Estimation of the correlates of protection of the rVSVΔG-ZEBOV-GP Zaire ebolavirus vaccine: a post-hoc analysis of data from phase 2/3 clinical trials.


BACKGROUND: Establishment of immune correlates of protection can provide a measurable criterion for assessing protection against infection or disease.

Authors: Rebecca F Grais Stephen B Kennedy Barbara E Mahon Sheri A Dubey ebecca J Grant-Klein R Ken Liu Jonathan Hartzel Beth-Ann Coller Carolee Welebob Mary E Hanson Jakub K Simon
Journal Reference: Lancet Microbe 2021;2: e70–78;
Vaccination Ebola Clinical trial

Comparison of capillary versus venous blood for the diagnosis of Plasmodium falciparum malaria using rapid diagnostic tests.


We enrolled 250 febrile children in western Uganda to compare the results of malaria rapid diagnostic tests when using capillary versus venous blood. Participants were tested with four different RDT types.

Authors: Gorret AM Muhindo R Baguma E Ntaro M Mulogo EM Deutsch-Feldman M Juliano JJ Nyehangane D Boyce RM
Journal Reference: The Journal of infectious diseases 2021 Jan 27; (); Array. doi: 10.1093/infdis/jiab032. Epub 2021 01 27
Diagnostic Test Malaria Plasmodium

Immunogenicity and safety of fractional doses of yellow fever vaccines: a randomised, double-blind, non-inferiority trial.


BACKGROUND: Stocks of yellow fever vaccine are insufficient to cover exceptional demands for outbreak response. Fractional dosing has shown efficacy, but evidence is limited to the 17DD substrain vaccine.

Authors: Juan-Giner A Kimathi D Grantz KH Hamaluba M Kazooba P Njuguna P Fall G Dia M Bob NS Monath TP Barrett AD Hombach J Mulogo EM Ampeire I Karanja HK Nyehangane D Mwanga-Amumpaire J Cummings DAT Bejon P Warimwe GM Grais RF
Journal Reference: Lancet (London, England) 2021 Jan 09; 397(10269); 119-127. doi: 10.1016/S0140-6736(20)32520-4. Epub 2021 01 10

Outcomes of AIDS-associated Kaposi sarcoma in Mozambique after treatment with pegylated liposomal doxorubicin.


BACKGROUND: Kaposi's sarcoma (KS) is a common HIV-associated malignancy frequently associated with poor outcomes. It is the most frequently diagnosed cancer in major cities of Mozambique.

Authors: Coldiron ME Gutierrez Zamudio AG Manuel R Luciano G Rusch B Ciglenecki I Telnov A Grais RF Trellu LT Molfino L
Journal Reference: Infectious agents and cancer 2021 Jan 07; 16(1); 2. doi: 10.1186/s13027-020-00341-4. Epub 2021 01 07
AIDS-related opportunistic infections Acquired immunodeficiency syndrome Doxorubicin Kaposi sarcoma Mozambique

Smartphone-Based Ophthalmic Imaging Compared to Spectral Domain Optical Coherence Tomography Assessment of Vertical Cup-to-Disc Ratio among Adults in Southwestern Uganda.


PRCIS: Using optical coherence tomography measurements as a reference standard for vertical cup-to-disc ratio (vCDR), a smartphone-based ophthalmic camera has a sensitivity of 67.7% and specificity of 96.7% to detect a vCDR greater tha

Authors: Idriss BR Tran TM Atwine D Chang RT Myung D Onyango J
Journal Reference: Journal of glaucoma 2020 Dec 29; Publish Ahead of Print(); Array. doi: 10.1097/IJG.0000000000001779. Epub 2020 12 29

Feasibility of satellite image and GIS sampling for population representative surveys: a case study from rural Guatemala.


BACKGROUND: Population-representative household survey methods require up-to-date sampling frames and sample designs that minimize time and cost of fieldwork especially in low- and middle-income countries.

Authors: Miller AC Rohloff P Blake A Dhaenens E Shaw L Tuiz E Grandesso F Mendoza Montano C Thomson DR
Journal Reference: International journal of health geographics 2020 Dec 05; 19(1); 56. doi: 10.1186/s12942-020-00250-0. Epub 2020 12 05
Guatemala Population-representative study Sample selection Sampling frame Simple random sample

Successive epidemic waves of cholera in South Sudan between 2014 and 2017: a descriptive epidemiological study.


BACKGROUND: Between 2014 and 2017, successive cholera epidemics occurred in South Sudan within the context of civil war, population displacement, flooding, and drought.

Authors: Jones FK Wamala JF Rumunu J Mawien PN Kol MT Wohl S Deng L Pezzoli L Omar LH Lessler J Quilici ML Luquero FJ Azman AS
Journal Reference: The Lancet. Planetary health 2020 Dec ; 4(12); e577-e587. doi: 10.1016/S2542-5196(20)30255-2. Epub 2020 12 24

A telephone based assessment of the health situation in the far north region of Cameroon.


BACKGROUND: In 2017, Field access was considerably limited in the Far North region of Cameroon due to the conflict.

Authors: Gignoux EMH Donfack Sontsa OT Mudasiru A Eyong J Ntone R Tamakloe Koku M Adji DM Etoundi A Boum Y Jamet C Cabrol JC Porten K
Journal Reference: Conflict and health 2020 Nov 30; 14(1); 82. doi: 10.1186/s13031-020-00327-4. Epub 2020 11 30
Conflict Healthcare Mortality Telephone

Evaluating Ten Commercially-Available SARS-CoV-2 Rapid Serological Tests Using the STARD (Standards for Reporting of Diagnostic Accuracy Studies) Method.


Numerous SARS-CoV-2 rapid serological tests have been developed, but their accuracy has usually been assessed using very few samples, and rigorous comparisons between these tests are scarce.

Authors: Dortet L Ronat JB Vauloup-Fellous C Langendorf C Mendels DA Emeraud C Oueslati S Girlich D Chauvin A Afdjei A Bernabeu S Le Pape S Kallala R Rochard A Verstuyft C Fortineau N Roque-Afonso AM Naas T
Journal Reference: Journal of clinical microbiology 2020 Nov 25; (); Array. doi: 10.1128/JCM.02342-20. Epub 2020 11 25