Antimalarial treatments less effective in severely malnourished children

Wednesday 24 July 2019
Malaria Lumefantrine Treatment Effectiveness Malnutrition
It calls urgently for further research into optimized dosing regimens for undernourished children.
Antimalarial treatments malnourished children
Corps éditorial

The study in a nutshell

Researchers have found that severe malnutrition is associated with lower exposure to the antimalarial drug lumefantrine in children treated with artemether-lumefantrine, the most common treatment for uncomplicated falciparum malaria. The study, which is the first to specifically address this, has been published in Clinical Pharmacology and Therapeutics. Below is the press release issued on the occasion of the publication of the article related to the study.

Related publication

Severe acute malnutrition results in lower lumefantrine exposure in children treated with artemether-lumefantrine for uncomplicated malaria.

Journal Reference: Clinical pharmacology and therapeutics 2019 Jun 01; (); Array. doi: 10.1002/cpt.1531. Epub 2019 06 01
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Related press release

Classification principale

Antimalarial treatments less effective in severely malnourished children

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Nutrional diseases

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Mid-Upper Arm Circumference (MUAC)  is simple method of identifying malnourished young children.