) facilitates intensive adherence counselling and faster ART regimen switch when treatment failure is indicated

Nicholas S Poulet E Wolters L Wapling J Rakesh A Amoros I Szumilin E Gueguen M Schramm B
Journal of the International AIDS Society 2019 Aug ; 22(8); e25387. doi: 10.1002/jia2.25387. Epub 2019 08 23

HIV
90-90-90 Decentralization HIV Care Continuum Health System Strengthening Treatment failure Treatment monitoring

Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis.

Abstract

BACKGROUND: Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potentially preclude/pre-empt the detection of subsequent r

Malaria journal 2019 Jul 05; 18(1); 225. doi: 10.1186/s12936-019-2837-4. Epub 2019 07 05
Competing risk event Plasmodium falciparum Treatment efficacy study

Effectiveness of oral cholera vaccine in preventing cholera among fishermen in Lake Chilwa, Malawi: A case-control study.

Abstract

BACKGROUND: In response to a cholera outbreak among mobile, difficult-to-reach fishermen on Lake Chilwa, Malawi in 2016, a novel vaccine distribution strategy exploited the proven vaccine thermostability.

Grandesso F Kasambara W Page AL Debes AK M'bang'ombe M Palomares A Lechevalier P Pezzoli L Alley I Salumu L Msyamboza K Sack D Cohuet S Luquero FJ
Vaccine 2019 Jun 19; 37(28); 3668-3676. doi: 10.1016/j.vaccine.2019.05.044. Epub 2019 05 24
Cholera Effectiveness Hard-to-reach populations Malawi Thermostability Vaccine

Severe acute malnutrition results in lower lumefantrine exposure in children treated with artemether-lumefantrine for uncomplicated malaria.

Abstract

Severe acute malnutrition (SAM) has been reported to be associated with increased malaria morbidity in Sub-Saharan African children and may affect the pharmacology of antimalarial drugs.

Chotsiri P Denoeud-Ndam L Baudin E Guindo O Diawara H Attaher O Smit M Guerin PJ Doumbo OK Wiesner L Barnes KI Hoglund RM Dicko A Etard JF Tarning J
Clinical pharmacology and therapeutics 2019 Jun 01; . doi: 10.1002/cpt.1531. Epub 2019 06 01
Lumefantrine malaria malnutrition non-linear mixed effects modelling population pharmacokinetic-pharmacodynamic model severe acute malnutrition children

Utility of Clinical and Laboratory Decision Rules in Identifying Bacterial Meningitis Among Children with Suspicion of Central Nervous System Infections in a Malaria-Endemic Area, Mbarara, Uganda.

Abstract

Several decision rules combining clinical and biological parameters have been proposed to distinguish bacterial from aseptic meningitis, but have not been evaluated in Africa.

Boum Y Nyehangane D Llosa AE Saliez N Nanjebe D Kemigisha E Charrel RN Baron E Mwanga-Amumpaire J Page AL
The Pediatric infectious disease journal 2019 Jun ; 38(6); e131-e133. doi: 10.1097/INF.0000000000002185. Epub 2019 05 22

Cost-effectiveness of community-based screening and treatment of moderate acute malnutrition in Mali.

Abstract

Introduction: Moderate acute malnutrition (MAM) causes substantial child morbidity and mortality, accounting for 4.4% of deaths and 6.0% of disability-adjusted life years (DALY) lost among children under 5 each year.

Isanaka S Barnhart DA McDonald CM Ackatia-Armah RS Kupka R Doumbia S Brown KH Menzies NA
BMJ global health 2019 ; 4(2); e001227. doi: 10.1136/bmjgh-2018-001227. Epub 2019 04 28
CSB++ Mali PlumpySup Super Cereal corn soy blend cost cost-effectiveness moderate acute malnutrition ready to use supplementary foods

Delayed second dose of oral cholera vaccine administered before high-risk period for cholera transmission: Cholera control strategy in Lusaka, 2016.

Abstract

BACKGROUND: In April 2016, an emergency vaccination campaign using one dose of Oral Cholera Vaccine (OCV) was organized in response to a cholera outbreak that started in Lusaka in February 2016.

Ferreras E Matapo B Chizema-Kawesha E Chewe O Mzyece H Blake A Moonde L Zulu G Poncin M Sinyange N Kasese-Chanda N Phiri C Malama K Mukonka V Cohuet S Uzzeni F Ciglenecki I Danovaro-Holliday MC Luquero FJ Pezzoli L
PloS one 2019 ; 14(8); e0219040. doi: 10.1371/journal.pone.0219040. Epub 2019 08 30