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Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): A Phase II Randomised Controlled trial: Trial Protocol.

Abstract

BACKGROUND: Children hospitalised with severe acute malnutrition (SAM) are frequently complicated (>50%) by diarrhoea ( ≥3 watery stools/day) which is accompanied by poor outcomes.

Olupot-Olupot P Aloroker F Mpoya A Mnjalla H Paasi G Nakuya M Houston K Obonyo N Hamaluba M Evans JA Dewez M Atti S Guindo O Ouattara SM Chara A Sainna HA Amos OO Ogundipe O Sunyoto T Coldiron M Langendorf C Scherrer MF Petrucci R Connon R George EC Gibb DM Maitland K
Wellcome open research 2021 ; 6; . doi: 10.12688/wellcomeopenres.16885.2. Epub 2024 01 16
African Children Dehydration Gastroenteritis Intravenous fluids Rehydration Severe Malnutrition WHO guidelines

Adolescents and young adults are the most undiagnosed of HIV and virally unsuppressed in Eastern and Southern Africa: Pooled analyses from five population-based surveys.

Abstract

Age and gender disparities within the HIV cascade of care are critical to focus interventions efficiently. We assessed gender-age groups at the highest probability of unfavorable outcomes in the HIV cascade in five HIV prevalent settings.

Huerga H Ben Farhat J Maman D Conan N Van Cutsem G Omwoyo W Garone D Ortuno Gutierrez R Apollo T Okomo G Etard JF
PLOS global public health 2023 ; 3(12); . doi: 10.1371/journal.pgph.0002398. Epub 2023 12 22

Genomic surveillance of SARS-CoV-2 reveals highest severity and mortality of delta over other variants: evidence from Cameroon.

Abstract

While the SARS-CoV-2 dynamic has been described globally, there is a lack of data from Sub-Saharan Africa. We herein report the dynamics of SARS-CoV-2 lineages from March 2020 to March 2022 in Cameroon.

Fokam J Essomba RG Njouom R Okomo MA Eyangoh S Godwe C Tegomoh B Otshudiema JO Nwobegahay J Ndip L Akenji B Takou D Moctar MMM Mbah CK Ndze VN Maidadi-Foudi M Kouanfack C Tonmeu S Ngono D Nkengasong J Ndembi N Bissek AZK Mouangue C Ndongo CB Epée E Mandeng N Kamso Belinga S Ayouba A Fernandez N Tongo M Colizzi V Halle-Ekane GE Perno CF Ndjolo A Ndongmo CB Shang J Esso L de-Tulio O Diagne MM Boum Y Mballa GAE Njock LR
Scientific reports 2023 Dec 08; 13(1); . doi: 10.1038/s41598-023-48773-3. Epub 2023 12 08

Experiences and perceptions of urine sampling for tuberculosis testing among HIV patients: a multisite qualitative descriptive study.

Abstract

OBJECTIVES: Evidence on the acceptability of urine-based assays for tuberculosis (TB) diagnosis among patients remains limited.

Lissouba P Rücker SCM Otieno LA Akatukwasa C Xulu S Monjane C Akinyi M Okal B Lubega AV Stewart R Bossard C Ohler L Antabak NT Musoke M Muyindike W Huerga H
BMJ open 2023 Nov 30; 13(11); . doi: 10.1136/bmjopen-2021-058805. Epub 2023 11 30
Public health QUALITATIVE RESEARCH Tuberculosis

Evaluating newly approved drugs in combination regimens for multidrug-resistant tuberculosis with fluoroquinolone resistance (endTB-Q): study protocol for a multi-country randomized controlled trial.

Abstract

BACKGROUND: Treatment for fluoroquinolone-resistant multidrug-resistant/rifampicin-resistant tuberculosis (pre-XDR TB) often lasts longer than treatment for less resistant strains, yields worse efficacy results, and causes substantial

Patil SB Tamirat M Khazhidinov K Ardizzoni E Atger M Austin A Baudin E Bekhit M Bektasov S Berikova E Bonnet M Caboclo R Chaudhry M Chavan V Cloez S Coit J Coutisson S Dakenova Z De Jong BC Delifer C Demaisons S Do JM Dos Santos Tozzi D Ducher V Ferlazzo G Gouillou M Khan U Kunda M Lachenal N LaHood AN Lecca L Mazmanian M McIlleron H Moreau M Moschioni M Nahid P Osso E Oyewusi L Panda S Pâquet A Thuong Huu P Pichon L Rich ML Rupasinghe P Salahuddin N Sanchez Garavito E Seung KJ Velásquez GE Vallet M Varaine F Yuya-Septoh FJ Mitnick CD Guglielmetti L
Trials 2023 Nov 30; 24(1); . doi: 10.1186/s13063-023-07701-6. Epub 2023 11 30
Bedaquiline Clofazimine Delamanid Fluroquinolone-resistant Linezolid MDR-TB Multidrug-resistant Non-inferiority Pre-XDR TB RR-TB Rifampicin-resistant Stratified medicine Treatment shortening Tuberculosis

Real life condition evaluation of Inoserp PAN-AFRICA antivenom effectiveness in Cameroon.

Abstract

BACKGROUND: Snakebites is a serious public health issue but remains a neglected tropical disease. Data on antivenom effectiveness are urgently needed in Africa.

Chippaux JP Ntone R Benhammou D Madec Y Noël G Perilhou A Karl F Amta P Sanchez M Matchim L Clauteaux P Eteki L Ndifon M Boum Y Nkwescheu AS Taieb F
PLoS neglected tropical diseases 2023 Nov 08; 17(11); . doi: 10.1371/journal.pntd.0011707. Epub 2023 11 08

Effectiveness of a community-based approach for the investigation and management of children with household tuberculosis contact in Cameroon and Uganda: a cluster-randomised trial.

Abstract

BACKGROUND: Globally, the uptake of tuberculosis-preventive treatment (TPT) among children with household tuberculosis contact remains low, partly due to the necessity of bringing children to health facilities for investigations.

Maryline Bonnet Anca Vasiliu Boris K Tchounga Benjamin Cuer Katherine Fielding Bob Ssekyanzi et al.
Lancet Glob Health. doi: https://doi.org/10.1016/S2214-109X(23)00430-8 Epub 2023 10 30
Tuberculosis Cameroon Uganda

Cost-effectiveness of community-based household tuberculosis contact management for children in Cameroon and Uganda: a modelling analysis of a cluster-randomised trial.

Abstract

BACKGROUND: WHO recommends household contact management (HCM) including contact screening and tuberculosis-preventive treatment (TPT) for eligible children.

Nyashadzaishe Mafirakureva Boris K Tchounga Sushant Mukherjee Boris Tchakounte Youngui Bob Ssekyanzi Leonie Simo et al.
Lancet Glob Health; doi: https://doi.org/10.1016/S2214-109X(23)00451-5. Epub 2023 10 30
Tuberculosis Cameroon Uganda

Acceptability of decentralizing childhood tuberculosis diagnosis in low-income countries with high tuberculosis incidence: Experiences and perceptions from health care workers in Sub-Saharan Africa and South-East Asia.

Abstract

Decentralizing childhood tuberculosis services, including diagnosis, is now recommended by the WHO and could contribute to increasing tuberculosis detection in high burden countries.

Joshi B De Lima YV Massom DM Kaing S Banga MF Kamara ET Sesay S Borand L Taguebue JV Moh R Khosa C Breton G Mwanga-Amumpaire J Bonnet M Wobudeya E Marcy O Orne-Gliemann J
PLOS global public health 2023 ; 3(10); . doi: 10.1371/journal.pgph.0001525. Epub 2023 10 11