Selection bias in multidrug-resistant tuberculosis cohort studies assessing sputum culture conversion.


BACKGROUND: Conversion of sputum culture from positive to negative for M. tuberculosis is a key indicator of treatment response. An initial positive culture is a pre-requisite to observe conversion.

Rodriguez CA Lodi S Horsburgh CR Bastard M Hewison C Huerga H Khan M Khan PY Khan U Oyewusi L Padayachee S Mitnick CD Franke MF
PloS one 2022 ; 17(11); . doi: 10.1371/journal.pone.0276457. Epub 2022 11 10

Differential symptomatology of possible and confirmed Ebola virus disease infection in the Democratic Republic of the Congo: a retrospective cohort study.


BACKGROUND: In its earliest phases, Ebola virus disease's rapid-onset, high fever, and gastrointestinal symptoms are largely indistinguishable from other infectious illnesses.

Nsio J Ardiet DL Coulborn RM Grellety E Albela M Grandesso F Kitenge R Ngwanga DL Matady B Manangama G Mossoko M Ngwama JK Mbala P Luquero F Porten K Ahuka-Mundeke S
The Lancet. Infectious diseases 2022 Nov 09; . doi: 10.1016/S1473-3099(22)00584-9. Epub 2022 11 09

Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial.


BACKGROUND: Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa.

Maitre T Bonnet M Calmy A Raberahona M Rakotoarivelo RA Rakotosamimanana N Ambrosioni J Miró JM Debeaudrap P Muzoora C Davis A Meintjes G Wasserman S Wilkinson R Eholié S Nogbou FE Calvo-Cortes MC Chazallon C Machault V Anglaret X Bonnet F
Trials 2022 Nov 08; 23(1); . doi: 10.1186/s13063-022-06772-1. Epub 2022 11 08
Aspirin HIV, High-dose rifampicin Linezolid Randomized controlled trial Tuberculous meningitis
Hodson DZ Mbarga Etoundi Y Mbatou Nghokeng N Mohamadou Poulibe R Magne Djoko S Goodwin J Cheteug Nguesta G Nganso T Armstrong JN Andrews JJ Zhang E Wade M Eboumbou Moukoko CE Boum Y Parikh S
Malaria journal 2022 Oct 22; 21(1); . doi: 10.1186/s12936-022-04315-2. Epub 2022 10 22
Anaemia Cameroon Douala Febrile illness Malaria Plasmodium falciparum Urban

Immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine (ERVEBO®) in African clinical trial participants by age, sex, and baseline GP-ELISA titer: A post hoc analysis of three Phase 2/3 trials.


BACKGROUND: ERVEBO®, a live recombinant vesicular stomatitis virus (VSV) vaccine containing the Zaire ebolavirus glycoprotein (GP) in place of the VSV GP (rVSVΔG-ZEBOV-GP), was advanced through clinical development by Merck & Co.,

Simon JK Kennedy SB Mahon BE Dubey SA Grant-Klein RJ Liu K Hartzel J Coller BG Welebob C Hanson ME Grais RF
Vaccine 2022 Oct 05; . doi: 10.1016/j.vaccine.2022.09.037. Epub 2022 10 05
Ebola Immunogenicity Vaccine

Impact and cost-effectiveness of rotavirus vaccination in Niger: a modelling study evaluating alternative rotavirus vaccines.


OBJECTIVES: To evaluate the cost-effectiveness of alternative rotavirus vaccines in Niger, using UNIVAC, a proportionate outcomes model.

Debellut F Tang K Clark A Pecenka C Assao B Guindo O Grais RF Isanaka S
BMJ open 2022 Oct 05; 12(10); . doi: 10.1136/bmjopen-2022-061673. Epub 2022 10 05
Health economics Health policy Paediatric infectious disease & immunisation Public health

TB screening, prevention and treatment cascade in a Malawi prison.


Incarcerated individuals, especially in high HIV and TB burden settings, are at increased risk of latent TB infection and/or TB disease. We implemented a comprehensive HIV-TB intervention in a Malawi prison and studied its feasibility.

Mangochi P Bossard C Catacutan C Van Laeken D Kwitonda C Ortuno R Chiwaula L Meis M Abura A Furin J Mpunga J Goemare E Ellman T Garone D Ferlazzo G Isaakidis P
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2022 Oct 01; 26(10); . doi: 10.5588/ijtld.22.0115. Epub 2022 09 28

Anthropometric deficits and the associated risk of death by age and sex in children aged 6-59 months: A meta-analysis.


Risk of death from undernutrition is thought to be higher in younger than in older children, but evidence is mixed. Research also demonstrates sex differences whereby boys have a higher prevalence of undernutrition than girls.

Thurstans S Wrottesley SV Fenn B Khara T Bahwere P Berkley JA Black RE Boyd E Garenne M Isanaka S Lelijveld N McDonald CM Mertens A Mwangome M O'Brien KS Stobaugh H Taneja S West KP Guerrero S Kerac M Briend A Myatt M
Maternal & child nutrition 2022 Sep 27; . doi: 10.1111/mcn.13431. Epub 2022 09 27
age mortality sex stunting underweight wasting