Culture Conversion in Patients Treated with Bedaquiline and/or Delamanid: A Prospective Multi-country Study.


Background Bedaquiline and delamanid offer the possibility of more effective and less toxic multidrug-resistant tuberculosis (MDR-TB) treatment. With this treatment, however, some patients, remain at high risk for an unfavorable treatment outcome.

Authors: Franke MF Khan P Hewison C Khan U Huerga H Seung KJ Rich ML Zarli K Samieva N Oyewusi L Nair P Mudassar M Melikyan N Lenggogeni P Lecca L Kumsa A Khan M Islam S Hussein K Docteur W Chumburidze N Berikova E Atshemyan H Atwood S Alam M Ahmed S Bastard M Mitnick CD
Journal Reference: American journal of respiratory and critical care medicine 2020 Jul 24; (); Array. doi: 10.1164/rccm.202001-0135OC. Epub 2020 07 24
extensively drug-resistant tuberculosis interim outcome multidrug-resistant tuberculosis rifampicin-resistant tuberculosis sputum conversion

Magnitude of screening for gestational diabetes mellitus in an urban setting in Tanzania; a cross-sectional analytic study.


BACKGROUND: Medical screening detects risk factors for disease or presence of disease in otherwise well persons in order to intervene early and reduce morbidity and mortality.

Authors: Mukuve A Noorani M Sendagire I Mgonja M
Journal Reference: BMC pregnancy and childbirth 2020 Jul 23; 20(1); 418. doi: 10.1186/s12884-020-03115-3. Epub 2020 07 23
Hyperglycaemia in pregnancy Screening Tanzania

Prevalence, associated factors and clinical features of congenital syphilis among newborns in Mbarara hospital, Uganda.


BACKGROUND: While congenital syphilis is a significant public health problem that can cause severe disabilities, little is known about the situation in Uganda.

Authors: Oloya S Lyczkowski D Orikiriza P Irama M Boum Y Migisha R Kiwanuka JP Mwanga-Amumpaire J
Journal Reference: BMC pregnancy and childbirth 2020 Jul 02; 20(1); 385. doi: 10.1186/s12884-020-03047-y. Epub 2020 07 02
Adverse outcome Stillbirth Syphilis; congenital syphilis

Clinical and epidemiological performance of WHO Ebola case definitions: a systematic review and meta-analysis.


BACKGROUND: Ebola virus disease case definition is a crucial surveillance tool to detect suspected cases for referral and as a screening tool for clinicians to support admission and laboratory testing decisions at Ebola health faciliti

Authors: Caleo G Theocharaki F Lokuge K Weiss HA Inamdar L Grandesso F Danis K Pedalino B Kobinger G Sprecher A Greig J Di Tanna GL
Journal Reference: The Lancet. Infectious diseases 2020 Jun 25; (); Array. doi: 10.1016/S1473-3099(20)30193-6. Epub 2020 06 25

HIV epidemic and cascade of care in 12 east African rural fishing communities: results from a population-based survey in Uganda.


BACKGROUND: In East Africa, fishing communities are considered most-at-risk populations for the acquisition of HIV.

Authors: Burgos-Soto J Ben Farhat J Alley I Ojuka P Mulogo E Kise-Sete T Bouhenia M Salumu L Mathela R Langendorf C Cohuet S Huerga H
Journal Reference: BMC public health 2020 Jun 19; 20(1); 970. doi: 10.1186/s12889-020-09121-6. Epub 2020 06 19
Africa Antiretroviral therapy Cascade of care Communities Diagnosis Epidemic Fishing HIV Viral suppression

Systematic or Test-Guided Treatment for Tuberculosis in HIV-Infected Adults.


BACKGROUND: In regions with high burdens of tuberculosis and human immunodeficiency virus (HIV), many HIV-infected adults begin antiretroviral therapy (ART) when they are already severely immunocompromised.

Authors: Blanc FX Badje AD Bonnet M Gabillard D Messou E Muzoora C Samreth S Nguyen BD Borand L Domergue A Rapoud D Natukunda N Thai S Juchet S Eholié SP Lawn SD Domoua SK Anglaret X Laureillard D
Journal Reference: The New England journal of medicine 2020 06 18; 382(25); 2397-2410. doi: 10.1056/NEJMoa1910708. Epub 2020 06 19

Humoral and cellular immune response induced by rVSVΔG-ZEBOV-GP vaccine among frontline workers during the 2013-2016 West Africa Ebola outbreak in Guinea.


BACKGROUND: As part of a Phase III trial with the Ebola vaccine rVSVΔG-ZEBOV-GP in Guinea, we invited frontline workers (FLWs) to participate in a sub-study to provide additional information on the immunogenicity of the vaccine.

Authors: Boum Y Juan-Giner A Hitchings M Soumah A Strecker T Sadjo M Cuthbertson H Hayes P Tchaton M Jemmy JP Clarck C King D Faga EM Becker S Halis B Gunnstein N Carroll M Røttingen JA Kondé MK Doumbia M Henao-Restrepo AM Kieny MP Cisse M Draguez B Grais RF
Journal Reference: Vaccine 2020 Jun 01; (); Array. doi: 10.1016/j.vaccine.2020.04.066. Epub 2020 06 01
Cellular response Ebola vaccine Frontline workers Humoral response Immunogenicity

To fast or not to fast: Lipid measurement and cardiovascular disease risk estimation in rural sub-Saharan Africa.


Background: Cardiovascular disease (CVD) morbidity and mortality are increasing in sub-Saharan Africa (sSA), highlighting the need for tools to enable CVD risk stratification in the region.

Authors: Yang IT Hemphill LC Kim JH Bibangambah P Sentongo R Kakuhire B Plutzky J Boum Y Tsai AC Okello S Siedner MJ
Journal Reference: Journal of global health 2020 Jun ; 10(1); 010407. doi: 10.7189/jogh.10.010407. Epub 2020 04 15

Prevention of child wasting: Results of a Child Health & Nutrition Research Initiative (CHNRI) prioritisation exercise.


BACKGROUND: An estimated 49.5 million children under five years of age are wasted. There is a lack of robust studies on effective interventions to prevent wasting.

Authors: Frison S Angood C Khara T Bahwere P Black RE Briend A Connell N Fenn B Isanaka S James P Kerac M Mayberry A Myatt M Dolan C
Journal Reference: PloS one 2020 ; 15(2); e0228151. doi: 10.1371/journal.pone.0228151. Epub 2020 02 12