Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.

Auteurs: Stucki D Brites D Jeljeli L Coscolla M Liu Q Trauner A Fenner L Rutaihwa L Borrell S Luo T Gao Q Kato-Maeda M Ballif M Egger M Macedo R Mardassi H Moreno M Tudo Vilanova G Fyfe J Globan M Thomas J Jamieson F Guthrie JL Asante-Poku A Yeboah-Manu D Wampande E Ssengooba W Joloba M Henry Boom W Basu I Bower J Saraiva M Vaconcellos SEG Suffys P Koch A Wilkinson R Gail-Bekker L Malla B Ley SD Beck HP de Jong BC Toit K Sanchez-Padilla E Bonnet M Gil-Brusola A Frank M Penlap Beng VN Eisenach K Alani I Wangui Ndung'u P Revathi G Gehre F Akter S Ntoumi F Stewart-Isherwood L Ntinginya NE Rachow A Hoelscher M Cirillo DM Skenders G Hoffner S Bakonyte D Stakenas P Diel R Crudu V Moldovan O Al-Hajoj S Otero L Barletta F Jane Carter E Diero L Supply P Comas I Niemann S Gagneux S
Référence de l'article: Nature genetics 2016 12 ; 48(12); 1535-1543. doi: 10.1038/ng.3704. Epub 2016 10 31


Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.