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Relevance of more stringent discharge standards for acute malnutrition treatment: A pooled analysis of post-treatment relapse in 21 studies.

Abstract

BACKGROUND: The World Health Organization recently recommended that both Weight-for-Height Z-score (WHZ) and Mid-Upper-Arm-Circumference (MUAC) exceed Moderate Acute Malnutrition (MAM) thresholds before a child with Severe Acute Malnut

Guesdon B Rattigan SM Grellety E Bliznashka L Donnen P Bilukha O
The American journal of clinical nutrition 2026 Mar 11; . doi: 10.1016/j.ajcnut.2026.101264. Epub 2026 03 11
Anthropometry acute malnutrition case definition discharge relapse wasting

Oral rehydration for severe malnutrition in children with moderate and severe dehydration (GASTROSAM): a phase 2, open-label, superiority randomised controlled trial.

Abstract

BACKGROUND: International guidelines for treatment of children with severe acute malnutrition advise against giving standard oral rehydration solutions (ORS) for dehydration secondary to diarrhoea.

Maitland K Sainna H Connon R Ouattara SM Sunyoto T Chara A Ogundipe OF Maguina AS Hamaluba M Olupot-Olupot P Alaroker F Okiror W Aromut D Mwajombo E Oguda E Mogaka C Langendorf C Dewez JE Ciglenecki I Gibb DM Petrucci R Coldiron ME George EC
The Lancet. Child & adolescent health 2026 Mar 10; . doi: 10.1016/S2352-4642(25)00371-2. Epub 2026 03 10

Effect of COVID-19 pandemic on ART access and timely initiation in people living with HIV in 31 countries: a regression discontinuity design study.

Abstract

OBJECTIVES: The COVID-19 pandemic threatened global HIV Test and Treat Efforts.

Ben Farhat J Messou E Borse R Varela Bustillo D Madimabe M Nash D Byakwaga H Shah NS Ezechi O Pujari S Veloso VG Hobbins M Murenzi G Mkwashapi D Hogan B Choi JY Minga A Crabtree-Ramírez B Twizere C Diero L Haw J Bolton-Moore C Cortes CP Lee MP Mbewe S Brazier E Humphrey JM Althoff KN Bonnet F Barger D Jaquet A
BMJ open 2026 Mar 10; 16(3); . doi: 10.1136/bmjopen-2025-112903. Epub 2026 03 10
COVID-19 Drug Therapy HIV & AIDS

Strengthening research regulatory capacity in the East African community: a multi-country training program on emerging and complex study designs.

Abstract

BACKGROUND: The East African Community (EAC) has experienced a significant increase in volume and complexity of clinical research driven by the epidemics of emerging and re-emerging infectious diseases such as HIV, Ebola, COVID-19, and

Amperiize M Twesigye B Mutumba B Opolot H Gardais S Wandiga S Ndagije H Kidola J Mutabazi V Nyandwi R Mathew LS Twungubumwe N Castelnuovo B Arinaitwe JW Okoboi S Ainembabazi P Byakika-Kibwika P
BMC medical ethics 2026 Mar 02; . doi: 10.1186/s12910-026-01418-2. Epub 2026 03 02
Capacity building Emerging and complex study designs National research regulatory authority Research ethics committees Researchers

Multicountry genomic analysis underscores regional cholera spread in Africa.

Abstract

Cholera remains a significant public health burden in many countries in sub-Saharan Africa, though the exact mechanisms of bacterial emergence and spread remain largely undefined.

Mboowa G Matteson NL Tanui CK Kasonde M Kamwiziku GK Akanbi OA Chitio JJE Kagoli M Essomba RG Ayitewala A Ssewanyana I Ngo Bitoungui VJ Amuri AA Azman AS Babatunde OA Akenji BM Broban A Malembaka EB Ongole F Chukwu CE Ismael N Kapona O Laurindo O Mbala PK Etoundi Mballa GA Miambo ICZ Mwanyongo AA Najjuka G Mutale J Musonda K Niyonzima AM Nyenje ME Popoola M Shempela DM Sike CM Sitoe SM Wanjohi DW Welo PO Yelewa M Yennan S Ziba L Bitilinyu-Bangoh JE Chilengi R Hadja H Idris J Langa JPM Mukadi-Bamuleka D Nabadda S Debes AK Sack DA Tebeje YK Wohl S Tessema SK
Nature communications 2026 Feb 09; . doi: 10.1038/s41467-026-68642-7. Epub 2026 02 09

Estimating the effect of hepatitis C infection on multidrug-resistant tuberculosis treatment outcomes under hypothetical interventions on regimen composition and adherence.

Abstract

Hepatitis C virus (HCV) infection is associated with unfavorable multidrug- and rifampicin-resistant (MDR/RR) tuberculosis (TB) outcomes.

LaHood A Robins J Stagg HR Sauer S Ahmed S Bastard M Guglielmetti L Hewison C Huerga H Isani AK Khan P Khan U Lomtadze N Mamsa S Melikyan N Mitnick CD Rich ML Seung K Siddiqui MR Skrahina A Stambekova A Tefera GB Franke MF
American journal of epidemiology 2026 Feb 02; . doi: 10.1093/aje/kwag024. Epub 2026 02 02
Multidrug-resistant tuberculosis hepatitis C losses-to-follow-up rifampicin-resistant tuberculosis treatment adherence

Burden of malaria among children aged 5-10 years in the Sahelian area: do we need to adapt seasonal malaria chemoprophylaxis?

Abstract

BACKGROUND: Despite its Sahelian context, Niger is one of the sub-Saharan countries reporting the highest number of malaria cases.

Djedanem M Yacoubou MAY Zakari A Issa I Yahaya M Zaneidou M Mody I Onana DB Testa J Jambou R
BMC infectious diseases 2026 Jan 30; . doi: 10.1186/s12879-025-12286-3. Epub 2026 01 30
Chemoprevention Children Malaria Niger Sahel Seasonal transmission

Low-dose yellow fever vaccination in infants: a randomised, double-blind, non-inferiority trial.

Abstract

BACKGROUND: WHO recommends fractional dose vaccination to address yellow fever vaccine shortages during outbreaks.

Kimathi D Juan-Giner A Bob NS Orindi B Namulwana ML Diatta A Cheruiyot S Fall G Dia M Hamaluba MM Nyehangane D Karanja HK Gitonga JN Mugo D Omuoyo DO Hussein M Oloo E Kamau N Wafula J Bendera J Silvester N Mwavita J Joshua M Thuranira JM Agababyona C Ngetsa C Aisha N Moki F Buluku T Munene M Mwanga-Amumpaire J Lutwama J Kayiwa J Kamaara E Barrett AD Kaleebu P Bejon P Sall AA Grais RF Warimwe GM
Lancet (London, England) 2026 Jan 13; . doi: 10.1016/S0140-6736(25)02069-0. Epub 2026 01 13

Community and hospital-acquired invasive bacterial infections in hospitalised patients with advanced HIV disease: a prospective study in Kinshasa, DRC.

Abstract

BACKGROUND: Advanced HIV patients face high mortality, often from invasive bacterial infections (IBI), while rising antimicrobial resistance (AMR) threatens treatment.

Langendorf C Bossard C Nackers F Comelli A Berghmans M Molay G Gomez FG Dicko A Bangwen E Kalwangila T Mangana F Kilundu A Beni RN Mboyo A Burton R Lumowo GM Isaakidis P
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2026 Jan 10; . doi: 10.1016/j.ijid.2026.108383. Epub 2026 01 10
Invasive bacterial infection advanced HIV disease antimicrobial resistance low-resource settings

Health-economic impacts of age-targeted and sex-targeted Lassa fever vaccination in endemic regions of Nigeria, Guinea, Liberia, and Sierra Leone: a modelling study.

Abstract

BACKGROUND: Lassa fever is an emerging zoonotic disease endemic to west Africa.

Smith DRM Antony Oliver MC Holohan KM Street HR Torkelson AA Asogun D Ayodeji OO Azuogu BN Camacho A Fischer WA Grant DS Jan K Okogbenin SA Sibley J Wohl DA Hollingsworth TD Pouwels KB
The Lancet. Global health 2026 Feb ; 14(2); . doi: 10.1016/S2214-109X(25)00450-4. Epub 2026 01 10