Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.

Auteurs: Stucki D Brites D Jeljeli L Coscolla M Liu Q Trauner A Fenner L Rutaihwa L Borrell S Luo T Gao Q Kato-Maeda M Ballif M Egger M Macedo R Mardassi H Moreno M Tudo Vilanova G Fyfe J Globan M Thomas J Jamieson F Guthrie JL Asante-Poku A Yeboah-Manu D Wampande E Ssengooba W Joloba M Henry Boom W Basu I Bower J Saraiva M Vaconcellos SEG Suffys P Koch A Wilkinson R Gail-Bekker L Malla B Ley SD Beck HP de Jong BC Toit K Sanchez-Padilla E Bonnet M Gil-Brusola A Frank M Penlap Beng VN Eisenach K Alani I Wangui Ndung'u P Revathi G Gehre F Akter S Ntoumi F Stewart-Isherwood L Ntinginya NE Rachow A Hoelscher M Cirillo DM Skenders G Hoffner S Bakonyte D Stakenas P Diel R Crudu V Moldovan O Al-Hajoj S Otero L Barletta F Jane Carter E Diero L Supply P Comas I Niemann S Gagneux S
Référence de l'article: Nature genetics 2016 12 ; 48(12); 1535-1543. doi: 10.1038/ng.3704. Epub 2016 10 31
eng

Abstract

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.