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Evaluating newly approved drugs in combination regimens for multidrug-resistant tuberculosis with fluoroquinolone resistance (endTB-Q): study protocol for a multi-country randomized controlled trial.

Abstract

BACKGROUND: Treatment for fluoroquinolone-resistant multidrug-resistant/rifampicin-resistant tuberculosis (pre-XDR TB) often lasts longer than treatment for less resistant strains, yields worse efficacy results, and causes substantial

Patil SB Tamirat M Khazhidinov K Ardizzoni E Atger M Austin A Baudin E Bekhit M Bektasov S Berikova E Bonnet M Caboclo R Chaudhry M Chavan V Cloez S Coit J Coutisson S Dakenova Z De Jong BC Delifer C Demaisons S Do JM Dos Santos Tozzi D Ducher V Ferlazzo G Gouillou M Khan U Kunda M Lachenal N LaHood AN Lecca L Mazmanian M McIlleron H Moreau M Moschioni M Nahid P Osso E Oyewusi L Panda S Pâquet A Thuong Huu P Pichon L Rich ML Rupasinghe P Salahuddin N Sanchez Garavito E Seung KJ Velásquez GE Vallet M Varaine F Yuya-Septoh FJ Mitnick CD Guglielmetti L
Trials 2023 Nov 30; 24(1); . doi: 10.1186/s13063-023-07701-6. Epub 2023 11 30
Bedaquiline Clofazimine Delamanid Fluroquinolone-resistant Linezolid MDR-TB Multidrug-resistant Non-inferiority Pre-XDR TB RR-TB Rifampicin-resistant Stratified medicine Treatment shortening Tuberculosis

Real life condition evaluation of Inoserp PAN-AFRICA antivenom effectiveness in Cameroon.

Abstract

BACKGROUND: Snakebites is a serious public health issue but remains a neglected tropical disease. Data on antivenom effectiveness are urgently needed in Africa.

Chippaux JP Ntone R Benhammou D Madec Y Noël G Perilhou A Karl F Amta P Sanchez M Matchim L Clauteaux P Eteki L Ndifon M Boum Y Nkwescheu AS Taieb F
PLoS neglected tropical diseases 2023 Nov 08; 17(11); . doi: 10.1371/journal.pntd.0011707. Epub 2023 11 08

Effectiveness of a community-based approach for the investigation and management of children with household tuberculosis contact in Cameroon and Uganda: a cluster-randomised trial.

Abstract

BACKGROUND: Globally, the uptake of tuberculosis-preventive treatment (TPT) among children with household tuberculosis contact remains low, partly due to the necessity of bringing children to health facilities for investigations.

Maryline Bonnet Anca Vasiliu Boris K Tchounga Benjamin Cuer Katherine Fielding Bob Ssekyanzi et al.
Lancet Glob Health. doi: https://doi.org/10.1016/S2214-109X(23)00430-8 Epub 2023 10 30
Tuberculosis Cameroon Uganda

Cost-effectiveness of community-based household tuberculosis contact management for children in Cameroon and Uganda: a modelling analysis of a cluster-randomised trial.

Abstract

BACKGROUND: WHO recommends household contact management (HCM) including contact screening and tuberculosis-preventive treatment (TPT) for eligible children.

Nyashadzaishe Mafirakureva Boris K Tchounga Sushant Mukherjee Boris Tchakounte Youngui Bob Ssekyanzi Leonie Simo et al.
Lancet Glob Health; doi: https://doi.org/10.1016/S2214-109X(23)00451-5. Epub 2023 10 30
Tuberculosis Cameroon Uganda

Acceptability of decentralizing childhood tuberculosis diagnosis in low-income countries with high tuberculosis incidence: Experiences and perceptions from health care workers in Sub-Saharan Africa and South-East Asia.

Abstract

Decentralizing childhood tuberculosis services, including diagnosis, is now recommended by the WHO and could contribute to increasing tuberculosis detection in high burden countries.

Joshi B De Lima YV Massom DM Kaing S Banga MF Kamara ET Sesay S Borand L Taguebue JV Moh R Khosa C Breton G Mwanga-Amumpaire J Bonnet M Wobudeya E Marcy O Orne-Gliemann J
PLOS global public health 2023 ; 3(10); . doi: 10.1371/journal.pgph.0001525. Epub 2023 10 11

Abacavir drug exposures in African children under 14 kg using paediatric solid fixed dose combinations according to World Health Organization weight bands.

Abstract

BACKGROUND: The pharmacokinetics of abacavir (ABC) in African children living with HIV (CLHIV) weighing

Chupradit S Wamalwa DC Maleche-Obimbo E Kekitiinwa AR Mwanga-Amumpaire J Bukusi EA Nyandiko WM Mbuthia JK Swanson A Cressey TR Punyawudho B Musiime V
Journal of the Pediatric Infectious Diseases Society 2023 Oct 05; . doi: 10.1093/jpids/piad082. Epub 2023 10 05
Abacavir African children Dose optimization NONMEM Population pharmacokinetics

Nationwide retrospective mortality and seroprevalence of SARS-CoV-2 antibodies in Cameroon

Abstract

BACKGROUND: Although the first year of the COVID-19 pandemic in Africa did not produce the expected catastrophe, the true impact of COVID-19 in the Cameroonian population was unclear.

J. Eyong K.N. Fai B. Nikolay E. Gignoux R. Nsaibirni D. Buri et al.
Scientific African 22 (2023) e01925; doi.org/10.1016/j.sciaf.2023.e01925
Mortality Seroprevalence SARS-CoV-2 Cameroon

Estimating post-treatment recurrence after multidrug-resistant tuberculosis treatment among patients with and without HIV: the impact of assumptions about death and missing follow-up.

Abstract

BACKGROUND: Quantification of recurrence risk following successful treatment is crucial to evaluating regimens for multidrug- or rifampicin-resistant (MDR/RR) tuberculosis (TB).

Sauer SM Mitnick CD Khan U Hewison C Bastard M Holtzman D Law S Khan M Padayachee S Ahmed S Isani AK Krisnanda A Vilbrun SC Bektasov S Kumsa A Docteur W Tintaya K McNicol M Atshemyan H Voynilo T Thwe TT Seung K Rich M Huerga H Khan P Franke M
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2023 Sep 29; . doi: 10.1093/cid/ciad589. Epub 2023 09 29
MDR-TB competing events inverse-probability weighting missing follow-up post-treatment recurrence

Time to treatment initiation and HIV viral suppression in people diagnosed with HIV-1 during COVID-19 pandemic in ex-Aquitaine, France (ANRS CO3 AQUIVIH-NA Cohort-QuAliCOV Study).

Abstract

OBJECTIVES: The Covid-19 pandemic's impact on initiation and effectiveness of antiretroviral therapy (ART) in people diagnosed with HIV remains unclear.

Ben Farhat J Hessamfar M Farbos S Desclaux A Dumondin G Ferrand H Greib C Castan B Rispal P Duffau P Leleux O Perrier A Wittkop L Bonnet F Barger D
Journal of acquired immune deficiency syndromes (1999) 2023 Sep 28; . doi: 10.1097/QAI.0000000000003310. Epub 2023 09 28