Publications

Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda.

Abstract

Visceral leishmaniasis is common in less developed countries, with an estimated 500000 new cases each year. Because of the diversity of epidemiological situations, no single diagnosis, treatment, or control will be suitable for all.

Guerin PJ Olliaro P Sundar S Boelaert M Croft SL Desjeux P Wasunna MK Bryceson AD
The Lancet. Infectious diseases 2002 Aug ; 2(8); 494-501. doi: . Epub 2002 08 29

IgM quantification in the cerebrospinal fluid of sleeping sickness patients by a latex card agglutination test.

Abstract

An increased IgM concentration in cerebrospinal fluid (CSF), occurring as a consequence of massive intrathecal IgM synthesis, is a marker of interest for diagnosis of the meningo-encephalitic stage in human African trypanosomiasis.

Lejon V Legros D Richer M Ruiz JA Jamonneau V Truc P Doua F Djé N N'Siesi FX Bisser S Magnus E Wouters I Konings J Vervoort T Sultan F Büscher P
Tropical medicine & international health : TM & IH 2002 Aug ; 7(8); 685-92. doi: . Epub 2002 09 17

In vitro susceptibility of 120 strains of Neisseria gonorrhoeae isolated in Kyrghyzstan.

Abstract

BACKGROUND: The World Health Organization has established a worldwide program for gonococcal antimicrobial surveillance, but so far no data on gonococcal susceptibility in Central Asia are available.

Dorlencourt F Boireaux C Sednaoui P Danilenko NV Legros D
Sexually transmitted diseases 2002 Jul ; 29(7); 376-8. doi: . Epub 2002 11 05

Treatment of human African trypanosomiasis--present situation and needs for research and development.

Abstract

Human African trypanosomiasis re-emerged in the 1980s. However, little progress has been made in the treatment of this disease over the past decades. The first-line treatment for second-stage cases is melarsoprol, a toxic drug in use since 1949.

Legros D Ollivier G Gastellu-Etchegorry M Paquet C Burri C Jannin J Büscher P
The Lancet. Infectious diseases 2002 Jul ; 2(7); 437-40. doi: . Epub 2002 08 06

Validity, reliability and ease of use in the field of five rapid tests for the diagnosis of Plasmodium falciparum malaria in Uganda.

Abstract

A study was conducted to measure the overall performance of several rapid diagnostic tests for Plasmodium falciparum infection, in order to select the most appropriate test to be used in the field.

Guthmann JP Ruiz A Priotto G Kiguli J Bonte L Legros D
Transactions of the Royal Society of Tropical Medicine and Hygiene ; 96(3); 254-7. doi: . Epub 2002 09 27

Interleukin (IL)-6, IL-8 and IL-10 in serum and CSF of Trypanosoma brucei gambiense sleeping sickness patients before and after treatment.

Abstract

Serum and cerebrospinal fluid (CSF) concentrations of interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-alpha and interferon-gamma were determined in 46 Trypanosoma brucei gambiense sleeping sickness patients in DR Congo, before and after treatme

Lejon V Lardon J Kenis G Pinoges L Legros D Bisser S N'Siesi X Bosmans E Büscher P
Transactions of the Royal Society of Tropical Medicine and Hygiene ; 96(3); 329-33. doi: . Epub 2002 09 27

Clinical efficacy of chloroquine or sulfadoxine-pyrimethamine in children under five from south-western Uganda with uncomplicated falciparum malaria.

Abstract

We conducted a 14-day study (during March-May 1998) to assess the efficacy of chloroquine and sulfadoxine-pyrimethamine (SP) for treating uncomplicated Plasmodium falciparum malaria in Uganda.

Legros D Johnson K Houpikian P Makanga M Kabakyenga JK Talisuna AO Taylor WR
Transactions of the Royal Society of Tropical Medicine and Hygiene ; 96(2); 199-201. doi: . Epub 2002 07 09

An outbreak of Rift Valley fever in Northeastern Kenya, 1997-98.

Abstract

In December 1997, 170 hemorrhagic fever-associated deaths were reported in Garissa District, Kenya. Laboratory testing identified evidence of acute Rift Valley fever virus (RVFV).

Woods CW Karpati AM Grein T McCarthy N Gaturuku P Muchiri E Dunster L Henderson A Khan AS Swanepoel R Bonmarin I Martin L Mann P Smoak BL Ryan M Ksiazek TG Arthur RR Ndikuyeze A Agata NN Peters CJ
Emerging infectious diseases 2002 Feb ; 8(2); 138-44. doi: 10.3201/eid0802.010023. Epub 2002 09 06